DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31933 and Y41E3.1

DIOPT Version :9

Sequence 1:	NP_722734.1	Gene:	CG31933 / 326176	FlyBaseID:	FBgn0051933	Length:	673	Species:	Drosophila melanogaster
Sequence 2:	NP_001041024.1	Gene:	Y41E3.1 / 178413	WormBaseID:	WBGene00012762	Length:	682	Species:	Caenorhabditis elegans

Alignment Length:	679	Identity:	158/679 - (23%)
Similarity:	275/679 - (40%)	Gaps:	144/679 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 QCYETGGKIHNAFFVNTDGCRIIAMDVMNPTIAKYTDWEWKDKRFYLKCPHQTWFRTEVANGDWY 93
            :|.:......|..|:|.:            .|.::|     :||...||..|.:.|.:..|..:.
Worm   108 ECQKKNSIEDNWVFINDE------------AIIRFT-----EKRAKAKCKIQYFSRVDDNNNKYE 155

  Fly    94 LKL-TRDIDRILQESDLTHDWQIKCYWFRIKIKG--RWRAKIYGPTMFPLEYPYALKVPKGLRHM 155
            ..: ..|.|| :..||..   .|.|      |:|  :|::.::.....|       ::.:..|.|
Worm   156 EPVEVLDGDR-MNGSDYA---TISC------IQGFQKWKSILWDVNDEP-------EIHERARKM 203

  Fly   156 RVKCLNTFTNKTLHDDAHFFIQPPPEKLLKKPPATLKYWDGEKHSSGATSPISVMILGLDSVSHL 220
            |.:                  |..|||                      .|.:|..||.||:|.:
Worm   204 RKE------------------QADPEK----------------------KPYNVYFLGFDSLSQM 228

  Fly   221 NLLRQMPRTVRYMRQNMSQVEFWGFNKIGTNTYPNLIALLTGLSAAESEAYWVRQKCM------D 279
            :..|::|:||:::.:.:..|...|:|.:|..|....|.:||  :..|:|....|::..      |
Worm   229 SFRRKLPQTVKFLEETLGSVVLNGYNIVGDGTPQAFIPILT--AQTETELPLTRKRYKNANYVDD 291

  Fly   280 NLPLIWKEFKRAGYNTSFAEDMAIYSMFYFGKPGFKRPTTDNNLHDFMVDLYINRQASSVSDTHC 344
            ..|.|||.:...||.|.:|||......|.:...||::..||:......      .:...::|.:|
Worm   292 VYPFIWKNYSDKGYVTMYAEDAFSIGTFTYRLKGFRQQPTDHYTRTLF------EEVEKLNDRNC 350

  Fly   345 MGERAFMDILLEMNDRLLPHTQRYPFFSFYWWANGFHEFFNSPRLADGRFERLLRSLDDAGITNN 409
            :|......:.|:...:.:...:..|.|.....:...|:..|...:.|......|..::|.|:.::
Worm   351 IGSIPLHRMWLQNGRQFMKKYEDVPRFLLMHQSLLSHDDINLVGVEDEDLSAHLSHMNDEGLFDD 415

  Fly   410 TIIFFMSDHGLRWGLFRSSFQGMIEDSQPFLSVLYPKWMR--LKYPMAIKSLVGNAHSLVTTYDL 472
            :::..|:|||.|:...|.:.||.:|:..||.|:..||.:|  .|.....::|..||..|.:.:|:
Worm   416 SVVIVMADHGHRFAKLRDTHQGQLEERMPFFSISLPKQLRNTEKGRKMEQNLRENAEKLTSPFDI 480

  Fly   473 HETLKHILEPSSLEDTSITQKTEELWKLKGSQTPRAVSLFLPIPPWRNCNTSHIPSKFCLC---H 534
            |.:|..||..|.|.:       .||.:::.:.:.|::|:|.|||..|.|:.:.|...:|.|   .
Worm   481 HASLMDILNLSELGE-------NELNRMQDASSKRSLSVFKPIPVDRTCSQAGIEPHWCTCLSWK 538

  Fly   535 KQIPIPESNRVVTKSASIIIDYVN-QLMVEYPVCIPLQLDSIESAYFAAPQRDDDFYIEKGHKNV 598
            ..:...|..::..:.|:.::..:| :::.|..:|.||.|..|..|                 |.:
Worm   539 DAMDTGEDRKLTRRIANAVVREINKEIVAEKDLCAPLSLAKIIDA-----------------KKL 586

  Fly   599 YPEKGPF-WKKQKYEDRDI--------------VVRLKTKPGNAYFEGMTR-----RQGSKLSLV 643
            .|:||.. :|..|..|..:              .::|:|.||.|.:| :|.     |...||..
Worm   587 LPDKGLLAYKNVKDADGFVPDLSGSTKAAFAHYQLKLQTTPGEAIYE-VTLFYDIVRDEVKLDF- 649

  Fly   644 GEVVRVGGEGNRNNDCID-NPLLEPFCHC 671
            |.:..|...|:..:..|| |..|..||.|
Worm   650 GSMSHVNKFGDTPHCIIDKNYYLATFCVC 678

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31933	NP_722734.1	DUF229	114..576	CDD:281053	111/475 (23%)
CG31933	NP_722734.1	ALP_like	208..483	CDD:293745	74/282 (26%)
Y41E3.1	NP_001041024.1	DUF229	78..581	CDD:281053	129/561 (23%)
Y41E3.1	NP_001041024.1	ALP_like	215..491	CDD:293745	74/283 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160162099
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840