Protein Alignment CG31926 and CTSD

DIOPT Version :9

• Sequence 1: NP_001259870.1
• Gene: CG31926 / 326174
• FlyBaseID: FBgn0051926
• Length: 410
• Species: Drosophila melanogaster
• Sequence 2: NP_001900.1
• Gene: CTSD / 1509
• HGNCID: 2529
• Length: 412
• Species: Homo sapiens
• Alignment Length: 427
• Identity: 153/427 - (35%)
• Similarity: 219/427 - (51%)
• Gaps: 56/427 - (13%)

  Fly    15 LTVLAVLAFEAEARKRVRIGLHKNPEPIEENIKNELKTLSIKHNL-----NVDDTKAK---TKTD 71
            |..||:....|.|...|||.||              |..||:..:     :|:|..||   :|..
Human     6 LLPLALCLLAAPASALVRIPLH--------------KFTSIRRTMSEVGGSVEDLIAKGPVSKYS 56

  Fly    72 TKVP----GSKVATLENLYNTEYYTTLGFGNPPQDLKVLIDTGSANLWVLSSKCPDSVAPCANRI 132
            ..||    |.....|:|..:.:||..:|.|.|||...|:.||||:||||.|..|......|....
Human    57 QAVPAVTEGPIPEVLKNYMDAQYYGEIGIGTPPQCFTVVFDTGSSNLWVPSIHCKLLDIACWIHH 121

  Fly   133 KYNSSASTTYRAINTAFNIAYGSNSEEGPIALSGFQSQDTVN-----------FAGYSIKNQIFA 186
            ||||..|:||....|:|:|.|||.|      |||:.|||||:           ..|..::.|:|.
Human   122 KYNSDKSSTYVKNGTSFDIHYGSGS------LSGYLSQDTVSVPCQSASSASALGGVKVERQVFG 180

  Fly   187 EITNAPETAFLKSQLDGILGLGFASIAINSITPPFYNLMAQGLVNRSVFSIYLNRNGTNAINGGE 251
            |.|..|...|:.::.|||||:.:..|::|::.|.|.|||.|.||::::||.||:|: .:|..|||
Human   181 EATKQPGITFIAAKFDGILGMAYPRISVNNVLPVFDNLMQQKLVDQNIFSFYLSRD-PDAQPGGE 244

  Fly   252 LILGGSDSGLYSGCLTYVPVSSAGYWQFTMTSANL-NGFQFC-ENCEAILDVGTSLIVVPEQVLD 314
            |:|||:||..|.|.|:|:.|:...|||..:....: :|...| |.||||:|.||||:|.|...:.
Human   245 LMLGGTDSKYYKGSLSYLNVTRKAYWQVHLDQVEVASGLTLCKEGCEAIVDTGTSLMVGPVDEVR 309

  Fly   315 TINQILGVLNPTASNGVFLVDCSSIGDLPDIVFTVARRKFPLKSSDYVLRY---GNT-CVSGFTS 375
            .:.:.:|.:  ....|.:::.|..:..||.|...:..:.:.|...||.|:.   |.| |:|||..
Human   310 ELQKAIGAV--PLIQGEYMIPCEKVSTLPAITLKLGGKGYKLSPEDYTLKVSQAGKTLCLSGFMG 372

  Fly   376 MN----GNSLLILGEIFLGAYYTTYDIVYKLIGLAPA 408
            |:    ...|.|||::|:|.|||.:|.....:|.|.|
Human   373 MDIPPPSGPLWILGDVFIGRYYTVFDRDNNRVGFAEA 409

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG31926	NP_001259870.1	pepsin_retropepsin_like	82..406	CDD:299705	130/344 (38%)
		Asp	89..408	CDD:278455	129/339 (38%)
CTSD	NP_001900.1	A1_Propeptide	22..49	CDD:400357	10/40 (25%)
		Cathepsin_D2	73..408	CDD:133157	129/343 (38%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1339
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54317
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000066
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR47966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	6	5.880