DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32052 and Smpdl3a

DIOPT Version :9

Sequence 1:	NP_001303410.1	Gene:	CG32052 / 326184	FlyBaseID:	FBgn0044328	Length:	509	Species:	Drosophila melanogaster
Sequence 2:	NP_065586.3	Gene:	Smpdl3a / 57319	MGIID:	1931437	Length:	445	Species:	Mus musculus

Alignment Length:	477	Identity:	151/477 - (31%)
Similarity:	237/477 - (49%)	Gaps:	67/477 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 ISWL---GFLLAYSGLPGAQA----RIGYFWHISDLHLDTLYSTQGDIYRSCWELARSVSGSNAN 63
            ::||   |.     |:|.|.|    .:|.|||::|||||..|....|..:.|    .|..|:||:
Mouse    13 VAWLCGPGL-----GVPLAPADRAPAVGQFWHVTDLHLDPTYHITDDRTKVC----ASSKGANAS 68

  Fly    64 SAASEPPGPFGHYNCDSPWRLIESAVKTMKAKQGDNVEFVLWTGDALSHSAQP-LSEQKQHEILR 127
            :     |||||...||||::||.||...:| ..|....|::||||:..|...| ||.....:::.
Mouse    69 N-----PGPFGDVLCDSPYQLILSAFDFIK-NSGQEASFMIWTGDSPPHVPVPELSTGTVIKVIT 127

  Fly   128 NITELLGRSFSSQFIFPVLGHED----------GSGSYRRLGELWRHWLPSEALVTFDQGGYYSI 182
            |:|..:...|.:..:||.||:.|          .|..|..:.:||:.||..||:.|..:||:||
Mouse   128 NMTMTVQNLFPNLQVFPALGNHDYWPQDQLPIVTSKVYSAVADLWKPWLGEEAISTLKKGGFYS- 191

  Fly   183 EQTKSR--LRIVALNTNFMRLDPDPDPRASLSLRWPAEYFAEPKASVSSISAEDELLAEQQWLWL 245
            ::..|.  |||::||||.                    |:.   .::.:::..|   ...|:.||
Mouse   192 QKVASNPGLRIISLNTNL--------------------YYG---PNIMTLNKTD---PANQFEWL 230

  Fly   246 EEVLTKSKEKQETVYIVGHMPPGVDERHLGTQHNQLTFTERNNQRYLDMVRRFAPVIQGQFFGHL 310
            |..|..|...:|.|||:.|:|.|    :|....:.....:..|::.||:.||::.||.|||:||.
Mouse   231 ENTLNSSLWNKEKVYIIAHVPVG----YLPYATDTPAIRQYYNEKLLDIFRRYSSVIAGQFYGHT 291

  Fly   311 HSDTFRLIYDAKGNPISWLMIAPSIVPRKAGI-GSSNNPALRLYKFDTGSGQVLDYTQFWLDLPL 374
            |.|:..::.|..|||::.:.:||::.|.|..: ..:|||.:||:::..|...:||..|::|:|..
Mouse   292 HRDSLMVLSDKNGNPLNSVFVAPAVTPVKGVLQKETNNPGVRLFQYKPGDYTLLDMVQYYLNLTE 356

  Fly   375 ANRANEPTWQPEYNLTHYYALPEISAVALHNFAERFTGTDLSWFTRYHRANAVRYHSGSACPGLC 439
            ||...|..|..||.||..|::.::...:|:...::|...|...|.:|:....|.|.|.:.|...|
Mouse   357 ANLKGESNWTLEYVLTQAYSVADLQPKSLYALVQQFATKDSKQFLKYYHYYFVSYDSSATCDQHC 421

  Fly   440 MLNHYCAITRLDYDEFRICLEK 461
            .....|||..||...:..||::
Mouse   422 KTLQVCAIMNLDSMSYDDCLKQ 443

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32052	NP_001303410.1	MPP_ASMase	28..351	CDD:277321	109/336 (32%)
Smpdl3a	NP_065586.3	MPP_ASMase	37..333	CDD:277321	109/336 (32%)
Smpdl3a	NP_065586.3	Metallophos	73..294	CDD:278574	79/252 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	144	1.000	Domainoid score	I4583
eggNOG	1	0.900	-	-		E1_KOG3770
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	239	1.000	Inparanoid score	I3347
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53732
OrthoDB	1	1.010	-	-		D369165at33208
OrthoFinder	1	1.000	-	-		FOG0000551
OrthoInspector	1	1.000	-	-		otm44214
orthoMCL	1	0.900	-	-		OOG6_102108
Panther	1	1.100	-	-	O	PTHR10340
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R975
SonicParanoid	1	1.000	-	-		X2142
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.870