DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl3 and mmel1

DIOPT Version :9

Sequence 1:	NP_608904.1	Gene:	Nepl3 / 326172	FlyBaseID:	FBgn0031678	Length:	629	Species:	Drosophila melanogaster
Sequence 2:	XP_017213856.1	Gene:	mmel1 / 560703	ZFINID:	ZDB-GENE-101112-2	Length:	765	Species:	Danio rerio

Alignment Length:	779	Identity:	151/779 - (19%)
Similarity:	256/779 - (32%)	Gaps:	259/779 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 STVCSANPNLEIMKRMLDDMDEKVEPCHNFYNSS----------QKNLKWHA-FATVSDQFQLLF 72
            |.||:....:....|:|.:||..|:||.|||..:          .:....|: |..:.|:.:::.
Zfish    72 SNVCTTPQCVTAAARLLQNMDPSVDPCQNFYQYACGGWIERHVIPETSSLHSVFNILRDELEIVL 136

  Fly    73 DGI---ENEVFEKHSFEEKLQRLYKICST----MERPS--LLRYFELVKPGEDLNWPFLTPRGGK 128
            .|:   ||: .::.:| :|.:.||..|..    .:|.|  |||..:.:               |.
Zfish   137 KGVLEMENK-DDREAF-KKAKTLYSSCMNEILIEQRDSQPLLRLIDSI---------------GD 184

  Fly   129 WPKEKFQW----------MEALARLR-RYGFNDIM----------------------FGMSIRQD 160
            ||.....|          .:.||.|. ||....::                      .||..|..
Zfish   185 WPVASEVWNGTSEQTWSLEDTLAVLNGRYNKKAVLEMFVWPDDRDSSRYIIHVDQPALGMPSRDY 249

  Fly   161 PNSDSGQPIVVFEKKYDSLFRFIESLQNIG----------------------LPPKLAKEIAPLD 203
            ..||..     ::|..::...|:.|:..|.                      |...:|...:|.:
Zfish   250 YLSDGN-----YKKVREAYLEFMVSMARIAREDRNLTQDEERVLEDMSQVLELETDIANATSPAE 309

  Fly   204 --NAIQEMYKSDMKFEHYARDAAPVKRISLGQLEIYGVSLTKYLEIVFGRPFSPDFVVHVEN--- 263
              |.|..:|.     :...|:|...       ..:.|.:.|:|::   |...|....|..:.
Zfish   310 ERNDITVLYN-----KMTLREAQQT-------FNLNGFNWTRYIQ---GIMSSVSISVQSDEPIV 359

  Fly   264 LY---YLRGLQNLMTAVPSQVVANYL------------TARFSFYIMFTFMK--HGDS------- 304
            :|   ||..|..:::....:.:.|||            :.||. .:...:.|  ||.:
Zfish   360 IYCSPYLEKLSEVLSKHSHRTLQNYLVWMLIMDRVSSMSRRFK-DVRAHYRKALHGTTVEEARWR 423

  Fly   305 -CVTTMRQSMEFASNLLF-EERILGRKKLRSYQNQAGKIFDAIRQQLNIRLERNVLKLPPAEISL 367
             ||..::.:||.|...|: .|...|..|     ...|::...|::.....||         |:|.
Zfish   424 DCVRYVQGNMENAVGALYVRETFSGNSK-----RMVGELIKKIQEAYVETLE---------ELSW 474

  Fly   368 LQK----KLNGLSLSIGNLPGKAGH-----RRFVTRYYKELEFADD-------EELATAHLKVLE 416
            :.:    |....:::|....|...|     .:.:.:.|..|.|:::       |.||.:..|  .
Zfish   475 MDEQSKVKAREKAMAISEQIGYPDHILEEENKKLDQEYAHLNFSEENYFENILENLAASAQK--G 537

  Fly   417 HRTRAELSLLDQPNFKDRRYMLHSYPISNFFFETAYEENGNTIYVAYDFLADASFDPDSHDIFKV 481
            |:.      |.:|...| .:::.:..::.|     |..|.|.|......|....|..........
Zfish   538 HKK------LREPVDPD-MWIIGAAVVNAF-----YSHNRNQIVFPAGILQPPFFSEKQLQALNF 590

  Fly   482 TPLGIRFGLEMLKSFD-----------LFN---------------CKHHKVNMLQLFDDNQITTA 520
            ..:|:..|.|:...||           ::|               |      |::.:.......|
Zfish   591 GGIGMVIGHEITHGFDDHGRNFDKDGNMYNWWSNYSAERFEDQSKC------MVEQYGRFSWKLA 649

  Fly   521 GDECVSAWTQ--DNLLSQRDQYLVVLHLVHEAYFA-------EGSKFSQRQPNFTTMSLRELFFF 576
            |.:.||..|.  :|:.....        |.:||.|       ||.:  .|.|.. .|:.::|||.
Zfish   650 GGQNVSGITTLGENIADNGG--------VRQAYKAYVKWVEREGEE--PRLPGL-DMNHKQLFFL 703

  Fly   577 RFGQSSFG--------QTLYFGSDFVEGGSP-----INSLTRLPVFVRTFNCLAPGEQLTTTQK 627
            .|.|...|        ||:.     .:..||     :.||.....|...|:| |.|..:...:|
Zfish   704 NFAQVWCGACRPEYAIQTIK-----TDPHSPLEYRVLGSLQNFEAFSEAFHC-ARGAPMNPEEK 761

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl3	NP_608904.1	GluZincin	42..581	CDD:301352	130/695 (19%)
mmel1	XP_017213856.1	PepO	88..765	CDD:226118	147/763 (19%)
mmel1	XP_017213856.1	M13	95..763	CDD:189000	144/756 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170585595
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.840