DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31937 and dhrs7

DIOPT Version :9

Sequence 1:	NP_608616.2	Gene:	CG31937 / 326177	FlyBaseID:	FBgn0031360	Length:	321	Species:	Drosophila melanogaster
Sequence 2:	NP_001038811.1	Gene:	dhrs7 / 751626	ZFINID:	ZDB-GENE-060825-21	Length:	338	Species:	Danio rerio

Alignment Length:	312	Identity:	116/312 - (37%)
Similarity:	177/312 - (56%)	Gaps:	9/312 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 LYYVVYVLLWILLDCNVALWYKSRFG-VSLSSMRGQVVWITGASSGIGRALALSLARHGVKLVLS 76
            :|.:|..:.:|..|.::.|.:.:||| ...|:.||:||||||||||||..|:|.||..|.:||||
Zfish    15 VYLLVQFIRFIFADADLTLLWAARFGKTPESTFRGKVVWITGASSGIGEELSLQLAAIGARLVLS 79

  Fly    77 ARRLEQLEQVQEECLAAARGLLATKDVLVIQMDMLDLDEHKTHLNTVLNHFHRLDVLVNNAGRSQ 141
            |||..:||:|:..||  .|..|..:|:||:.:|::|...|.......|.||..:|||:||.||||
Zfish    80 ARRENELERVKRLCL--ERSSLKAEDILVLPLDLMDRASHPEKTTAALEHFGEIDVLINNGGRSQ 142

  Fly   142 RASWTEVEIEVDRELFELDVFAVVHLSRLVVRYFVEQNGGRGHIAATSSIAGFSPVPFSPTYCAA 206
            ||...:.:::|.:.|.||:....|.:::.|:.:.:::  |.|.||..||:|||..||.:..|.|:
Zfish   143 RALCVDADVDVYQALMELNYLGTVSITKQVLPHMIQR--GTGIIATVSSVAGFVGVPLATGYAAS 205

  Fly   207 KHALNAYLLSLKVEMR---KLDVSLFAPGPIATDFLQEAFTGSQGGKVGLSTANQKRMTAQRCGD 268
            ||||..:..||:.|:.   .:.:|...|||:.:..:|.|||...|..|..:.....:|:.:||..
Zfish   206 KHALQGFFNSLRTELSDCPNILISNICPGPVISSIVQNAFTEELGKPVATAGDQTHKMSTERCVH 270

  Fly   269 LFAVALANKMDLTWCGLFPVNLLAYCAR-NPTLSKILAQLMTEKTLNKIREG 319
            |..|.|||::...|....|..|..|..: .|||:..|..::.:|.:...:.|
Zfish   271 LTLVGLANRVKEMWIAEQPFLLFCYVWQYTPTLAWYLTNVLGKKRVQNFKAG 322

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31937	NP_608616.2	NADB_Rossmann	44..293	CDD:304358	100/251 (40%)
CG31937	NP_608616.2	adh_short	47..245	CDD:278532	84/200 (42%)
dhrs7	NP_001038811.1	11beta-HSD1_like_SDR_c	47..307	CDD:187593	104/263 (40%)
dhrs7	NP_001038811.1	adh_short	50..249	CDD:278532	85/202 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170596750
Domainoid	1	1.000	152	1.000	Domainoid score	I4299
eggNOG	1	0.900	-	-		E2759_KOG1205
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H9350
Inparanoid	1	1.050	197	1.000	Inparanoid score	I3787
OMA	1	1.010	-	-		QHG59790
OrthoDB	1	1.010	-	-		D429842at33208
OrthoFinder	1	1.000	-	-		FOG0004121
OrthoInspector	1	1.000	-	-		oto40137
orthoMCL	1	0.900	-	-		OOG6_104960
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5576
SonicParanoid	1	1.000	-	-		X68
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.700