DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nepl3 and ece1

DIOPT Version :9

Sequence 1:	NP_608904.1	Gene:	Nepl3 / 326172	FlyBaseID:	FBgn0031678	Length:	629	Species:	Drosophila melanogaster
Sequence 2:	NP_001071260.1	Gene:	ece1 / 777750	ZFINID:	ZDB-GENE-061110-100	Length:	752	Species:	Danio rerio

Alignment Length:	699	Identity:	131/699 - (18%)
Similarity:	239/699 - (34%)	Gaps:	223/699 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 VCSANPNLEIMKRMLDDMDEKVEPCHNFYNSS-----QKN------LKWHAFATV-SDQFQLLFD 73
            :|.:.|.:.:...:|..:|..|:||.:|||.:     :||      .:|..|:.: .....::.:
Zfish    80 LCLSEPCVSVASAVLGSLDRSVDPCQDFYNFACGGWMRKNPLPEGKSRWGPFSNLWEHNMAVMKN 144

  Fly    74 GIENEVFEKHS-FEEKLQRLYKICSTMERPSLLRYFELVKPGEDL-----NWPFLTPRGGKWPKE 132
            .:||...:..| .|:|.|..|:.|....:...|.    .||.:||     .|..    .|.|.|:
Zfish   145 LLENTSMKSLSRAEQKAQWYYQACMNESKIEELG----AKPLQDLINQTGGWGL----KGPWEKD 201

  Fly   133 KFQWMEAL----ARLRRYGFNDIMFGMSIRQDPNSDSGQPIVVFEKKYDSLFRFIESLQNIGLPP 193
            .||  |.|    |..|...|    |.:.:..|..|.:...|.|.:             ..:|||.
Zfish   202 NFQ--EVLRIVSANFRTSPF----FTVFVSTDSKSSNSNIIQVDQ-------------SGLGLPS 247

  Fly   194 KLAKEIAPLDNAIQEMYKSDMKFEHYARDAAPVKRIS--LGQLEIYGVSL-------TKYLE--I 247
            :                      |:|....|..|.::  |..|...||.|       .|.:|  |
Zfish   248 R----------------------EYYLNKTANEKYLNAYLNFLVELGVLLGGSQDTSQKMMEEII 290

  Fly   248 VFGRPFSPDFVVHV-----ENLYYLRGLQNLMTAVPSQVVANYLTARFSFYIMFTFMKHGDSCVT 307
            .|....:...|..|     |.:||....:.|.|..|:.....:|::.|:    ...:.:.:..|.
Zfish   291 EFETTLANITVPQVERRDEEKIYYKIQAKELATLAPAIDWMPFLSSVFA----PVELNNSEPVVV 351

  Fly   308 TMRQSMEFASNLLFEERILGRKKLRSYQNQAGKIFDAIRQQLNIRLERNVLKLPPAEISLLQ--- 369
            ..::.::..|.|:..   ..:..|.:|.     |...:|:.::| |::   |...||...|:
Zfish   352 YAKEYLQKVSELISN---TNKSVLNNYM-----IMKVVRKMVSI-LDQ---KFQDAEQRFLEVMY 404

  Fly   370 --KKL-------------NGLSLSIGNLPGKA----GHRRFVTRYYKELEFADDEELATAH---- 411
              ||.             :.|..::|.|..||    ..:.||.....|:::|.::.|.|..
Zfish   405 GTKKSCMPRWKLCVSDTDSALGFALGALFVKATFSEDSKAFVEDMVSEIKWAFEDSLKTVSWMDP 469

  Fly   412 --LKVLEHRTRAELSLLDQPNF----KDRRYMLHSYP-ISNFFFETAYEENGNTIYVAYDFL--- 466
              .|..:.:..|..:::..|.|    |:...:.:.:. :|:.:|:........:..|..|.|
Zfish   470 ETKKAAKEKADAIYNMVGYPKFIMNPKELDKVFNDFDVVSDLYFQNVMNYYNFSARVTADQLRKA 534

  Fly   467 ------------ADASFDPDSHDIFKVTP---------------------LGIRFGLEMLKSFDL 498
                        .:|.::|..:::  |.|                     :|:..|.|:..:||.
Zfish   535 PNRDQWSMTPPTVNAYYNPTKNEM--VLPAGIFQAPFYNHAWPKAMNFGGIGVVMGHELTHAFDD 597

  Fly   499 FNCKHHKVNMLQLFDDNQITTAGDECVSAWTQDN-----------LLSQRDQYLV---------- 542
            ...|:.|       |.|         ::.|.|::           ::.|...|.:
Zfish   598 QGRKYDK-------DGN---------LAKWWQNSSVEAFQHQTQCMVEQYSNYSINNEPLNGKHT 646

  Fly   543 ---------VLHLVHEAYFAEGSKFSQRQPNFTTMSL--RELFFFRFGQ 580
                     .|:..::|| ....|.:..:.:...:.:  .:|||..|.|
Zfish   647 LGENIADNGGLNAAYKAY-VNWIKKNGEEASLPALGMNNHQLFFVGFAQ 694

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl3	NP_608904.1	GluZincin	42..581	CDD:301352	127/678 (19%)
ece1	NP_001071260.1	PepO	94..752	CDD:226118	129/685 (19%)
ece1	NP_001071260.1	M13	101..750	CDD:189000	127/678 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170585565
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.840