DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31933 and R03G8.1

DIOPT Version :9

Sequence 1:	NP_722734.1	Gene:	CG31933 / 326176	FlyBaseID:	FBgn0051933	Length:	673	Species:	Drosophila melanogaster
Sequence 2:	NP_510172.2	Gene:	R03G8.1 / 187544	WormBaseID:	WBGene00010996	Length:	663	Species:	Caenorhabditis elegans

Alignment Length:	733	Identity:	162/733 - (22%)
Similarity:	275/733 - (37%)	Gaps:	185/733 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 ILYALLFLDTQCYETGGKIHNAFFV----------NTDGCRIIAMDVMNPTIAKYTDWEWKDKRF 73
            |||.|:.: ...|.....||..:..          :.|.|.:...||            |.::.|
Worm    17 ILYILVCI-AFTYSVSIVIHTDYAAPVTEDILVGNSWDTCELPRYDV------------WDEELF 68

  Fly    74 -YL--------KCPHQTWFR--TEVANGDWYLKLTRDIDRILQESDLTHDWQIKCYW---FRIKI 124
             ||        ||  .|.|:  |::.|..|.:....::           ..:.:|:.   .:..:
Worm    69 GYLNPNENPLKKC--DTSFKPLTKLENSKWGVTFAHNL-----------TCRARCHTRKRDKENL 120

  Fly   125 KGRWRAKIYGPTMFPLEYPYALKVPKGLRHMRVKCLNTFTNKTLHDDAHFFIQPPPEKLLKKPPA 189
            .|.|   .|.|.....|....:...||           ...:.::...|..|.|...| |.:..|
Worm   121 VGNW---TYTPGKINCEILETVCAEKG-----------GEQRDVYGYLHSQIIPTKPK-LSRTNA 170

  Fly   190 TLKYWDGEKHSSGATSPISVMILGLDSVSHLNLLRQMPRTVRYMRQNMSQVEFWGFNKIGTNTYP 254
            .||.:|             |.::.|||:|:....|.:||||.:.:..|..:.|...||:|.|:.|
Worm   171 DLKEYD-------------VFVILLDSLSYSQAARSLPRTVSFFKSYMKGIIFPYMNKVGDNSRP 222

  Fly   255 NLIALLTG----------LSAAESEAYWVRQK-C---MDNLPLIWKEFKRAGYNTSFAEDMAIYS 305
            |.:||..|          ......||.|.... |   .||...::.|||..||.|..|||.|:.:
Worm   223 NGVALWFGKLLEKVDRFIFDKPSLEADWTDDYFCNVFKDNETSLFDEFKTHGYKTLMAEDWALGT 287

  Fly   306 MFYFGKPGFKRPTTDNNLHDFMVDLYINRQASSVSDTHCMGE-------------RAFMDILLEM 357
            :.:....|::..:.|:.:..|  .|...:..:.|:..|..|.             ..|:|.....
Worm   288 LIWPNCLGYRNQSIDHYMRPF--QLAHEKYGTPVTREHLNGSLCREDHNTLLDYLAQFLDAYSGS 350

  Fly   358 NDRLLPHTQRYP------FFSFYWWA-------NGF--------HEFFNSPRLADGRFERLLRSL 401
            ||.:....::.|      .|:|.|..       |||        ::|.|.       |.:..:.|
Worm   351 NDSIQLKREKSPNSPDQRKFAFLWTTRLGHATENGFDATENGSDNDFLNF-------FIKHRKKL 408

  Fly   402 DDAGITNNTIIFFMSDHGLRWGLFRSSFQGMIEDSQPFLSVLYPKWMRLKYPMAIKSLVGNAHSL 466
            :|      :.:..:.|||.|.|..|::..|.|:.:.|..::..|..:|....: :|.|..|:..|
Worm   409 ED------SFVLLLGDHGFRLGGVRNTAVGAIDVNNPLTAISVPNSLRTNTDI-LKILNMNSEKL 466

  Fly   467 VTTYDLHETLKHILEPSSLEDTSITQKTEELWKLKGSQTP--RAVSLFLPIPPW-RNCNTSHIPS 528
            .|.:|...|:..||:         .|..|:...:...|.|  :..|.....||: |||.|..||.
Worm   467 QTHFDTRATILDILK---------FQPAEKFSAITPLQIPGEKGQSHLRNQPPFNRNCQTMPIPF 522

  Fly   529 KFCLCH-KQIPIPESNRVVTKSASIIIDYVNQLMVEYPVCIPLQLDSIESAYFAAP-QRDDDF-- 589
            ::|:|. .:..:|.::.:..:....:.:.||:|         ||:::..|...:.. :|.:..
Worm   523 EYCICQFNKTSVPINSTISMEIGEKVAENVNKL---------LQINNFTSECISMVFERTESLLQ 578

  Fly   590 YIEK-GHKNVYPEKGPFWKKQKYEDRDIVVRLKTKPGNAYFEGMTRRQGSKLSLVGEVVRVGGEG 653
            |.:| |:..:|               .::.::| ||..|.|:...:.....:.:|.:|.||...|
Worm   579 YNQKLGNSTIY---------------TVIAQMK-KPSEAKFKATVKITEGNIKIVSKVERVDSYG 627

  Fly   654 NRNNDCIDNPLLEPFCHC 671
             :..|||::....|.|:|
Worm   628 -KTADCIESETHRPICYC 644

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31933	NP_722734.1	DUF229	114..576	CDD:281053	118/516 (23%)
CG31933	NP_722734.1	ALP_like	208..483	CDD:293745	80/322 (25%)
R03G8.1	NP_510172.2	DUF229	74..651	CDD:281053	147/663 (22%)
R03G8.1	NP_510172.2	ALP_like	175..483	CDD:293745	81/345 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG28588
OrthoDB	1	1.010	-	-		D306348at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10974
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	5	4.990