Protein Alignment Nepl3 and KEL

DIOPT Version :10

• Sequence 1: NP_608904.1
• Gene: Nepl3 / 326172
• FlyBaseID: FBgn0031678
• Length: 629
• Species: Drosophila melanogaster
• Sequence 2: XP_005250050.1
• Gene: KEL / 3792
• HGNCID: 6308
• Length: 744
• Species: Homo sapiens
• Alignment Length: 760
• Identity: 144/760 - (18%)
• Similarity: 246/760 - (32%)
• Gaps: 235/760 - (30%)

  Fly    15 LLLCSTV-------------CSANPNLEIMKRMLDDMDEKVEPCHNFYN-----SSQKNLKWHAF 61
            ||||.:|             |..:..|::....|...:..|.||.:|::     :.:.|..:...
Human    69 LLLCFSVLLFYNFQNCGPRPCETSVCLDLRDHYLASGNTSVAPCTDFFSFACGRAKETNNSFQEL 133

  Fly    62 ATVS-DQFQLLFDGIENEVFEKHSFEEKLQRLYKICSTMERPSLLRYFELVKPG------EDL-N 118
            ||.: ::.:.:.: ::|. :...|.|||..:.|..|  |:..::    |....|      |:| .
Human   134 ATKNKNRLRRILE-VQNS-WHPGSGEEKAFQFYNSC--MDTLAI----EAAGTGPLRQVIEELGG 190

  Fly   119 WPFLTPRGGKWPKEKFQWMEALARLRRYG----------------------FNDIMFGMSIRQDP 161
            |..    .|||....|.....|. :.:||                      .:...|.:.::||.
Human   191 WRI----SGKWTSLNFNRTLRLL-MSQYGHFPFFRAYLGPHPASPHTPVIQIDQPEFDVPLKQDQ 250

  Fly   162 NSDSGQPIVVFEKKYDSLFR-FIESLQNIGL----PPKLAKEIAPLDNAI-QEMYKSDMKFEHYA 220
            .          :|.|..:|| ::..|..:|.    .|...:|.:.|..:| ..:::.....|...
Human   251 E----------QKIYAQIFREYLTYLNQLGTLLGGDPSKVQEHSSLSISITSRLFQFLRPLEQRR 305

  Fly   221 RDAAPVKRISLGQLE--IYGVSLTKYLEIVF-GRPFSPDFVVHVENLYYLRGLQNLMTAVPSQVV 282
            ......:.:::.||:  ...:.....|:..| ....||...:.|.::.||:.:        ||:|
Human   306 AQGKLFQMVTIDQLKEMAPAIDWLSCLQATFTPMSLSPSQSLVVHDVEYLKNM--------SQLV 362

  Fly   283 ANYLTARFSFY-------IMFTFMKHGDS------------------------------CVTTMR 310
            ...|..:..|.       ::.|.....||                              ||....
Human   363 EEMLLKQRDFLQSHMILGLVVTLSPALDSQFQEARRKLSQKLRELTEQPPMPARPRWMKCVEETG 427

  Fly   311 QSMEFASNLLFEERILGRKKLRSYQNQAGKIFDAIRQQLNIRLERNVLKLPPAEISLLQKKLNGL 375
            ...|.....||.....|    .|.::.|.|:|.|||..|..|| ||:..:.....::.|.|:..|
Human   428 TFFEPTLAALFVREAFG----PSTRSAAMKLFTAIRDALITRL-RNLPWMNEETQNMAQDKVAQL 487

  Fly   376 SLSIGNLPGKAGHRRFVTRYYKELEFA----DDEELATAHLK-----VLEHRTRAELSLLDQPNF 431
            .:.:|           .:.:..:.|.|    :|.:|.::.|:     |...|.|...|.| ||
Human   488 QVEMG-----------ASEWALKPELARQEYNDIQLGSSFLQSVLSCVRSLRARIVQSFL-QP-- 538

  Fly   432 KDRRYMLHSYPISNFFFETAYEENGNTIYVAYDFLADASFDPDSHDIFKVTPLGIRFGL------ 490
                :..|.:.:|.:.....|..:.:.:......|....|.|.       .|..:.||.
Human   539 ----HPQHRWKVSPWDVNAYYSVSDHVVVFPAGLLQPPFFHPG-------YPRAVNFGAAGSIMA 592

  Fly   491 -EMLKSF-------DLFNCKHHKVNMLQLFDDNQITTAGDECV----SAWTQDNLLSQRDQYLVV 543
             |:|..|       ....|.:|.:....|            |:    :|:...:..|..|....:
Human   593 HELLHIFYQLLLPGGCLACDNHALQEAHL------------CLKRHYAAFPLPSRTSFNDSLTFL 645

  Fly   544 --------LHLVHEAYFAEGSKFSQRQPNFTTMSLREL----FFFRFGQSSFGQTLYFGSDFVEG 596
                    |.:..:||    ||...|....|.:...:|    .|||    |:.|.:      ...
Human   646 ENAADVGGLAIALQAY----SKRLLRHHGETVLPSLDLSPQQIFFR----SYAQVM------CRK 696

  Fly   597 GSPINS--------------LTRLPVFVRTFNCLAPGEQLTTTQK 627
            .||.:|              |:..|.|.|.|.| |.|..|..:.:
Human   697 PSPQDSHDTHSPPHLRVHGPLSSTPAFARYFRC-ARGALLNPSSR 740

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl3	NP_608904.1	GluZincin	42..>434	CDD:472708	92/481 (19%)
KEL	XP_005250050.1	M13	109..742	CDD:341056	136/720 (19%)