DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl3 and MME

DIOPT Version :9

Sequence 1:	NP_608904.1	Gene:	Nepl3 / 326172	FlyBaseID:	FBgn0031678	Length:	629	Species:	Drosophila melanogaster
Sequence 2:	NP_000893.2	Gene:	MME / 4311	HGNCID:	7154	Length:	750	Species:	Homo sapiens

Alignment Length:	720	Identity:	136/720 - (18%)
Similarity:	240/720 - (33%)	Gaps:	224/720 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LSLSWLLLLLC--------------STVCSANPNLEIMKRMLDDMDEKVEPCHNFYNSSQKN-LK 57
            :|||.|:|||.              ..:|.::..::...|::.:||...|||.:|:..:... ||
Human    29 ISLSVLVLLLTIIAVTMIALYATYDDGICKSSDCIKSAARLIQNMDATTEPCTDFFKYACGGWLK 93

  Fly    58 WHAFATVSDQ---FQLLFDGIE---NEVFEKHSFE-----EKLQRLYKIC---STMERPSLLRYF 108
            .:.....|.:   |.:|.|.:|   .:|.::...|     :|.:.||:.|   |.::.
Human    94 RNVIPETSSRYGNFDILRDELEVVLKDVLQEPKTEDIVAVQKAKALYRSCINESAIDS------- 151

  Fly   109 ELVKPGEDL--------NWPFLTPR-----GGKWPKEKFQWMEALARLR-RYGFNDIMFGMSIRQ 159
               :.||.|        .||..|..     |..|..||     |:|:|. :|| ..::..:.:..
Human   152 ---RGGEPLLKLLPDIYGWPVATENWEQKYGASWTAEK-----AIAQLNSKYG-KKVLINLFVGT 207

  Fly   160 D------------------PNSDSGQPIVVFEKKYDSLFRFIESL-----QNIGLP---PKLAKE 198
            |                  |:.|..:...::::...:...|:.|:     |...||   .:||.|
Human   208 DDKNSVNHVIHIDQPRLGLPSRDYYECTGIYKEACTAYVDFMISVARLIRQEERLPIDENQLALE 272

  Fly   199 IAPLDNAIQEMYKSDMKFEHYARDAAPVKRISLGQ------LEIYG-----------------VS 240
            :..:....:|:..:..|.|..........:::|.|      |||.|                 :|
Human   273 MNKVMELEKEIANATAKPEDRNDPMLLYNKMTLAQIQNNFSLEINGKPFSWLNFTNEIMSTVNIS 337

  Fly   241 LTKYLEIVFGRPFSPDFVVHVENL---YYLRGLQNLMT-----AVPSQVVANYLTARFSF----Y 293
            :|...::|.   ::|:::..::.:   |..|.|||||:     .:.|.:...|..:|.:|    |
Human   338 ITNEEDVVV---YAPEYLTKLKPILTKYSARDLQNLMSWRFIMDLVSSLSRTYKESRNAFRKALY 399

  Fly   294 IMFTFMKHGDSCVTTMRQSMEFASNLLFEERILGRKKLRSYQNQAGKIFDAIRQQLN-------- 350
            ...:.......|...:..:||.|...|:.|.....:.....::...:|.:...|.|:
Human   400 GTTSETATWRRCANYVNGNMENAVGRLYVEAAFAGESKHVVEDLIAQIREVFIQTLDDLTWMDAE 464

  Fly   351 --IRLERNVLKLP-----PAEISLLQKKLNGLSLSIGNLPGKAGHRRFVTRYYKELEFADDE--E 406
              .|.|...|.:.     |.:|.....|||                    ..|.||.:.:||  |
Human   465 TKKRAEEKALAIKERIGYPDDIVSNDNKLN--------------------NEYLELNYKEDEYFE 509

  Fly   407 LATAHLKVLEHRTRAELSLLDQPNFKDRRYMLHSYPISNFFFETAYEENGNTIYVAYDFLADASF 471
            ....:||..:.:   :|..|.:...||.  .:....:.|.|    |....|.|......|....|
Human   510 NIIQNLKFSQSK---QLKKLREKVDKDE--WISGAAVVNAF----YSSGRNQIVFPAGILQPPFF 565

  Fly   472 DPDSHDIFKVTPLGIRFGLEMLKSFDLFNCKHHKVNMLQLFDDNQITTAGDECVSAWTQDNLLSQ 536
            .....:......:|:..|.|:...||               |:.:......:.|..|||
Human   566 SAQQSNSLNYGGIGMVIGHEITHGFD---------------DNGRNFNKDGDLVDWWTQ------ 609

  Fly   537 RDQYLVVLHLVHEAYFAEGSKFSQRQPNFTTMSLRELFFFRFGQSSFGQTLYFGSDFVEGGSPIN 601
                                   |...||...|  :...:::|..|:.         :.||..:|
Human   610 -----------------------QSASNFKEQS--QCMVYQYGNFSWD---------LAGGQHLN 640

  Fly   602 SLTRL 606
            .:..|
Human   641 GINTL 645

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl3	NP_608904.1	GluZincin	42..581	CDD:301352	120/645 (19%)
MME	NP_000893.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..20
		Stop-transfer sequence. /evidence=ECO:0000255	16..23
		M13	79..748	CDD:189000	124/670 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150929
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740