Protein Alignment CG31928 and BACE2

DIOPT Version :10

• Sequence 1: NP_722705.1
• Gene: CG31928 / 326175
• FlyBaseID: FBgn0051928
• Length: 418
• Species: Drosophila melanogaster
• Sequence 2: NP_036237.2
• Gene: BACE2 / 25825
• HGNCID: 934
• Length: 518
• Species: Homo sapiens
• Alignment Length: 382
• Identity: 103/382 - (26%)
• Similarity: 166/382 - (43%)
• Gaps: 82/382 - (21%)

  Fly    82 ENLINSHNTEYYVTAGFGTPKSQPVTLLVDTASANLLVYSSEFVKQSCLHHDGYNSSE-SQTYQA 145
            :||.......||:....||| .|.:.:||||.|:|..|..:..     .:.|.|..:| |.||::
Human    82 DNLQGDSGRGYYLEMLIGTP-PQKLQILVDTGSSNFAVAGTPH-----SYIDTYFDTERSSTYRS 140

  Fly   146 NGSPFQIQFASQEILTGILSTDTFTLGDLVIKNQTFAEINSAPTDMCKRSNF-------DGIIGL 203
            .|....::: :|...||.:..|..|:....  |.:|. :|.|  .:.:..||       :||:||
Human   141 KGFDVTVKY-TQGSWTGFVGEDLVTIPKGF--NTSFL-VNIA--TIFESENFFLPGIKWNGILGL 199

  Fly   204 GFSEIA--LNGVETPLDNILEQGLIDEPIFSLYVNRN----ASDASNGGVLLLGGSDPTLYSGCL 262
            .::.:|  .:.:||..|:::.|..|.. :||:.:...    |...:|||.|:|||.:|:||.|.:
Human   200 AYATLAKPSSSLETFFDSLVTQANIPN-VFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDI 263

  Fly   263 TYVPVSKVGFWQITVGQVEIGSKKLCSNC------QAIFDMGTSLIIVPCPALKIINKKLG---- 317
            .|.|:.:..::||.:.::|||.:.|..:|      :||.|.||:|:.:|......:.:.:.
Human   264 WYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASL 328

  Fly   318 IKETDRKDGVYI---IDC-----KKVSHLPKIVFNIGWKD--------FTLNPSDYI-------L 359
            |.|.  .||.:.   :.|     ...|:.|||  :|..:|        .|:.|..||       |
Human   329 IPEF--SDGFWTGSQLACWTNSETPWSYFPKI--SIYLRDENSSRSFRITILPQLYIQPMMGAGL 389

  Fly   360 NYSGTCVS-GFSSLSDCNGTQTNDDSEDLNNIWVFGDVFFGAIFTLFDFGLKLVGMA 415
            ||.  |.. |.|..:               |..|.|.......:.:||...|.||.|
Human   390 NYE--CYRFGISPST---------------NALVIGATVMEGFYVIFDRAQKRVGFA 429

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG31928	NP_722705.1	Asp	91..416	CDD:394983	101/373 (27%)
BACE2	NP_036237.2	beta_secretase_like	89..450	CDD:133140	101/375 (27%)