DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31937 and HSD11B1L

DIOPT Version :9

Sequence 1:	NP_608616.2	Gene:	CG31937 / 326177	FlyBaseID:	FBgn0031360	Length:	321	Species:	Drosophila melanogaster
Sequence 2:	NP_001254797.1	Gene:	HSD11B1L / 374875	HGNCID:	30419	Length:	333	Species:	Homo sapiens

Alignment Length:	226	Identity:	65/226 - (28%)
Similarity:	96/226 - (42%)	Gaps:	46/226 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 SSMRGQVVWITGASSGIGRALALSLARHGVKLVLSARRLEQLEQVQEECLAAARGLLATKDVLVI 106
            :|::|..|.:|||::|:|..||...||.|..|||:|.....|::|...|    |.|.|.| |..|
Human    72 ASLQGARVLLTGANAGVGEELAYHYARLGSHLVLTAHTEALLQKVVGNC----RKLGAPK-VFYI 131

  Fly   107 QMDMLDLDEHKTHLNTVLNHFHRLDVLVNN------AGRSQRASWTEVEIEVDRELFELDVFAVV 165
            ..||...:..::.:...|:....||.||.|      ||...|:.      :..|.|.:::..:.|
Human   132 AADMASPEAPESVVQFALDKLGGLDYLVLNHIGGAPAGTRARSP------QATRWLMQVNFVSYV 190

  Fly   166 HLSRLVVRYFVEQNGGRGHIAATSSIAGFSPVPFSPTYCAAKHALNAYLLSLKVEMRKLDVSL-- 228
            .|:.   |........:|.:...||:.|..|..||..|.|||.||:.:..||:.|:...||::
Human   191 QLTS---RALPSLTDSKGSLVVVSSLLGRVPTSFSTPYSAAKFALDGFFGSLRRELDVQDVNVAI 252

  Fly   229 ------------------------FAPGPIA 235
                                    .||||.|
Human   253 TMCVLGLRDRASAAEAVRGVTRVKAAPGPKA 283

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31937	NP_608616.2	NADB_Rossmann	44..293	CDD:304358	64/224 (29%)
CG31937	NP_608616.2	adh_short	47..245	CDD:278532	63/221 (29%)
HSD11B1L	NP_001254797.1	GVQW	3..>26	CDD:290611
		NADB_Rossmann	74..302	CDD:304358	64/224 (29%)
		PRK08251	78..302	CDD:181324	63/220 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1205
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D906746at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820