Protein Alignment Nepl3 and Nep2

DIOPT Version :10

• Sequence 1: NP_608904.1
• Gene: Nepl3 / 326172
• FlyBaseID: FBgn0031678
• Length: 629
• Species: Drosophila melanogaster
• Sequence 2: NP_001246914.1
• Gene: Nep2 / 40588
• FlyBaseID: FBgn0027570
• Length: 774
• Species: Drosophila melanogaster
• Alignment Length: 613
• Identity: 130/613 - (21%)
• Similarity: 219/613 - (35%)
• Gaps: 148/613 - (24%)

  Fly    21 VCSANPNLEIMKRMLDDMDEKVEPCHNFY-----------NSSQKNLKWHAFATVSDQFQLLFDG 74
            ||.....:.....:|..|..:||||.|||           |.....:....|:.:||:.|.....
  Fly    83 VCLTQECIHTASTVLRKMKPEVEPCDNFYEFACGTYLEEENIPDDKVSISTFSVISDKLQEQLKD 147

  Fly    75 I----ENEVFEKHSFEEKLQRLYKICSTMERPSLLRYFELVKPGEDL-NWPFLTPRGGKW-PKEK 133
            |    ..|...||.....|  |||.|........|....:.:..|.| .||.:  :|..| ..:.
  Fly   148 IITAERPETEPKHFRLPNL--LYKACMNKTLIETLGPEPITRVAERLGGWPLI--KGDSWNADDS 208

  Fly   134 FQWMEALARLRRYGFN-DIMFGMSIRQD-PNS-----DSGQPIVVFEKKYDSLFR-FIESLQNIG 190
            :.|.|.:.:.|..||: |.:...||..| .||     |..|..:...::|  |.: |.|:|  :.
  Fly   209 WTWQEQVKKFRTAGFSMDYIIDFSIGVDLQNSTKRLIDLDQSSLALSREY--LVKGFNETL--VT 269

  Fly   191 LPPKLAKEIAPLDNAIQEMYKSD----MKFEHYARDAAPVKRISLGQLEIYGVSLTKYLEIVF-- 249
            ...|...:||.|..|.:::.|::    ::||....:.:..........|:|.:.....|:..:
  Fly   270 AYYKYMVDIAVLFGANRDLAKTELLLSLEFEMALANISWPNEKRRNSSELYNLRTPAQLQAAYPY 334

  Fly   250 -------------GRPFSPDFVVHVENLYYLRGLQNLMTAVPSQVVANYLTARFSFYIMFTFMKH 301
                         |...:.|.::::....:...|..|:...|.:|:|||:..|.          |
  Fly   335 VQWVDYMNALLPEGLNVAEDEMINLSVPSFFEDLGKLLAKTPKRVIANYMFWRI----------H 389

  Fly   302 GDSCVTTMRQSMEFASNLLFEERILGRKKLRSYQNQAGKIFDAIRQQLNIRLERNVLKLPPAEIS 366
            |            |:...|.||   .||:...|......     ||:...|.:..|.....:...
  Fly   390 G------------FSVGFLSEE---FRKRQLQYATALSG-----RQEQEARWKECVDIATSSMDE 434

  Fly   367 LLQKKLNGLSLSIGNL-PGKAGHRRFVTRYYKELEFADDEELATAHLKVLEHRTRAELSLLDQPN 430
            :.:...:.|.:|:|:| .||..|:   ......||..:  |:......:|:     |::.:|...
  Fly   435 VCEDDFDSLGISVGSLYVGKHFHK---DSKANALEMVN--EIRNVFNDILD-----EVNWMDAKT 489

  Fly   431 FKDRRYMLHS------YPISNFFFETAYEENGNTIYVAYDFLADASFDPDSH-DIFKVTPLGIR- 487
            .|:.:..|||      ||         .|...|....||  .|....|||.: :.|    ||:.
  Fly   490 KKEAKLKLHSMATHIGYP---------DEMLDNEKLAAY--YAKLDIDPDKYFESF----LGMNI 539

  Fly   488 FGLEMLKSFDLFNCKHHKVNMLQLFDDNQITTAGDECVSAW--TQDNLL-------------SQR 537
            ||.:.  ||:......:|.:.        :..|....|:|:  :.:|.:             :||
  Fly   540 FGTDY--SFNKLRLPVNKTDW--------VRHARPAIVNAFYSSLENSIQFPAGILQGHFFNAQR 594

  Fly   538 DQYL-------VVLHLVHEAYFAEGSKF 558
            .:|:       |:.|.:...:..:|.:|
  Fly   595 PKYMNFGAIGYVIGHEITHGFDDQGRQF 622

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl3	NP_608904.1	GluZincin	42..>434	CDD:472708	94/436 (22%)
Nep2	NP_001246914.1	M13	104..772	CDD:341056	126/592 (21%)