DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31926 and Bace1

DIOPT Version :9

Sequence 1:	NP_001259870.1	Gene:	CG31926 / 326174	FlyBaseID:	FBgn0051926	Length:	410	Species:	Drosophila melanogaster
Sequence 2:	NP_062077.1	Gene:	Bace1 / 29392	RGDID:	2191	Length:	501	Species:	Rattus norvegicus

Alignment Length:	453	Identity:	108/453 - (23%)
Similarity:	189/453 - (41%)	Gaps:	90/453 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 VRWNHFKLLLFWL--TVLAVLAFEAEARKRVRIGLHKNPEPIEENIKNELKTLSIKHNLNVDDTK 65
            :||     ||.|:  .:|.........|..:|.||...|             |.::       ..
  Rat     5 LRW-----LLLWVGSGMLPAQGTHLGIRLPLRSGLAGPP-------------LGLR-------LP 44

  Fly    66 AKTKTDTKVPGSKVATLENLYNTE------YYTTLGFGNPPQDLKVLIDTGSANLWVLSSKCPDS 124
            .:|..:.:.||.:.:.:|.:.|..      ||..:..|:|||.|.:|:||||:|..|  ...|.
  Rat    45 RETDEEPEEPGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAV--GAAPH- 106

  Fly   125 VAPCANRIKYNSSASTTYRAINTAFNIAYGSNSEEGPIALSGFQSQDTVNF---AGYSIKNQIFA 186
              |..:|. |....|:|||.:..:..:.|.....||.:      ..|.|:.   ...:::..| |
  Rat   107 --PFLHRY-YQRQLSSTYRDLRKSVYVPYTQGKWEGEL------GTDLVSIPHGPNVTVRANI-A 161

  Fly   187 EITNAPETAFLKSQLDGILGLGFASIA--INSITPPFYNLMAQGLVNRSVFSIY-------LNRN 242
            .||.:.:.....|..:|||||.:|.||  .:|:.|.|.:|:.|..: .::||:.       ||:.
  Rat   162 AITESDKFFINGSNWEGILGLAYAEIARPDDSLEPFFDSLVKQTHI-PNIFSLQLCGAGFPLNQT 225

  Fly   243 GTNAINGGELILGGSDSGLYSGCLTYVPVSSAGYWQFTMTSANLNGFQFCENC------EAILDV 301
            ...|..||.:|:||.|..||:|.|.|.|:....|::..:....:||.....:|      ::|:|.
  Rat   226 EALASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDS 290

  Fly   302 GTSLIVVPEQVLDTINQILGVLNPTAS--NGVFLVD---CSSIGDLPDIVF-------------- 347
            ||:.:.:|::|.:...:.:...:.|..  :|.:|.:   |...|..|..:|
  Rat   291 GTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQ 355

  Fly   348 ----TVARRKFPLKSSDYVLRYGNTCVSGFTSMNGNSLLILGEIFLGAYYTTYDIVYKLIGLA 406
                |:..::: |:..:.|....:.|.. |.....::..::|.:.:..:|..:|...|.||.|
  Rat   356 SFRITILPQQY-LRPVEDVATSQDDCYK-FAVSQSSTGTVMGAVIMEGFYVVFDRARKRIGFA 416

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31926	NP_001259870.1	pepsin_retropepsin_like	82..406	CDD:299705	92/370 (25%)
CG31926	NP_001259870.1	Asp	89..408	CDD:278455	91/365 (25%)
Bace1	NP_062077.1	beta_secretase_like	72..437	CDD:133140	91/361 (25%)
		Interaction with RTN3. /evidence=ECO:0000250	479..501
		DXXLL. /evidence=ECO:0000250\|UniProtKB:P56817	496..500
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1339
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D753343at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820