DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31988 and PDLIM5

DIOPT Version :9

Sequence 1:	NP_001286122.1	Gene:	CG31988 / 326182	FlyBaseID:	FBgn0051988	Length:	178	Species:	Drosophila melanogaster
Sequence 2:	NP_001243355.2	Gene:	PDLIM5 / 10611	HGNCID:	17468	Length:	625	Species:	Homo sapiens

Alignment Length:	170	Identity:	65/170 - (38%)
Similarity:	89/170 - (52%)	Gaps:	3/170 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 VCHKCQEAITKRMITALGKTWHPEHFLCHHCDEQILDATFNVQSGEPVCNKCFVERYTYTCAGCK 70
            :|..|.:.|....:.||||:||||.|.|.||...:....|..:.|...|..|:.:.:...|..|:
Human   448 MCAHCNQVIRGPFLVALGKSWHPEEFNCAHCKNTMAYIGFVEEKGALYCELCYEKFFAPECGRCQ 512

  Fly    71 KPILEKTICAMGESWHEDCFCCGGACKKPLANQTFYERDGKPYCKKDYEDLFAARCAKCEKPIT- 134
            :.||.:.|.|:.::||..||.| .||.||:.|..|:..||:|||:.||..||...|..||.||.
Human   513 RKILGEVISALKQTWHVSCFVC-VACGKPIRNNVFHLEDGEPYCETDYYALFGTICHGCEFPIEA 576

  Fly   135 -DSAVLAMNVKWHRDCFRCNKCENPITSQTFTIDGDKPVC 173
             |..:.|:...||..||.|:.|...:..|||....|||:|
Human   577 GDMFLEALGYTWHDTCFVCSVCCESLEGQTFFSKKDKPLC 616

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31988	NP_001286122.1	LIM	7..58	CDD:295319	18/50 (36%)
		LIM	66..118	CDD:295319	22/51 (43%)
		LIM	126..176	CDD:259829	20/50 (40%)
PDLIM5	NP_001243355.2	PDZ_signaling	10..82	CDD:238492
		DUF4749	105..201	CDD:406377
		LIM1_ENH	449..500	CDD:188837	18/50 (36%)
		LIM	508..559	CDD:413332	22/51 (43%)
		LIM3_ENH	567..621	CDD:188843	20/50 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1703
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000055
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X39
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.900