Protein Alignment Nepl3 and Nepl4

DIOPT Version :10

• Sequence 1: NP_608904.1
• Gene: Nepl3 / 326172
• FlyBaseID: FBgn0031678
• Length: 629
• Species: Drosophila melanogaster
• Sequence 2: NP_609019.1
• Gene: Nepl4 / 33889
• FlyBaseID: FBgn0031805
• Length: 652
• Species: Drosophila melanogaster
• Alignment Length: 705
• Identity: 142/705 - (20%)
• Similarity: 257/705 - (36%)
• Gaps: 174/705 - (24%)

  Fly    12 WLLLLLCSTV----------------------CSANPNLEIMKRMLDDMDEKVEPCHNFYNSSQK 54
            |..|||..:.                      |::..|.:.:..::..:|.:..||.:||  :..
  Fly     6 WTALLLLGSATCGSSVPVKANDPEQSCPYLGECNSTINQQHIDTLMSYVDSEKNPCEDFY--AYA 68

  Fly    55 NLKW------HAFATVSDQFQL--LFDGIENEVFEKHSFEE-------KLQRLYKICSTMERPSL 104
            ..||      |..||:..:.|:  .::.:..::....|..|       |:...|:.|..:|:|.|
  Fly    69 CGKWRAKHGSHTTATMISESQINRQYEDLFLQLLRNPSAPEYGYPMFAKVLAHYQSCIALEKPDL 133

  Fly   105 LRYFELVKPG--EDLNWPFLTPRGGKWPKEKFQWMEALARLRRYGF---------------NDIM 152
            .||.||:...  ..||              ...||..||.|.|||:               :.::
  Fly   134 RRYIELLDRDLLASLN--------------STHWMHLLAALGRYGYHGHYVQVEVRWYNATHHMI 184

  Fly   153 FGMSIRQDPNSDSGQPIVVFEKKYDSLFRFIESLQNIGLPP--KLAKEIAPLDNAIQEMYK---S 212
            |.:...:..|....|.|      ||:|     |......||  :|.::...|:..:..:.|   :
  Fly   185 FLLPHNRHLNLSLTQDI------YDAL-----SQDGSSWPPLHQLQEQFRSLEQNLVRLAKPHSA 238

  Fly   213 DMKFEHYARDAAPVKRISLGQLEIYGVSLTKYLEIVFGRPFSPDFVVHVENLYYLRGLQNLMTAV 277
            |..|.:|:.|..        :.|:.|:...:.|....||....:.|..|::|..:.||...:..|
  Fly   239 DDTFRNYSLDQI--------RTEVPGLHWDEALRTQLGRSVPGNHVFQVDDLDAIEGLVEYLNTV 295

  Fly   278 PSQVVANYLTARFSFYIMFTFMKH-------------GDSCVTTMRQSMEFASNLLFEERILGRK 329
            .:.::..|..|||..:::  .:.|             |.:|:..||:|:....|.::|.....|:
  Fly   296 DTLLLNRYSLARFLSHLL--ELPHNPLATWESGQRSRGRNCIRHMRRSVYLPMNYVYERSFYSRR 358

  Fly   330 KLRSYQNQAGKIFDAIRQQLNIRLERNVLKLPPAEISLLQKKLNGLSLSIGNLPGKA-------- 386
            : .:.:.....:|..::.||.:|::.|...|....:..||.|::.:.:::||||...
  Fly   359 R-HADELVIHSVFQQLQSQLELRVQHNAFNLSQDLVKSLQAKVHQMRINVGNLPPNVTEQFYWDS 422

  Fly   387 ------------GHRRFVTRYY---KELEFADDEELATAHLKVLEHRTRAELSLLDQPNFKDRRY 436
                        .|...:..||   .:||.:.|:|..........|          .|.|.|.
  Fly   423 DRRWSVGRDFYENHLNSLLYYYTLVADLESSSDQEERDIWYSFNMH----------TPEFPDN-- 475

  Fly   437 MLHSYPISNFFFETAYEENGNTIYVAYDFLADASFDPDSHDIFKVTPLGIRFGLEMLKSFDLFNC 501
             :.:.|   :|:..     ||.|:|.|.::....||.:.........|....|.|::.:||....
  Fly   476 -IDATP---YFYCL-----GNIIFVPYSYVKRPFFDANFWPALLYGDLANTLGHEIMHAFDTDLV 531

  Fly   502 KHHKVNMLQLFDDN----QITTAGDECVSAWTQDNLLSQRDQYLVVLHLVHEAYFAEGSKFSQRQ 562
            .:.....|:.|.|.    ::......|::  :...:|::|...:....|..:.|   |..:..|.
  Fly   532 DYDAQGNLRNFSDQLGEVELYNGAVGCLN--SSAVMLNERTSDVSGSRLAMQTY---GGDWLTRS 591

  Fly   563 PNFTTMSLRELFFFRFGQSSFGQTLYFGSDFVEGGSP-IN-SLTRLPVFVRTFNC 615
            .|      ..|:|.:|.....|..   |..:.:.||. :| :|.::|.|...|.|
  Fly   592 GN------GRLYFLQFAHFFCGDE---GDQYHDSGSQRLNYALGQVPQFAEVFRC 637

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl3	NP_608904.1	GluZincin	42..>434	CDD:472708	96/464 (21%)
Nepl4	NP_609019.1	GluZincin	59..649	CDD:472708	135/652 (21%)