DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl3 and Nep4

DIOPT Version :9

Sequence 1:	NP_608904.1	Gene:	Nepl3 / 326172	FlyBaseID:	FBgn0031678	Length:	629	Species:	Drosophila melanogaster
Sequence 2:	NP_650904.3	Gene:	Nep4 / 42449	FlyBaseID:	FBgn0038818	Length:	1040	Species:	Drosophila melanogaster

Alignment Length:	844	Identity:	166/844 - (19%)
Similarity:	265/844 - (31%)	Gaps:	343/844 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 MKRMLDDMDEKVEPCHNFYNSSQKNLKWHAFATVS------DQFQLLFDGIE---NEVFEK---- 82
            |||.   ||.||:||.:||..:..|  |.....:.      |.|::|.:.::   ..:.||
  Fly   266 MKRY---MDNKVDPCVDFYKYACGN--WERLHPIPKDKAGFDTFEMLRESLDLVLRNLLEKNTPV 325

  Fly    83 HSFEEKLQR------LYKICS--------------TMER-------------PSLLRY------- 107
            ||..| |::      |:|:..              |.||             ..|:||
  Fly   326 HSAAE-LRKSPVRNTLFKLNEQGEGEGEADQAAELTAERLRRHIVSKRQLLNRVLVRYKRYTNGT 389

  Fly   108 ------------------------------------------FELVKPGED------------LN 118
                                                      .:.:||.:|            :|
  Fly   390 KRKRLIETPRERTKEEEAAPPVVLPKDKTKDKSDNEEQLHVPTDFLKPHQDAQLKAKNLYRSCVN 454

  Fly   119 WPFLTPRG-----------GKWP-------KEKFQWMEALARLRRYGFNDIMF----GMSIRQDP 161
            ...|..||           |.||       :..|.|....|.||||. |||:.    |..|:
  Fly   455 SAVLAKRGLEPLHTLIRELGGWPVLESQWSESNFNWQVLAATLRRYN-NDILIVQWVGADIK--- 515

  Fly   162 NSDSGQPIVVFEKKYDSLFRFIESLQNIGLP-------PKLAKEIAPLDNAIQEMY------KSD 213
              :|.:.||.|::            ..:|||       |..||.:......:.|:.      |:|
  Fly   516 --NSEENIVQFDQ------------TGLGLPTREYFLQPSNAKYLQAYQRYMAEVMHKMGASKAD 566

  Fly   214 --------MKFE-HYARDAAPV----------KRISLGQLE--IYGVSLTKYLEIVFGRPFSPDF 257
                    :.|| ..|...||.          ||::|.||:  :..:....||:.:..|......
  Fly   567 AQRVASELVAFETQLAGITAPAEQRLNVTKLYKRMTLDQLQAVVPEIKWRAYLQSLQDREVLGTE 631

  Fly   258 VVHVENLYYLRGLQNLMTAVPSQVVANYLTARF-----------------SFYIMFTFMKHGDS- 304
            .|.:..:.|:..|..|:.....:.|:||:..||                 |||......:....
  Fly   632 EVVIYAVEYMSKLVTLLDETDPRTVSNYMMWRFVRHRINNVDDRFDDIKQSFYHALFGREESPQR 696

  Fly   305 ---CVTTMRQSMEFASNLLFEERILGRKKLRSYQNQAGKIFDAIRQQLNIRLE-RNVLK----LP 361
               |:..:..:|..|...:|..|.......|          |.:|...:::.. |::||    |.
  Fly   697 WKVCIAQVNTNMGMAVGSMFVSRYFDNNSKR----------DTLRMTHDLQQAFRDILKTTDWLD 751

  Fly   362 PAEISLLQKKLNGLSLSIG---------NLPGK-AGHRRFVTRYYKELEFADDEELATAHLKVLE 416
            .....|.::|:|.:||.||         .|..| ||...:..:|::..            |.||.
  Fly   752 DTTKQLAEEKVNAMSLKIGYPDFILNPSELNSKYAGIEIYPEKYFENT------------LNVLL 804

  Fly   417 HRTRAELSLL----DQPNFKDRRYMLHSYPISNFFFETAYEENGNTIYVAYDFLADASFDPDSHD 477
            |..:.|.:.|    ::.|::....::::|          |..|.|.|.    |.|.....|..|.
  Fly   805 HTAKTEQAKLHERVNKTNWQTAPAIVNAY----------YSRNKNQIM----FPAGILQPPFYHR 855

  Fly   478 IFKVT----PLGIRFGLEMLKSFDLFNCKHHKVNMLQLFDDNQITTAGDECVSAWTQDN------ 532
            .|..:    .:|:..|.|:...||         :..:|||.|     |:  :..|..|:
  Fly   856 HFPKSLNFGGIGVVIGHELTHGFD---------DKGRLFDRN-----GN--IHKWWTDSSIRGFD 904

  Fly   533 -----LLSQRDQYLVV---------------------LHLVHEAYFAEGSKFSQRQPNFTT---- 567
                 :::|...|.|.                     |.....||    .::.:..|:..:
  Fly   905 ERARCIIAQYSNYTVEEVGIVLNGESTQGENIADNGGLRQAFHAY----QRWLKEHPSEVSDEIL 965

  Fly   568 ----MSLRELFFFRFGQ------------SSFGQTLYFGSDFVEGGSPINSLTRLPVFVRTFNC 615
                |:..:|||..|||            :.....::....|...|:..||:.    |.|.|||
  Fly   966 PGLNMTGPQLFFLNFGQVWCGAMRPEAIRNKLNTAIHSPGRFRVIGTLSNSVD----FAREFNC 1025

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl3	NP_608904.1	GluZincin	42..581	CDD:301352	151/797 (19%)
Nep4	NP_650904.3	M13	274..1038	CDD:189000	160/833 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45450791
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.740