Protein Alignment CG32054 and SLC2A3

DIOPT Version :10

• Sequence 1: NP_729588.1
• Gene: CG32054 / 326185
• FlyBaseID: FBgn0052054
• Length: 563
• Species: Drosophila melanogaster
• Sequence 2: NP_008862.1
• Gene: SLC2A3 / 6515
• HGNCID: 11007
• Length: 496
• Species: Homo sapiens
• Alignment Length: 529
• Identity: 107/529 - (20%)
• Similarity: 181/529 - (34%)
• Gaps: 166/529 - (31%)

  Fly    98 NPPQQTIT--VNNSWYSRNQKNKPQSNAVGAAGLIFVSGGMNIAWSIGFRGVLHYKTTEHNFAAW 160
            |.|::.|.  :|.:...:.  |.|.|..:           :...||:             :.|.:
Human    32 NAPEKIIKEFINKTLTDKG--NAPPSEVL-----------LTSLWSL-------------SVAIF 70

  Fly   161 FIGGIIGAVISWFLINNVAKKYVLIFSSFLVMIGGILTTSTK--NSGDATLAASYLDGIANGLV- 222
            .:||:||:......:|...::..::..:.|.:.||......|  .|.:..:....:.|:..||.
Human    71 SVGGMIGSFSVGLFVNRFGRRNSMLIVNLLAVTGGCFMGLCKVAKSVEMLILGRLVIGLFCGLCT 135

  Fly   223 -FAPFMALAGEVSVSYMRGMVSASIEQMCFG----LGIFLQIIYTSTWNSTAYPSYNSFSAENMK 282
             |.|.  ..||:|.:.:||         .||    |||.:.|:....           |..|.:.
Human   136 GFVPM--YIGEISPTALRG---------AFGTLNQLGIVVGILVAQI-----------FGLEFIL 178

  Fly   283 G---VLSIIYGF--LALIIGSL---LCIESPVIMLAKNNDEQGAIDALRRLQRPYTLTNETFEQL 339
            |   :..::.||  |..|:.|.   .|.|||..:|....:|:.|...|:||.....::.: .:::
Human   179 GSEELWPLLLGFTILPAILQSAALPFCPESPRFLLINRKEEENAKQILQRLWGTQDVSQD-IQEM 242

  Fly   340 AEHKKYLAQNKE---LSMGQSIGQALPTFIRLVF-----LRGLNAMSISKFVMIGFVYS--FASP 394
            .:....::|.|:   |.:.:......|..|.:|.     |.|:||:         |.||  ....
Human   243 KDESARMSQEKQVTVLELFRVSSYRQPIIISIVLQLSQQLSGINAV---------FYYSTGIFKD 298

  Fly   395 YGYVSPSVGWFIGFGVCRWMGNFIATFCMESCGRKKPTLLGL---IVCSV--------------M 442
            .|...| :...||.||...:...::.|.:|..||:...::||   ..||.              |
Human   299 AGVQEP-IYATIGAGVVNTIFTVVSLFLVERAGRRTLHMIGLGGMAFCSTLMTVSLLLKDNYNGM 362

  Fly   443 SFVVAGQFNIFT----YNTGNNIMLLVFELFA----------------------GIAFTATSPYL 481
            |||..|...:|.    ...|.....:|.|||:                      |:.|.:.:.||
Human   363 SFVCIGAILVFVAFFEIGPGPIPWFIVAELFSQGPRPAAMAVAGCSNWTSNFLVGLLFPSAAHYL 427

  Fly   482 SEAFPLEVKQHFISFTFIGEMLVFLVLTLIRWSSSGGANYFYVMGGLYLFGFFFGLVCLPETRRT 546
            ..         ::...|.|.::.||..|..:                           :||||..
Human   428 GA---------YVFIIFTGFLITFLAFTFFK---------------------------VPETRGR 456

  Fly   547 TLREAQDKF 555
            |..:....|
Human   457 TFEDITRAF 465

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG32054	NP_729588.1	Pro-rich	<7..102	CDD:464580	2/3 (67%)
		MFS	157..555	CDD:475125	97/466 (21%)
SLC2A3	NP_008862.1	MFS_GLUT_Class1	12..456	CDD:340989	105/518 (20%)
		Important for selectivity against fructose. /evidence=ECO:0000269|PubMed:26176916	277..279		0/1 (0%)