Protein Alignment CG31988 and SYNPO2

DIOPT Version :9

• Sequence 1: NP_001286122.1
• Gene: CG31988 / 326182
• FlyBaseID: FBgn0051988
• Length: 178
• Species: Drosophila melanogaster
• Sequence 2: NP_597734.2
• Gene: SYNPO2 / 171024
• HGNCID: 17732
• Length: 1261
• Species: Homo sapiens
• Alignment Length: 16
• Identity: 8/16 - (50%)
• Similarity: 11/16 - (68%)
• Gaps: 0/16 - (0%)

  Fly   121 LFAARCAKCEKPITDS 136
            |||.|.::.||.:.||
Human   875 LFAKRQSRMEKYVVDS 890

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG31988	NP_001286122.1	LIM	7..58	CDD:295319
		LIM	66..118	CDD:295319
		LIM	126..176	CDD:259829	4/11 (36%)
SYNPO2	NP_597734.2	Interaction with VPS18. /evidence=ECO:0000269|PubMed:23434281	1..180
		PDZ_signaling	7..85	CDD:238492
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	144..174
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	211..233
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	329..369
		Nuclear localization signal. /evidence=ECO:0000250|UniProtKB:Q91YE8	398..406
		Interaction with ACTN2. /evidence=ECO:0000269|PubMed:20554076	481..663
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	507..803
		F-actin binding. /evidence=ECO:0000269|PubMed:23225103	534..663
		Interaction with YWHAB. /evidence=ECO:0000250|UniProtKB:Q91YE8	607..811
		Interaction with BAG3. /evidence=ECO:0000269|PubMed:23434281	615..626
		PPPY motif. /evidence=ECO:0000305|PubMed:23434281	619..622
		Interaction with ACTN2. /evidence=ECO:0000269|PubMed:20554076	664..924		8/16 (50%)
		F-actin bundling activity. /evidence=ECO:0000269|PubMed:23225103	664..916		8/16 (50%)
		F-actin binding. /evidence=ECO:0000269|PubMed:23225103	664..803
		Actin binding. /evidence=ECO:0000250|UniProtKB:Q91YE8	751..900		8/16 (50%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	834..870
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	937..956
		Interaction with ZYX. /evidence=ECO:0000269|PubMed:16885336	1000..1019
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1041..1064

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1703
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900