DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl3 and MMEL1

DIOPT Version :9

Sequence 1:	NP_608904.1	Gene:	Nepl3 / 326172	FlyBaseID:	FBgn0031678	Length:	629	Species:	Drosophila melanogaster
Sequence 2:	NP_258428.2	Gene:	MMEL1 / 79258	HGNCID:	14668	Length:	779	Species:	Homo sapiens

Alignment Length:	737	Identity:	151/737 - (20%)
Similarity:	256/737 - (34%)	Gaps:	198/737 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 STVCSANPNLEIMKRMLDDMDEKVEPCHNFYNSS-----------QKNLKWHAFATVSDQFQLLF 72
            |.||:....:....|:|.:||...|||.:||..:           :.|.::..|..:.|:.:::.
Human    86 SEVCTTPGCVIAAARILQNMDPTTEPCDDFYQFACGGWLRRHVIPETNSRYSIFDVLRDELEVIL 150

  Fly    73 DGI-ENEVFEKHSFEEKLQRLYKIC---STMER---PSLLRYFELVKPGEDLNWPFLTPR----- 125
            ..: ||...:.....||.:.||:.|   |.:|:   ..||...|:|.     .||....|
Human   151 KAVLENSTAKDRPAVEKARTLYRSCMNQSVIEKRGSQPLLDILEVVG-----GWPVAMDRWNETV 210

  Fly   126 GGKWPKEK-----------------FQWME--------------ALAR-LRRYGFND-------- 150
            |.:|..|:                 |.|.:              .|.. .|.|.||.
Human   211 GLEWELERQLALMNSQFNRRVLIDLFIWNDDQNSSRHIIYIDQPTLGMPSREYYFNGGSNRKVRE 275

  Fly   151 --IMFGMSIRQDPNSDSGQPIVVFEKKYDSLFRFIESLQNIGLPPKLAKEIAPLDNAIQEMYKSD 213
              :.|.:|:......|:..|       .||.....:.:|.:.|..:|||...|     ||.....
Human   276 AYLQFMVSVATLLREDANLP-------RDSCLVQEDMVQVLELETQLAKATVP-----QEERHDV 328

  Fly   214 MKFEHYARDAAPVKRISLGQLE----IYGVSLTKYLEIVFGR---PFSPDFVVHVENLYYLRGLQ 271
            :...|         |:.|.:|:    :.|.:.|.:::.|...   ...||..|.|..:.||:.|:
Human   329 IALYH---------RMGLEELQSQFGLKGFNWTLFIQTVLSSVKIKLLPDEEVVVYGIPYLQNLE 384

  Fly   272 NLMTAVPSQVVANY------------LTARFS----------FYIMFTFMKHGDSCVTTMRQSME 314
            |::....::.:.||            |:.||.          |..|...::..: ||..:..:||
Human   385 NIIDTYSARTIQNYLVWRLVLDRIGSLSQRFKDTRVNYRKALFGTMVEEVRWRE-CVGYVNSNME 448

  Fly   315 FA-SNLLFEERILGRKK--LRSYQNQAGKIFDAIRQQLNIRLERNVLKLPPAEISLLQKKLNGLS 376
            .| .:|...|...|..|  :|...::...:|.....:|....|.:            :||....:
Human   449 NAVGSLYVREAFPGDSKSMVRELIDKVRTVFVETLDELGWMDEES------------KKKAQEKA 501

  Fly   377 LSIGNLPGKAGH--------RRFVTRYYKELEFADD--EELATAHLKVLEHRTRAELSLLDQPNF 431
            :||..   :.||        .|.:...|..|.|::|  .|.:..:|||...|:..:|.....||.
Human   502 MSIRE---QIGHPDYILEEMNRRLDEEYSNLNFSEDLYFENSLQNLKVGAQRSLRKLREKVDPNL 563

  Fly   432 KDRRYMLHSYPISNFFFETAYEENGNTIYVAYDFLADASFDPDSHDIFKVTPLGIRFGLEMLKSF 496
                :::.:..::.|     |..|.|.|......|....|..:.........:|:..|.|:...|
Human   564 ----WIIGAAVVNAF-----YSPNRNQIVFPAGILQPPFFSKEQPQALNFGGIGMVIGHEITHGF 619

  Fly   497 D-----------------LFNCKHHKVN---MLQLFDDNQITTAGDECVSAWTQ--DNLLSQ--- 536
            |                 .|:.:|.:..   |:..:.:.....|.::.|:.:..  :|:...
Human   620 DDNGRNFDKNGNMMDWWSNFSTQHFREQSECMIYQYGNYSWDLADEQNVNGFNTLGENIADNGGV 684

  Fly   537 RDQYLVVLHLVHEAYFAEGSKFSQRQPNFTTMSLRELFFFRFGQ---SSFGQTLYFGSDFVEGGS 598
            |..|...|     .:.|||.| .|:.|.. .::..:|||..:.|   .|:.......|...:..|
Human   685 RQAYKAYL-----KWMAEGGK-DQQLPGL-DLTHEQLFFINYAQVWCGSYRPEFAIQSIKTDVHS 742

  Fly   599 P-----INSLTRLPVFVRTFNC 615
            |     :.||..|..|..||:|
Human   743 PLKYRVLGSLQNLAAFADTFHC 764

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl3	NP_608904.1	GluZincin	42..581	CDD:301352	133/673 (20%)
MMEL1	NP_258428.2	PepO	102..779	CDD:226118	147/721 (20%)
MMEL1	NP_258428.2	M13	111..777	CDD:189000	143/712 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150990
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740