DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl3 and Nepl20

DIOPT Version :9

Sequence 1:	NP_608904.1	Gene:	Nepl3 / 326172	FlyBaseID:	FBgn0031678	Length:	629	Species:	Drosophila melanogaster
Sequence 2:	NP_651645.1	Gene:	Nepl20 / 43412	FlyBaseID:	FBgn0039613	Length:	700	Species:	Drosophila melanogaster

Alignment Length:	778	Identity:	163/778 - (20%)
Similarity:	276/778 - (35%)	Gaps:	252/778 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 WLLLLLCSTVCSANPNLE--------IMKRMLDD---------MDEKVEPCHNFY-----NSSQK 54
            |:...:.|.:..|.|..|        .||.::..         |::||:||.:||     |..:.
  Fly     9 WIASHVLSVLVLAAPTSEDVLNQDTPYMKELMRQAKAAEIESFMNQKVDPCKDFYAFSCGNYKRI 73

  Fly    55 NLKWHAFATVSDQFQLLFDGIENEVFE-----------------KHSFE-------------EKL 89
            |...:.....:..|:.|..|:..::.:                 ||.:|             |||
  Fly    74 NSALNMRVLTTGVFETLTKGLNRKILKMLNTPHDSHDTPEDIQVKHFYESCLQIKELNSTYSEKL 138

  Fly    90 QRLYKICSTMERPSLLRYFELVKPGEDLNWPFLTPRGGKWPKEKFQWMEALARL-RRYGFNDIMF 153
            :||.....||                    |.|  .|..|.::.|.|:...||: .|||...|:
  Fly   139 KRLIAEFGTM--------------------PLL--EGSSWQEDDFDWLNTTARMAHRYGIMSII- 180

  Fly   154 GMSIRQDPNSDSGQPIVV----FEKKYDSLFR------FIESLQN---------IGLPPKLAKEI 199
            |:.:..|..::....|.:    |..|..|::.      :.::.||         :|:..:||::
  Fly   181 GVGVATDFANNQKNIIYINQQEFPLKTRSMYMDNETAIYRQNYQNNIQLILEKYLGVKDELARK- 244

  Fly   200 APLDNAIQEMYKSDMKFEH---------YARDAAPVKRISLGQL-EIYGVSL--TKYLEIVFGRP 252
                 |.:||::.::...|         ..||.  ::.:::.:| |.|..:|  .:.:.:..|..
  Fly   245 -----AAKEMFEFEVDLAHGLVDNNKHLNLRDL--IELLTVAELRERYAPTLDTDQLIFVSMGEK 302

  Fly   253 FSPDFVVHVENLYYLRGLQNLMTAVPSQVVANYLTARFSFYIMFTFM--------KHGDSCVTTM 309
            .|..  |:..|..|.:.|..::...|...|||||..|    :::.|:        |..::||...
  Fly   303 ISDK--VYEYNRRYQQNLVEVIERTPKSTVANYLFLR----LIWEFIQKPSGVAEKPTEACVDFT 361

  Fly   310 RQSMEFASNLLFEERILGRKKLRSYQNQ-AGKIFDAIRQQLNIRLERNVLKLP------PAEISL 367
            :  ..||.||   :.::.|:    |:|: :.:..|::..||....:..:|..|      |:..||
  Fly   362 K--TYFAKNL---DNMIYRR----YKNEKSSREIDSMWHQLKSTFKETLLSSPALDWIEPSTRSL 417

  Fly   368 LQKKLNGLSLSIGNLPGKAGHRRFVTRYYKELEFADDEELATAHLKVLEHRTRAEL-------SL 425
            ...||..::|.:.|         :|...:.| ||||   |...:...:|:..:.::       .|
  Fly   418 AIAKLEAMTLEVNN---------YVKENFTE-EFAD---LNLQNTDCVENLRQVQMLQAKQMRQL 469

  Fly   426 LDQPNFKDRRYMLHSYPISNFFFETAYEENGNTIYVAYDFLADASFDPDSHDIFKVTPLGIRFGL 490
            ..||........|.||..||...|       |:|.|....|.......|      |.|..:.||.
  Fly   470 YHQPAKPLEAGELLSYTPSNILLE-------NSIKVPVALLQPFYIWSD------VYPNAVMFGT 521

  Fly   491 -------EMLKSFDLFNCK-HHKVNMLQLFDDNQITTAGDECVSAWTQDNLLSQRD-------QY 540
                   |::..||....| ..|.|....:|:.             :..|.|.:||       :|
  Fly   522 LAYLIGHELIHGFDDSGRKFDEKGNSKDWWDEK-------------SSSNFLKRRDCFTKQYGRY 573

  Fly   541 LV-------------------VLHLVHEAYFAEGSKFSQRQ---PN----FTTMSL-------RE 572
            :.                   .:.|.:.||    .|:.:.|   ||    .|..:|       ::
  Fly   574 VYDGIQLKESTAQSENIADNGGMRLAYTAY----RKWYENQLTLPNGAQDMTKETLPNLRYTAKQ 634

  Fly   573 LFFFRFGQSSFG------QTLYFGSDFVEGGS--PINSLTRLPVFVRTFNCLAPGEQLTTTQK 627
            |||..|.||...      :.|...:|....|.  .|.:|:....|.:.|||.| |..:...:|
  Fly   635 LFFISFAQSWCNDVHPKVKALQVSTDDHMPGKFRVIGTLSNFEEFSKEFNCHA-GSAMNPIEK 696

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl3	NP_608904.1	GluZincin	42..581	CDD:301352	140/675 (21%)
Nepl20	NP_651645.1	PepO	50..691	CDD:226118	155/730 (21%)
Nepl20	NP_651645.1	M13	56..697	CDD:189000	154/731 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45454981
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.740