DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31926 and bace1

DIOPT Version :9

Sequence 1:	NP_001259870.1	Gene:	CG31926 / 326174	FlyBaseID:	FBgn0051926	Length:	410	Species:	Drosophila melanogaster
Sequence 2:	NP_991267.1	Gene:	bace1 / 403005	ZFINID:	ZDB-GENE-040426-1835	Length:	505	Species:	Danio rerio

Alignment Length:	374	Identity:	95/374 - (25%)
Similarity:	161/374 - (43%)	Gaps:	59/374 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    77 SKVATLENLYNTE---YYTTLGFGNPPQDLKVLIDTGSANLWVLSSKCPDSVAPCANRIKYNSSA 138
            |.:..::||....   ||..:..|:|.|.|.:|:||||:|..|.:     :..|..:|. |:.|.
Zfish    64 SFINMIDNLRGKSGQGYYIEMAVGSPAQRLNILVDTGSSNFAVGA-----AAHPFLHRY-YHRSL 122

  Fly   139 STTYRAINTAFNIAYGSNSEEGPIALSGFQSQDTVNF---AGYSIKNQIFAEITNAPETAFLKSQ 200
            |::||.:.....:.|.....||.:      ..|.|:.   ...|::..| |.||.:.......|.
Zfish   123 SSSYRDLGRGVYVPYTQGRWEGEL------GTDVVSVPCGPNVSLRANI-AAITQSDRFFINGSN 180

  Fly   201 LDGILGLGFASIA--INSITPPFYNLMAQGLVNRSVFSIYL-----NRN---GTNAINGGELILG 255
            .:|||||.:|.||  ..::.|.|.:|:.|..| ..|||:.|     |.|   |:::..||.:|:|
Zfish   181 WEGILGLAYAEIARPDETLEPFFDSLLRQSTV-ADVFSLQLCGAGYNHNYSTGSSSTVGGSMIIG 244

  Fly   256 GSDSGLYSGCLTYVPVSSAGYWQFTMTSANLNGFQFCENC------EAILDVGTSLIVVPEQVLD 314
            |.|..||.|.|.|.|:....|::..:....:||.....:|      ::|:|.||:.:.:|.:|..
Zfish   245 GVDPSLYVGELWYTPIRREWYYEVIIVRIEVNGQDLNMDCKEYNYDKSIVDSGTTNLRLPRKVFQ 309

  Fly   315 TINQILGVLNPTAS--NGVFLVD---CSSIGDLPDIVFTV---------ARRKFP--------LK 357
            ...:.:...:.|..  :|.:|.:   |...|..|..:|.|         ..:.|.        |:
Zfish   310 AAVKAIEAASSTEQFPSGFWLGEQLVCWQAGTTPWHIFPVISLYLMSENRNQSFRISILPQQYLR 374

  Fly   358 SSDYVLRYGNTCVSGFTSMNGNSLLILGEIFLGAYYTTYDIVYKLIGLA 406
            ..:.|......|.. |.....::..::|.:.:..:|..::..:|.||.|
Zfish   375 PVEDVASAQEDCYK-FAVSQSSTGTVMGAVIMEGFYVVFERQHKRIGFA 422

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31926	NP_001259870.1	pepsin_retropepsin_like	82..406	CDD:299705	93/367 (25%)
CG31926	NP_001259870.1	Asp	89..408	CDD:278455	92/362 (25%)
bace1	NP_991267.1	beta_secretase_like	77..443	CDD:133140	92/361 (25%)
bace1	NP_991267.1	Asp	80..422	CDD:278455	91/356 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D753343at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.920