DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31988 and LDB3

DIOPT Version :9

Sequence 1:	NP_001286122.1	Gene:	CG31988 / 326182	FlyBaseID:	FBgn0051988	Length:	178	Species:	Drosophila melanogaster
Sequence 2:	NP_001165081.1	Gene:	LDB3 / 11155	HGNCID:	15710	Length:	732	Species:	Homo sapiens

Alignment Length:	170	Identity:	59/170 - (34%)
Similarity:	90/170 - (52%)	Gaps:	3/170 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 VCHKCQEAITKRMITALGKTWHPEHFLCHHCDEQILDATFNVQSGEPVCNKCFVERYTYTCAGCK 70
            :|..|...|....:.|:|::||||.|.|.:|...:.|..|..:.....|.:|:.:.:...||.|.
Human   555 LCGHCNNVIRGPFLVAMGRSWHPEEFTCAYCKTSLADVCFVEEQNNVYCERCYEQFFAPLCAKCN 619

  Fly    71 KPILEKTICAMGESWHEDCFCCGGACKKPLANQTFYERDGKPYCKKDYEDLFAARCAKCEKPIT- 134
            ..|:.:.:.|:.::||..||.| .|||||..|..|:..||:|||:|||.:||:.:|..|:.|:.
Human   620 TKIMGEVMHALRQTWHTTCFVC-AACKKPFGNSLFHMEDGEPYCEKDYINLFSTKCHGCDFPVEA 683

  Fly   135 -DSAVLAMNVKWHRDCFRCNKCENPITSQTFTIDGDKPVC 173
             |..:.|:...||..||.|..|...:..|.|....|:|:|
Human   684 GDKFIEALGHTWHDTCFICAVCHVNLEGQPFYSKKDRPLC 723

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31988	NP_001286122.1	LIM	7..58	CDD:295319	15/50 (30%)
		LIM	66..118	CDD:295319	23/51 (45%)
		LIM	126..176	CDD:259829	16/50 (32%)
LDB3	NP_001165081.1	PDZ_signaling	5..81	CDD:238492
		DUF4045	<77..180	CDD:330572
		ZM	189..214	CDD:128974
		DUF4749	263..353	CDD:318205
		Atrophin-1	<387..554	CDD:331285
		LIM1_ZASP_Cypher	556..607	CDD:188838	15/50 (30%)
		LIM2_Enigma_like	615..666	CDD:188748	23/51 (45%)
		LIM3_Enigma_like	674..727	CDD:188749	16/50 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1703
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000055
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.900