DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl3 and Nepl18

DIOPT Version :9

Sequence 1:	NP_608904.1	Gene:	Nepl3 / 326172	FlyBaseID:	FBgn0031678	Length:	629	Species:	Drosophila melanogaster
Sequence 2:	NP_651643.1	Gene:	Nepl18 / 43410	FlyBaseID:	FBgn0039611	Length:	682	Species:	Drosophila melanogaster

Alignment Length:	748	Identity:	155/748 - (20%)
Similarity:	260/748 - (34%)	Gaps:	214/748 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MMESRSYLSLSWLLLLLCSTVCSANPN-----------------------LEIMKRMLDDMDEKV 42
            ||.||    :.||.||:......|.|:                       :..||.|   |..:|
  Fly     1 MMTSR----VLWLCLLVAIVPAMAKPSDAGDPFADDLTSDYAKKIIVQAKVAEMKTM---MKPEV 58

  Fly    43 EPCHNFYNSSQKNLKWHAF-------ATVSDQFQLLFDGIENEVFE-------KHSFEEKLQRLY 93
            .||.:||..:..|  ||..       ..::|.|:|:..|.:..:..       :...|:|:||.|
  Fly    59 SPCDDFYTHACGN--WHRHNPAQLLGDVMTDNFKLISKGFDRRLQRLLRANDLQSELEKKMQRFY 121

  Fly    94 KICSTMERPSLLRYFELVKPG---EDLNWPFLTPRGGKWPKEKFQWMEALARLR-RYGFNDIMFG 154
            ..|:.:.|..:  :::|....   |....|.|.  |.:|....|.|...:|::: :|| ..|:.|
  Fly   122 MSCNLVHRDDV--HYKLALENVIREYGTLPALV--GAQWNSSDFSWWRTVAQIQHKYG-KQIIIG 181

  Fly   155 MSIRQDPNSDSGQPIVVFEKKYDSLFRFIESL-----------QNIGLPPKLAKEIAPLDNAIQE 208
            :.|..|..:.|...:.:.:..:.::...:.:|           |..||...:||..|      ::
  Fly   182 LEIMHDIRNTSVNRVYISQPDFKTINTRLTNLMEEVRTSMDLQQYFGLSSSVAKHTA------EQ 240

  Fly   209 MYKSDMKFEHYARDAAPVKRISLGQLEIYGV-----------SLTKYLEIVFGRPFSPDFVVHVE 262
            :.:.:..|......||.::.    .|.:|.|           :.|::|.::.|....|      :
  Fly   241 LTELERTFSSGGSGAATLQE----SLSLYTVADLQEKYSDHLNFTEFLGLILGEENIP------K 295

  Fly   263 NLY-----YLRGLQNLMTAVPSQVVANYLTARFSFYIMFTFMKHGD--SCVTTMRQSMEFASNLL 320
            :||     ||......|.:.|....|||:.    :.::..|:....  ..|....:|.:.....|
  Fly   296 SLYIYDEEYLDKALLTMRSTPLATQANYVL----WKLLEDFLVDAQPKDMVKWCTESTKKYFGKL 356

  Fly   321 FEERILGRKKLRSYQNQAGKIFDAIRQQLNIRLERNVLK-LPPAEISLLQKKLNGLSLSIG---- 380
            .|..:..|.:....:::..||:|.|:.....||..:.|. :..|..:|..:||..:.|:|.
  Fly   357 AEHAVYKRYRNPDVESEVHKIWDQIKGIFRQRLLGDKLDWISNATRTLAIEKLERMHLNINSYDE 421

  Fly   381 ----NLPGKAGHRRFVTRYYKELEFADD-EELATAHLKVLEHRTRAELSLLDQP-NFKDRRYMLH 439
                |:.|:.    |:.|    |.:..: ::|..|  |.:....|     ::|| :..|...:|.
  Fly   422 ENFENVYGEV----FIDR----LNYVSNVQQLLIA--KGIRFVAR-----INQPADSVDATELLG 471

  Fly   440 SYPISNFFFETAYEENGNTIYVAYDFLADASFDPDSH-DIFKVTPLGIRFGLEMLKSFDLFNCKH 503
            ..|..|.      :||..||.||  .|....|..|.: :..|...||.....|||..||
  Fly   472 FTPAYNI------QENNITIPVA--LLQPRYFWGDQYPEALKYATLGYLLAHEMLHGFD------ 522

  Fly   504 HKVNMLQLFDDNQITTAGD-----------------ECVSA------WTQDNLLSQRDQYLVV-- 543
                    .|..|...:|:                 :|..|      :....|...:||...:
  Fly   523 --------DDGRQYDASGNLAPWWDLKSRYEFEERRKCFQAQYHEYQYGGSKLPESKDQSENIAD 579

  Fly   544 ---LHLVHEAY---------------FAEGSKFSQRQPNFTTMSLRELFFFRFGQSSFGQTLYFG 590
               |.|.:.||               ..||..|:.||          |||..:.|.......:..
  Fly   580 SGGLKLAYAAYELWLGQQSEEVLQRETMEGLPFNSRQ----------LFFLGYAQLLCDDVQFLF 634

  Fly   591 SDFV---EGGSP-----INSLTRLPVFVRTFNC 615
            ..:|   :..:|     |..|:....|...|||
  Fly   635 QPWVSQSDRHAPSKYRVIGPLSNFQEFPWVFNC 667

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl3	NP_608904.1	GluZincin	42..581	CDD:301352	132/640 (21%)
Nepl18	NP_651643.1	PepO	54..682	CDD:226118	142/688 (21%)
Nepl18	NP_651643.1	M13	58..679	CDD:189000	141/684 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45454982
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.740