DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl3 and ECE1

DIOPT Version :9

Sequence 1:	NP_608904.1	Gene:	Nepl3 / 326172	FlyBaseID:	FBgn0031678	Length:	629	Species:	Drosophila melanogaster
Sequence 2:	XP_011539174.1	Gene:	ECE1 / 1889	HGNCID:	3146	Length:	778	Species:	Homo sapiens

Alignment Length:	739	Identity:	143/739 - (19%)
Similarity:	250/739 - (33%)	Gaps:	200/739 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 TVCSANPNLEIMKRMLDDMDEKVEPCHNFYNSS-----------QKNLKWHAFATVSDQFQLLFD 73
            :||.:...:.:...:|..||..|:|||:|::.:           ..:.:|..|:.:.:..|.:..
Human   105 SVCLSEACVSVTSSILSSMDPTVDPCHDFFSYACGGWIKANPVPDGHSRWGTFSNLWEHNQAIIK 169

  Fly    74 G-IENEVFEKHSFEEKLQRLYKICSTMERPSLLRYFELVKPGEDLNWPFLTPRGGKWPKEKFQWM 137
            . :||........|.|.|..|:.|....|...||...|::..|.|....:|   |.|.|:.||
Human   170 HLLENSTASVSEAERKAQVYYRACMNETRIEELRAKPLMELIERLGGWNIT---GPWAKDNFQ-- 229

  Fly   138 EALARLRRYGFNDIMFGMSIRQDPNSDSGQPIVVFEKKYDSLFRFIESLQNIGLPPKLAKEIAPL 202
            :.|..:..:......|.:.:..|..:.:...|.|.:             ..:|||.:
Human   230 DTLQVVTAHYRTSPFFSVYVSADSKNSNSNVIQVDQ-------------SGLGLPSR-------- 273

  Fly   203 DNAIQEMYKSDMKFEHYARDAAPVKRISLGQLEIYGVSLTKYL-----EIVFGRPFSP---DFVV 259
                           .|..:....:::..|.|. |.|.|.|.|     |.:  ||...   ||..
Human   274 ---------------DYYLNKTENEKVLTGYLN-YMVQLGKLLGGGDEEAI--RPQMQQILDFET 320

  Fly   260 HVEN-------------LYYLRGLQNLMTAVPSQVVANYLTARFSFYIMFTF-MKHGDSCVTTMR 310
            .:.|             :|:......|.|..|:   .|:|.  |...|.:.. :...:..|...:
Human   321 ALANITIPQEKRRDEELIYHKVTAAELQTLAPA---INWLP--FLNTIFYPVEINESEPIVVYDK 380

  Fly   311 QSMEFASNLL--FEERILGR-------KKLRSYQNQAGKIFDAIRQQLNIRLERNVLKLPPAEIS 366
            :.:|..|.|:  .:..:|..       :|..|:.:|  :..||..:.:.:........||..:..
Human   381 EYLEQISTLINTTDRCLLNNYMIWNLVRKTSSFLDQ--RFQDADEKFMEVMYGTKKTCLPRWKFC 443

  Fly   367 LLQKKLNGLSLSIGNLPGKA----GHRRFVTRYYKELEFADDEELATAHLKVLEHRTR------- 420
            :...: |.|..::|.:..||    ..:...|....|::.|.:|.|:|  ||.::..||
Human   444 VSDTE-NNLGFALGPMFVKATFAEDSKSIATEIILEIKKAFEESLST--LKWMDEETRKSAKEKA 505

  Fly   421 -AELSLLDQPNF----KDRRYMLHSY-PISNFFFETAYEENGNTIYVAYDFL------------- 466
             |..:::..|||    |:...:.:.| .:.:.:||.|......:..|..|.|
Human   506 DAIYNMIGYPNFIMDPKELDKVFNDYTAVPDLYFENAMRFFNFSWRVTADQLRKAPNRDQWSMTP 570

  Fly   467 --ADASFDPDSHDIF------------KVTP-------LGIRFGLEMLKSFDLFNCKHHKVNMLQ 510
              .:|.:.|..::|.            :.:|       :|:..|.|:..:||....::.|...|:
Human   571 PMVNAYYSPTKNEIVFPAGILQAPFYTRSSPKALNFGGIGVVVGHELTHAFDDQGREYDKDGNLR 635

  Fly   511 LFDDNQITTA---GDECVSAWTQDNLLSQRDQYLV-------------------VLHLVHEAYFA 553
            .:..|....|   ..||        ::.|...|.|                   .|...:.|| .
Human   636 PWWKNSSVEAFKRQTEC--------MVEQYSNYSVNGEPVNGRHTLGENIADNGGLKAAYRAY-Q 691

  Fly   554 EGSKFSQRQPNFTTMSL--RELFFFRFGQ--------SSFGQTLYFGSDFVEGGSP-----INSL 603
            ...|.:..:.:..|:.|  .:|||..|.|        .|..:.|     ..:..||     |.||
Human   692 NWVKKNGAEHSLPTLGLTNNQLFFLGFAQVWCSVRTPESSHEGL-----ITDPHSPSRFRVIGSL 751

  Fly   604 TRLPVFVRTFNCLAPGEQLTTTQK 627
            :....|...|.| .||..:....|
Human   752 SNSKEFSEHFRC-PPGSPMNPPHK 774

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl3	NP_608904.1	GluZincin	42..581	CDD:301352	125/664 (19%)
ECE1	XP_011539174.1	PepO	114..769	CDD:226118	140/723 (19%)
ECE1	XP_011539174.1	M13	127..776	CDD:189000	138/717 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150950
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740