DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl3 and Kel

DIOPT Version :9

Sequence 1:	NP_608904.1	Gene:	Nepl3 / 326172	FlyBaseID:	FBgn0031678	Length:	629	Species:	Drosophila melanogaster
Sequence 2:	NP_115929.3	Gene:	Kel / 23925	MGIID:	1346053	Length:	713	Species:	Mus musculus

Alignment Length:	765	Identity:	146/765 - (19%)
Similarity:	249/765 - (32%)	Gaps:	239/765 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 SRSYLSLSWLLL--LLCSTV------------------CSANPNLEIMKRMLDDMDEKVEPCHNF 48
            ||......|:||  |||..:                  |.....:|::...|...:..|.||.:|
Mouse    20 SRQLTRARWVLLAVLLCGLLLGSSMLWFYIFRNCGPCPCETPVCMELLDHYLASGNRSVAPCTDF 84

  Fly    49 YNSSQKNLKWHAFAT-----VSDQFQLLFDGIENE-----------VFEKHSFEEKLQRLYKICS 97
            :          :||.     .||.||.|.:  ||:           .:...|.|||..:.|..|.
Mouse    85 F----------SFACEKANGTSDSFQALTE--ENKSRLWRLLEAPGSWHLGSGEEKAFQFYNSCM 137

  Fly    98 TMERPSLLRYFELVKPGEDLNWPFLTPRGGKWPKEKF-QWMEALARLRRYGFNDIMFGMSIRQDP 161
            ..:.........|::..|:|....:|   |.|....| |.:..|  :.:|| :...|...:|..|
Mouse   138 DTDAIEASGSGPLIQIIEELGGWNIT---GNWTSLDFNQNLRLL--MSQYG-HFPFFRAYLRPHP 196

  Fly   162 NSDSGQPIVVF--------------EKKYDSLFR-FIESLQNIGL----PPKLAKEIAPLDNAI- 206
             :....||:..              :|.|..:.| ::..|..:|.    .|:.|::.|......
Mouse   197 -APPHTPIIQIDQPEFDILLQQEQEQKVYAQILREYVTYLNRLGTLLGSNPQEAQQHASWSIVFT 260

  Fly   207 ---------QEMYKSDMKFEHYA-----RDAAP-VKRISLGQLEIYGVSLTKYLEIVFGRPFSPD 256
                     |:..::..|..|..     ::.|| :..:|..|.....:||..          |..
Mouse   261 SRLFQFLRPQQQQQAQDKLFHVVTIDELQEMAPAIDWLSCLQAIFTPMSLNS----------SQT 315

  Fly   257 FVVHVENLYYLRGLQNLMTAVPSQVVANYLTARFSFYIMFTFMKHGDSCVTTMRQSMEFASNLLF 321
            .|||  :|.|||.:..|:    .:.:.|:..:..|:.|:        ..|.|:..:::.......
Mouse   316 LVVH--DLDYLRNMSQLV----EEGLLNHRESIQSYMIL--------GLVDTLSPALDTKFQEAR 366

  Fly   322 EERILGRKKLR-------------------------------------SYQNQAGKIFDAIRQQL 349
            .|.|...:||:                                     |.|:.|.::|..|:..:
Mouse   367 RELIQELRKLKERPPLPAYPRWMKCVEQTGAFFEPTLAALFVREAFGPSIQSAAMELFAEIKDAV 431

  Fly   350 NIRLERNVLKLPPAEISLLQK--------KLNGLSLSIGNLPGKAGHRRFVTRYYKELEFADDEE 406
            .|||::         :|.:.:        ||..|.:.:| .|.:|......|:.|      :|.:
Mouse   432 IIRLKK---------LSWISEETQKEALNKLAQLQVEMG-APKRAVKPDIATQEY------NDIQ 480

  Fly   407 LATAHLK-----VLEHRTRAELSLLDQPNFKDRRYMLHSYPISNFFFETAYEENGNTIYVAYDFL 466
            |..:.|:     |...|.|...|.| ||      :..|.:..|.:.....|..:.:.:......|
Mouse   481 LGPSFLQSFLSCVRSLRARNVQSFL-QP------FPYHRWQKSPWEVNAYYSISDHMVVFPAGLL 538

  Fly   467 ADASFDPDSHDIFKVTPLGIRFGL-------EMLKSFDLF-------NCKHHKVNMLQLFDDNQI 517
            ....|.|.       .|..:.||.       |:|..|...       .|..|.:....|..:...
Mouse   539 QPPFFHPG-------YPRAVNFGAAGSIMAHELLHIFYQLLLPGGCPACDTHVLQEALLCLERHY 596

  Fly   518 TTAGDECVSAWTQDNLLSQRDQYLVVLHLVHEAYFAEGSKFSQR---------QPNFTTMSLREL 573
            .......:|::...:.|.:....:..:.:..:||       |:|         .||. .:|..:|
Mouse   597 AAFPLPSISSFNGSHTLLENAADIGGVAIAFQAY-------SKRIVEHTGELTLPNL-DLSPYQL 653

  Fly   574 FFFRFGQSSFGQTLYFG---SDFVEGGSPIN-----SLTRLPVFVRTFNC 615
            ||     .|:.|.:..|   .|..:..||.:     .|:..|.|.:.|:|
Mouse   654 FF-----RSYAQVMCRGLSSQDPQDPHSPPSLRVHGPLSNTPDFAKHFHC 698

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl3	NP_608904.1	GluZincin	42..581	CDD:301352	124/663 (19%)
Kel	NP_115929.3	M13	78..711	CDD:341056	135/707 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167841108
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	4	3.700