DRSC/TRiP Functional Genomics Resources

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Protein Alignment Nepl3 and ECE2

DIOPT Version :9

Sequence 1:NP_608904.1 Gene:Nepl3 / 326172 FlyBaseID:FBgn0031678 Length:629 Species:Drosophila melanogaster
Sequence 2:NP_001093590.1 Gene:ECE2 / 9718 HGNCID:13275 Length:811 Species:Homo sapiens


Alignment Length:703 Identity:137/703 - (19%)
Similarity:230/703 - (32%) Gaps:237/703 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MMESRSYLSL-----SWL---LLLLC-------------STVCSANPNLEIMKRMLDDMDEKVEP 44
            ::.||:.|.|     |.|   |||.|             .:.|.....:.:..::|:.:|..|.|
Human    98 LLGSRTQLELVLAGASLLLAALLLGCLVALGVQYHRDPSHSTCLTEACIRVAGKILESLDRGVSP 162

  Fly    45 CHNFYNSS-----QKN------LKWHAFATVSDQFQ-LLFDGIENEVFEKHS-FEEKLQRLYKIC 96
            |.:||..|     ::|      .:|:.|.::.||.| :|...:||..|...| .|:|.||.|..|
Human   163 CEDFYQFSCGGWIRRNPLPDGRSRWNTFNSLWDQNQAILKHLLENTTFNSSSEAEQKTQRFYLSC 227

  Fly    97 STMERPSLLRYFELVKPGEDL-----NWPFLTPRGGKWPKEKFQWMEALARLRRYGFNDIMFGMS 156
            ..:||...|.    .:|..||     .|...    |.|.::.|  ||.|..:.........|.:.
Human   228 LQVERIEELG----AQPLRDLIEKIGGWNIT----GPWDQDNF--MEVLKAVAGTYRATPFFTVY 282

  Fly   157 IRQDPNSDSGQPIVV------------------FEKKYDSLFRFIESL----------------Q 187
            |..|..|.:...|.|                  .||...:...::|.|                |
Human   283 ISADSKSSNSNVIQVDQSGLFLPSRDYYLNRTANEKVLTAYLDYMEELGMLLGGRPTSTREQMQQ 347

  Fly   188 NIGLPPKLAKEIAPLDNAIQEMYKSDMKFEHYARDAAPVKRISLGQLEIYGVS---------LTK 243
            .:.|..:||....|     |:..:.:.|..|         ::|:.:|:....|         |..
Human   348 VLELEIQLANITVP-----QDQRRDEEKIYH---------KMSISELQALAPSMDWLEFLSFLLS 398

  Fly   244 YLEIVFGRPFSPDFVVHVENLYYLRGLQNLMTAVPSQVVANYLTARFSFYIMFTFMKHGDSCVTT 308
            .||:....|      |.|..:.||:.:..|:......::.|||        ::..::   ...::
Human   399 PLELSDSEP------VVVYGMDYLQQVSELINRTEPSILNNYL--------IWNLVQ---KTTSS 446

  Fly   309 MRQSMEFASNLLFEERILGRKK--LRSYQNQAGKIFDAIRQQLNIRLERNVLKLPPAEISLLQKK 371
            :.:..|.|...|. |.:.|.||  :..:|.......||                           
Human   447 LDRRFESAQEKLL-ETLYGTKKSCVPRWQTCISNTDDA--------------------------- 483

  Fly   372 LNGLSLSIGNLPGKAGHRRFVTRYYKELEFADDEELATA------HLKVLEHRTR--------AE 422
               |..::|:|..||    ...|..||:......|:.||      .|..::.:||        |.
Human   484 ---LGFALGSLFVKA----TFDRQSKEIAEGMISEIRTAFEEALGQLVWMDEKTRQAAKEKADAI 541

  Fly   423 LSLLDQPNF----KDRRYMLHSYPISNFFFETAYEENGNTIY-VAYDFLADASFDPDSHDIFKVT 482
            ..::..|:|    |:...:...|.||    |.::.:|...:| .:...:||....|.|.|.:.:|
Human   542 YDMIGFPDFILEPKELDDVYDGYEIS----EDSFFQNMLNLYNFSAKVMADQLRKPPSRDQWSMT 602

  Fly   483 P--------------------------------------LGIRFGLEMLKSFDLFNCKHHKVNML 509
            |                                      :|:..|.|:..:||....::.|...|
Human   603 PQTVNAYYLPTKNEIVFPAGILQAPFYARNHPKALNFGGIGVVMGHELTHAFDDQGREYDKEGNL 667

  Fly   510 QLFDDNQITTAGDECVSAWTQDNLLSQRDQYLVVLHLVHEAYFAEGSKFSQRQ 562
            :                .|.|:..|:....:...:...:..|...|.:.:.||
Human   668 R----------------PWWQNESLAAFRNHTACMEEQYNQYQVNGERLNGRQ 704

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Nepl3NP_608904.1 GluZincin 42..581 CDD:301352 124/641 (19%)
ECE2NP_001093590.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 22..64
M13 160..809 CDD:189000 124/641 (19%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165150962
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.840

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