DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nepl3 and Phex

DIOPT Version :9

Sequence 1:	NP_608904.1	Gene:	Nepl3 / 326172	FlyBaseID:	FBgn0031678	Length:	629	Species:	Drosophila melanogaster
Sequence 2:	NP_037136.2	Gene:	Phex / 25512	RGDID:	3323	Length:	749	Species:	Rattus norvegicus

Alignment Length:	582	Identity:	102/582 - (17%)
Similarity:	197/582 - (33%)	Gaps:	197/582 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LSLSWLLLLLCSTV---------CSANPNLEIMKRMLDDMDEKVEPCHNFY----------NSSQ 53
            |.|..||.|:...:         |.....:|....::..::..|:||.||:          |...
  Rat    31 LVLGTLLFLVSQGLLSFQAKQEYCLKPECIEAAAAIMSKVNLSVDPCENFFRFACDGWISNNPIP 95

  Fly    54 KNL-KWHAFATVSDQFQLLFDG-IENEVFEKHSFE--EKLQRLYKIC---STMERPS------LL 105
            ::: .:..:..:.....|.... :|..|..:...|  :|.:.||..|   ..:|:..      :|
  Rat    96 EDMPSYGVYPWLRHNVDLKLKALLEKSVSRRRDTEAVQKAKILYSSCMNEKAIEKADAKPLLHIL 160

  Fly   106 RYFELVKPGEDLNWPFLTPR---GGKWPKEKFQWMEALARLRRYGFNDIMFGMSIRQDPNSDSGQ 167
            |:       ....||.|...   .|.|.:.||..::.||..|....|.:...:.:..|..: |.:
  Rat   161 RH-------SPFRWPVLEANIGPEGVWSERKFSLLQTLATFRGQYSNSVFIRLYVSPDDKA-SNE 217

  Fly   168 PIVVFE-------------------KKY-DSLFRF-IESLQNIG---------------LPPKLA 196
            .|:..:                   |.| |:|::| :::...:|               |..|:|
  Rat   218 HILKLDQATLSLAVREDFLDNTTEAKSYRDALYKFMVDTAVLLGANSSRAEHDMKSVLRLEIKIA 282

  Fly   197 KEIAPLDNAIQEMYKSDMKFEHYARDAAPVKRIS-LGQL-EIYGVSLTKYLEIVFGRPFSPDFVV 259
            :.:.|.:|...|...:.|.....   :|.:.:.. ||.: ::....|..:|:.:  .| |.:.||
  Rat   283 EIMIPHENRTSEAMYNKMNISEL---SAMIPQFDWLGYIKKVIDTRLYPHLKDI--GP-SENVVV 341

  Fly   260 HVENLYYLRGLQNLMTAVPSQVVANY------------LTARFSF-YIMF--------TFMKHGD 303
            .|..  |.:.|..::.|...:.:|||            |:.||.: ::.|        |.:...|
  Rat   342 RVPQ--YFKDLFRILGAERKKTIANYLVWRMVYSRIPNLSRRFQYRWLEFSRVIQGTTTLLPQWD 404

  Fly   304 SCVTTMRQSMEFASNLLFEERILGRKKLRSYQNQAGKIFDAIRQQLNIRLERNVLKLPPAEISLL 368
            .||..:..::.:.                     .||:|      :|:..:.:       :..::
  Rat   405 KCVNFIESALPYV---------------------VGKMF------VNVHFQED-------KKEMM 435

  Fly   369 QKKLNGLSLSIGNLPGKAGHRRFVTRYYKELEFADDEELATAHLKVLEHRTRAELSLLDQPNF-- 431
            ::.:.|:..:            |:....||.|:.|    |....|..| :.||.|:.:..|.|
  Rat   436 EELIEGVRWA------------FIDMLEKENEWMD----AGTKRKAQE-KARAVLAKVGYPEFIM 483

  Fly   432 ------------------------KDRRYMLHSYPISNFFF------ETAYEENGNTIYVAY 463
                                    :.|:|:..    |:||:      :|.:..|..|:...|
  Rat   484 NDTYVNEDLKAIKFSESDYFGNVLQTRKYLAQ----SDFFWLRKAVPKTEWFTNPTTVNAFY 541

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl3	NP_608904.1	GluZincin	42..581	CDD:301352	95/539 (18%)
Phex	NP_037136.2	M13	74..740	CDD:341056	95/539 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810