DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl3 and Mmel1

DIOPT Version :9

Sequence 1:	NP_608904.1	Gene:	Nepl3 / 326172	FlyBaseID:	FBgn0031678	Length:	629	Species:	Drosophila melanogaster
Sequence 2:	NP_038811.2	Gene:	Mmel1 / 27390	MGIID:	1351603	Length:	766	Species:	Mus musculus

Alignment Length:	726	Identity:	144/726 - (19%)
Similarity:	260/726 - (35%)	Gaps:	172/726 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 LCSTVCSANPNLEIMKRMLDDMDEKVEPCHNFYNSS-----------QKNLKWHAFATVSDQFQL 70
            |.|.:|:....:....|:|::||:...||.|||..:           :.|.::..|..:.|:.::
Mouse    71 LKSDICTTPSCVIAAARILENMDQSRNPCENFYQYACGGWLRHHVIPETNSRYSVFDILRDELEV 135

  Fly    71 LFDGI-ENEVFEKHSFEEKLQRLYKIC---STMER---PSLLRYFELVKPGEDLNWPFLTPR--- 125
            :..|: |:...:.....||.:.||:.|   |.:|:   ..||...::|.     .||....:
Mouse   136 ILKGVLEDSTSQHRPAVEKAKTLYRSCMNQSVIEKRDSEPLLSVLKMVG-----GWPVAMDKWNE 195

  Fly   126 --GGKWPKEKFQWMEALARLRRYGFNDIMFGMSIRQDPNSDSGQPIVV-------------FEKK 175
              |.||..|:     .||.|.......::..:.|..|..:.|...|.:             |::.
Mouse   196 TMGLKWELER-----QLAVLNSQFNRRVLIDLFIWNDDQNSSRHVIYIDQPTLGMPSREYYFQED 255

  Fly   176 YDSLFR--FIESLQNIGL----PPKLAKEIAPLDNAIQEMYKSDMKFEHYARDAAPVK------- 227
            .:...|  ::|.:.::..    ...|:||.|.:...:.|:.:.:   .|.|....|.:
Mouse   256 NNHKVRKAYLEFMTSVATMLRKDQNLSKESAMVREEMAEVLELE---THLANATVPQEKRHDVTA 317

  Fly   228 ---RISLGQLE----IYGVSLTKYLEIVFGR---PFSPDFVVHVENLYYLRGLQNLMTAVPSQVV 282
               |:.|.:|:    :.|.:.|.:::.|...   ...||..|.|..:.||..|::::.:..::.:
Mouse   318 LYHRMDLMELQERFGLKGFNWTLFIQNVLSSVEVELFPDEEVVVYGIPYLENLEDIIDSYSARTM 382

  Fly   283 ANYLTARF-------------SFYIMFTFMKHGDS--------CVTTMRQSMEFASNLLFEERIL 326
            .|||..|.             ...:.:....:|.:        ||:.:..:||.|...|:.:|..
Mouse   383 QNYLVWRLVLDRIGSLSQRFKEARVDYRKALYGTTVEEVRWRECVSYVNSNMESAVGSLYIKRAF 447

  Fly   327 GR----------KKLRSYQNQAGKIFDAIRQQLNIRLERNVLKLPPAEISLLQKKLNGLSLSIGN 381
            .:          :|:||       :|.....:||...|.:..|        .|:|...:...||
Mouse   448 SKDSKSTVRELIEKIRS-------VFVDNLDELNWMDEESKKK--------AQEKAMNIREQIG- 496

  Fly   382 LPG--KAGHRRFVTRYYKELEFADD--EELATAHLKVLEHRTRAELSLLDQPNFKDRRYMLHSYP 442
            .|.  ...:.:.:...|..|.|.:|  .|....:||     ..|:.||.......|:...:....
Mouse   497 YPDYILEDNNKHLDEEYSSLTFYEDLYFENGLQNLK-----NNAQRSLKKLREKVDQNLWIIGAA 556

  Fly   443 ISNFFFETAYEENGNTIYVAYDFLADASFDPDSHDIFKVTPLGIRFGLEMLKSFD---------- 497
            :.|.|    |..|.|.|......|....|..|.........:|:..|.|:...||
Mouse   557 VVNAF----YSPNRNQIVFPAGILQPPFFSKDQPQSLNFGGIGMVIGHEITHGFDDNGRNFDKNG 617

  Fly   498 -------LFNCKHHKVN---MLQLFDDNQITTAGDECVSAWTQ--DNLLSQ---RDQYLVVLHLV 547
                   .|:.:|.:..   |:..:.:.....|.::.|:.::.  :|:...   |..|...|.
Mouse   618 NMLDWWSNFSARHFQQQSQCMIYQYGNFSWELADNQNVNGFSTLGENIADNGGVRQAYKAYLR-- 680

  Fly   548 HEAYFAEGSKFSQRQPNFTTMSLRELFFFRFGQ---SSFGQTLYFGSDFVEGGSP-----INSLT 604
               :.|:|.| .||.|.. .::..:|||..:.|   .|:.......|...:..||     :.||.
Mouse   681 ---WLADGGK-DQRLPGL-NLTYAQLFFINYAQVWCGSYRPEFAVQSIKTDVHSPLKYRVLGSLQ 740

  Fly   605 RLPVFVRTFNC 615
            .||.|...|:|
Mouse   741 NLPGFSEAFHC 751

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl3	NP_608904.1	GluZincin	42..581	CDD:301352	126/660 (19%)
Mmel1	NP_038811.2	PepO	89..766	CDD:226118	140/708 (20%)
Mmel1	NP_038811.2	M13	97..764	CDD:189000	137/700 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167841106
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840