DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31988 and PXN

DIOPT Version :9

Sequence 1:	NP_001286122.1	Gene:	CG31988 / 326182	FlyBaseID:	FBgn0051988	Length:	178	Species:	Drosophila melanogaster
Sequence 2:	XP_016875215.1	Gene:	PXN / 5829	HGNCID:	9718	Length:	1135	Species:	Homo sapiens

Alignment Length:	168	Identity:	65/168 - (38%)
Similarity:	99/168 - (58%)	Gaps:	1/168 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 VCHKCQEAITKRMITALGKTWHPEHFLCHHCDEQILDATFNVQSGEPVCNKCFVERYTYTCAGCK 70
            ||..|::.|..:::||:|||||||||:|.||.|:|....|..:.|:|.|.|.:...::..|..|.
Human   901 VCGACKKPIAGQVVTAMGKTWHPEHFVCTHCQEEIGSRNFFERDGQPYCEKDYHNLFSPRCYYCN 965

  Fly    71 KPILEKTICAMGESWHEDCFCCGGACKKPLANQTFYERDGKPYCKKDYEDLFAARCAKCEKPITD 135
            .|||:|.:.|:..:||.:.|.| ..|......:.|:|:|||.||:|||.|:||.:|..|.:.|.:
Human   966 GPILDKVVTALDRTWHPEHFFC-AQCGAFFGPEGFHEKDGKAYCRKDYFDMFAPKCGGCARAILE 1029

  Fly   136 SAVLAMNVKWHRDCFRCNKCENPITSQTFTIDGDKPVC 173
            :.:.|:|..||.:||.|.:|..|..:.:|.....:|.|
Human  1030 NYISALNTLWHPECFVCRECFTPFVNGSFFEHDGQPYC 1067

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31988	NP_001286122.1	LIM	7..58	CDD:295319	24/50 (48%)
		LIM	66..118	CDD:295319	20/51 (39%)
		LIM	126..176	CDD:259829	15/48 (31%)
PXN	XP_016875215.1	Paxillin	60..259	CDD:281527
		LIM1_Paxillin_like	902..954	CDD:259830	24/51 (47%)
		LIM2_Paxillin	961..1012	CDD:188791	20/51 (39%)
		LIM3_Paxillin_like	1020..1072	CDD:188724	15/48 (31%)
		LIM4_Paxillin	1079..1130	CDD:188795
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149733
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1703
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1593918at2759
OrthoFinder	1	1.000	-	-		FOG0000055
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X39
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.840