Protein Alignment Nepl3 and PHEX

DIOPT Version :10

• Sequence 1: NP_608904.1
• Gene: Nepl3 / 326172
• FlyBaseID: FBgn0031678
• Length: 629
• Species: Drosophila melanogaster
• Sequence 2: NP_000435.3
• Gene: PHEX / 5251
• HGNCID: 8918
• Length: 749
• Species: Homo sapiens
• Alignment Length: 553
• Identity: 95/553 - (17%)
• Similarity: 186/553 - (33%)
• Gaps: 188/553 - (33%)

  Fly    28 LEIMKRMLDDMDEKVEPCHNFY----------NSSQKNL-KWHAFATVSDQFQL-LFDGIENEVF 80
            :|....:|..::..|:||.||:          |...::: .:..:..:.....| |.:.:|..:.
Human    60 IEAAAAILSKVNLSVDPCDNFFRFACDGWISNNPIPEDMPSYGVYPWLRHNVDLKLKELLEKSIS 124

  Fly    81 EKHSFE--EKLQRLYKIC---STMERPS------LLRYFELVKPGEDLNWPFLTPR---GGKWPK 131
            .:...|  :|.:.||..|   ..:|:..      :||:       ....||.|...   .|.|.:
Human   125 RRRDTEAIQKAKILYSSCMNEKAIEKADAKPLLHILRH-------SPFRWPVLESNIGPEGVWSE 182

  Fly   132 EKFQWMEALARLRRYGFNDIMFGMSIRQDPNSDSGQPIVVFE-------------------KKY- 176
            .||..::.||..|....|.:...:.:..|..: |.:.|:..:                   |.|
Human   183 RKFSLLQTLATFRGQYSNSVFIRLYVSPDDKA-SNEHILKLDQATLSLAVREDYLDNSTEAKSYR 246

  Fly   177 DSLFRF-IESLQNIG---------------LPPKLAKEIAPLDNAIQEMYKSDMKFEHYARDAAP 225
            |:|::| :::...:|               |..|:|:.:.|.:|...|...:.|.....   :|.
Human   247 DALYKFMVDTAVLLGANSSRAEHDMKSVLRLEIKIAEIMIPHENRTSEAMYNKMNISEL---SAM 308

  Fly   226 VKRIS-LGQL-EIYGVSLTKYLEIVFGRPFSPDFVVHVENLYYLRGLQNLMTAVPSQVVANY--- 285
            :.:.. ||.: ::....|..:|     :..||...|.|....|.:.|..::.:...:.:|||
Human   309 IPQFDWLGYIKKVIDTRLYPHL-----KDISPSENVVVRVPQYFKDLFRILGSERKKTIANYLVW 368

  Fly   286 ---------LTARFSF-YIMF--------TFMKHGDSCVTTMRQSMEFASNLLFEERILGRKKLR 332
                     |:.||.: ::.|        |.:...|.||..:..::.:.
Human   369 RMVYSRIPNLSRRFQYRWLEFSRVIQGTTTLLPQWDKCVNFIESALPYV---------------- 417

  Fly   333 SYQNQAGKIFDAIRQQLNIRLERNVLKLPPAEISLLQKKLNGLSLSIGNLPGKAGHRRFVTRYYK 397
                 .||:|..:..|.:.:             .::::.:.|:..:            |:....|
Human   418 -----VGKMFVDVYFQEDKK-------------EMMEELVEGVRWA------------FIDMLEK 452

  Fly   398 ELEFADDEELATAHLKVLEHRTRAELSLLDQPNF--------------------------KDRRY 436
            |.|:.|    |....|..| :.||.|:.:..|.|                          :.|:|
Human   453 ENEWMD----AGTKRKAKE-KARAVLAKVGYPEFIMNDTHVNEDLKAIKFSEADYFGNVLQTRKY 512

  Fly   437 MLHSYPISNFFF------ETAYEENGNTIYVAY 463
            :..    |:||:      :|.:..|..|:...|
Human   513 LAQ----SDFFWLRKAVPKTEWFTNPTTVNAFY 541

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl3	NP_608904.1	GluZincin	42..>434	CDD:472708	84/502 (17%)
PHEX	NP_000435.3	M13	74..740	CDD:341056	93/539 (17%)