Protein Alignment CG32052 and SMPDL3B

DIOPT Version :10

• Sequence 1: NP_729555.4
• Gene: CG32052 / 326184
• FlyBaseID: FBgn0044328
• Length: 509
• Species: Drosophila melanogaster
• Sequence 2: XP_011539561.1
• Gene: SMPDL3B / 27293
• HGNCID: 21416
• Length: 485
• Species: Homo sapiens
• Alignment Length: 531
• Identity: 174/531 - (32%)
• Similarity: 262/531 - (49%)
• Gaps: 105/531 - (19%)

  Fly     6 ISWLGFLLAYSG-----------------------------LPGAQARIGYFWHISDLHLDTLYS 41
            ::||.||..:.|                             .||.:|  |.||||:|||||..|.
Human     4 LAWLIFLANWGGARAEPEEAQGPCAQEKGKGPPPTSILASLAPGLEA--GKFWHIADLHLDPDYK 66

  Fly    42 TQGDIYRSCWELARSVSGSNANSAASEP---PGPFGHYNCDSPWRLIESAVKTMKAKQGDNVEFV 103
            ...|.::.|            .||.|:|   .||:|.|.|||||.||.|::..||..:.: .:|:
Human    67 VSKDPFQVC------------PSAGSQPVPDAGPWGDYLCDSPWALINSSIYAMKEIEPE-PDFI 118

  Fly   104 LWTGDALSH-SAQPLSEQKQHEILRNITELLGRSFSSQFIFPVLGHED---------GSGS-YRR 157
            |||||...| ..:.|.|....||:..:|:|:...|....::..||:.|         ||.: |.:
Human   119 LWTGDDTPHVPDEKLGEAAVLEIVERLTKLIREVFPDTKVYAALGNHDFHPKNQFPAGSNNIYNQ 183

  Fly   158 LGELWRHWLPSEALVTFDQGGYY--SIEQTKSRLRIVALNTNFMRLDPDPDPRASLSLRWPAEYF 220
            :.|||:.||.:|::..|.:|.:|  .:.......|||.||||.                    |:
Human   184 IAELWKPWLSNESIALFKKGAFYCEKLPGPSGAGRIVVLNTNL--------------------YY 228

  Fly   221 AEPKASVSSISAEDELLAE--QQWLWLEEVLTKSKEKQETVYIVGHMPPGVDERHLGTQHNQLTF 283
            ..     ::::|:   :|:  ||:.|||:|||.:.:..:.||||||:|||..|:   || |:..|
Human   229 TS-----NALTAD---MADPGQQFQWLEDVLTDASKAGDMVYIVGHVPPGFFEK---TQ-NKAWF 281

  Fly   284 TERNNQRYLDMVRRFAPVIQGQFFGHLHSDTFRLIYDAKGNPISWLMIAPSIVPRKAG----IGS 344
            .|..|::||.:||:...||.||||||.|:|:||::||..|.|||.:.|.|.:.|.|..    :..
Human   282 REGFNEKYLKVVRKHHRVIAGQFFGHHHTDSFRMLYDDAGVPISAMFITPGVTPWKTTLPGVVNG 346

  Fly   345 SNNPALRLYKFDTGSGQVLDYTQFWLDLPLANRANEPTWQPEYNLTHYYALPEISAVALHNFAER 409
            :||||:|::::|..:..:.|...::::|..||....|.|:.||.||..|.:|:.||.::|...:|
Human   347 ANNPAIRVFEYDRATLSLKDMVTYFMNLSQANAQGTPRWELEYQLTEAYGVPDASAHSMHTVLDR 411

  Fly   410 FTGTDLSWFTRYHRANAVRYHSGSACPGLCMLNHYCAITRLDYDEFRICLEKEQLALQGRAPAAL 474
            ..| |.|...||:..|:|.|.:| .|...|.:.|.||:.::|.|.:..|     |...|..|...
Human   412 IAG-DQSTLQRYYVYNSVSYSAG-VCDEACSMQHVCAMRQVDIDAYTTC-----LYASGTTPVPQ 469

  Fly   475 MPTSWSWLLGV 485
            :|.....|||:
Human   470 LPLLLMALLGL 480

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG32052	NP_729555.4	MPP_ASMase	28..351	CDD:277321	123/344 (36%)
		ASMase_C	324..462	CDD:466022	46/141 (33%)
SMPDL3B	XP_011539561.1	MPP_ASMase	53..353	CDD:277321	123/344 (36%)
		ASMase_C	323..459	CDD:466022	46/142 (32%)