DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31988 and TGFB1I1

DIOPT Version :9

Sequence 1:	NP_001286122.1	Gene:	CG31988 / 326182	FlyBaseID:	FBgn0051988	Length:	178	Species:	Drosophila melanogaster
Sequence 2:	NP_001035919.1	Gene:	TGFB1I1 / 7041	HGNCID:	11767	Length:	461	Species:	Homo sapiens

Alignment Length:	168	Identity:	65/168 - (38%)
Similarity:	104/168 - (61%)	Gaps:	1/168 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 VCHKCQEAITKRMITALGKTWHPEHFLCHHCDEQILDATFNVQSGEPVCNKCFVERYTYTCAGCK 70
            :|..|.:.|..:::||||:.||||||:|..|...:..::|..:.|.|.|.:|:.||::..|..|.
Human   227 LCGSCNKPIAGQVVTALGRAWHPEHFVCGGCSTALGGSSFFEKDGAPFCPECYFERFSPRCGFCN 291

  Fly    71 KPILEKTICAMGESWHEDCFCCGGACKKPLANQTFYERDGKPYCKKDYEDLFAARCAKCEKPITD 135
            :||..|.:.|:|..||.:.||| .:|.:|..::.|:||:|:|||::|:..|||.||..|:.||.|
Human   292 QPIRHKMVTALGTHWHPEHFCC-VSCGEPFGDEGFHEREGRPYCRRDFLQLFAPRCQGCQGPILD 355

  Fly   136 SAVLAMNVKWHRDCFRCNKCENPITSQTFTIDGDKPVC 173
            :.:.|::..||.|||.|.:|..|.:..:|.....:|:|
Human   356 NYISALSALWHPDCFVCRECFAPFSGGSFFEHEGRPLC 393

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31988	NP_001286122.1	LIM	7..58	CDD:295319	19/50 (38%)
		LIM	66..118	CDD:295319	21/51 (41%)
		LIM	126..176	CDD:259829	17/48 (35%)
TGFB1I1	NP_001035919.1	Interaction with PTK2B/PYK2	1..240		3/12 (25%)
		Transcription activation. /evidence=ECO:0000250	1..200
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..87
		LD motif 1	3..15
		Interaction with PTK2/FAK1. /evidence=ECO:0000250	83..136
		Paxillin	<86..>106	CDD:308898
		LD motif 2	92..104
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	116..152
		LD motif 3	157..168
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	172..205
		LD motif 4	203..215
		LIM1_Paxillin_like	228..280	CDD:259830	20/51 (39%)
		LIM2_Paxillin_like	287..338	CDD:188723	21/51 (41%)
		LIM3_Paxillin	346..398	CDD:188793	17/48 (35%)
		LIM4_Leupaxin	405..456	CDD:188796
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149723
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1703
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1593918at2759
OrthoFinder	1	1.000	-	-		FOG0000055
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X39
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.840