Protein Alignment Nepl3 and nep-20

DIOPT Version :10

• Sequence 1: NP_608904.1
• Gene: Nepl3 / 326172
• FlyBaseID: FBgn0031678
• Length: 629
• Species: Drosophila melanogaster
• Sequence 2: NP_001317749.1
• Gene: nep-20 / 188176
• WormBaseID: WBGene00020293
• Length: 834
• Species: Caenorhabditis elegans
• Alignment Length: 725
• Identity: 143/725 - (19%)
• Similarity: 264/725 - (36%)
• Gaps: 194/725 - (26%)

  Fly    10 LSWLLLLLCS------TVCSANPNLEIMKRMLDDMDEKVEPCHNFYNSSQKNLKWHAFATVSDQF 68
            |.||||.:.:      ::|.:...:.:...:....|..|..|||||.::....|.|   ...|:.
 Worm   197 LFWLLLFIGARQDEKPSLCESPQCITLAFELSAYQDTSVSKCHNFYKATCGKYKHH---QALDKH 258

  Fly    69 QLLFDGIENEVFEK--------------HSFEEKLQRLYKICSTMERPSLLRYFELVKPGEDLNW 119
            :   |..:.||.::              ..||..::.::..|:...:..  .|.::.|..|.:
 Worm   259 R---DAKKKEVVKRIVREFLRRNESSITSKFEPAIRLMFGKCNKFSQNK--TYLDIFKDIEKI-- 316

  Fly   120 PFLTPRGGKWPKEKFQWMEALARLRRY-------GFNDI-MFGMSIRQDPNSDSGQ-PIVV--FE 173
                   |.||..|..|::.:..|..|       ||.|. :|.:..||   ...|| |::.  .:
 Worm   317 -------GPWPVLKSDWVDVMFNLNDYLLSLVELGFTDFGLFKLEFRQ---LAFGQFPVIAPSEQ 371

  Fly   174 KKYDSLFRFI-ESLQNIGLPPKLAKEIAPLDNAIQEMYKSDMKFEHYARDAAPVKRISLGQLEIY 237
            |:.:.|.:.| |.|:..|:.....|    |...::|..:...:..|.:.:...||.|......:
 Worm   372 KQGNQLEKIILEILEANGVQADRQK----LSKYLREYSEFKSQLRHMSLEGTSVKYIRYNASTL- 431

  Fly   238 GVSLTKYLEIVFGRPFSPDFVVHVE--------NLYYLRGLQNLMTAVPSQVVANYLTARFSFYI 294
            .|:::..::.:.....|...|..::        :.::.:.|..::.....:.:||||.  |.|..
 Worm   432 SVNISALVQKMAPMSTSSGLVRRIQSGILITNSSSFFGKNLDAIIQQTHKRTLANYLI--FHFID 494

  Fly   295 MFTF-----MKHGDSCVTTM--RQSMEFASNLLFEERILGRKKLRSYQNQAGKIFDAIRQQLNIR 352
            ..||     .||.:..:..:  |.|::..|....:|...|                 :..::...
 Worm   495 AVTFDLTSGAKHSEHTLIDLLPRGSLQVLSQDFVDEEDQG-----------------VMVEMAKD 542

  Fly   353 LERNVLKLPPAEISLLQKKLNGLSLSIGNLPGKAGHRR----------FVTRYYKELEFADDEEL 407
            |:::|:::    ||      .|.||..|:|..:...||          .||:|..|:...:.|:|
 Worm   543 LKKHVVEM----IS------EGSSLDKGHLVFEEKERRKLIRKVQDILVVTKYPLEILNQNFEKL 597

  Fly   408 ATAHLKVLEHRTRAELSLLDQPNFKDRRY---MLHSY------PISNFFFETA-YEENGNTIYVA 462
            ...:...| |:...:|          ||:   .|..|      |.....:.:| ||:..|.:.:.
 Worm   598 NLTYSDSL-HKIIQKL----------RRFRSEQLIEYLGGDLDPTDKGMWGSAHYEQATNDLIII 651

  Fly   463 YDFLADASFDPDSHDIFKVTPLGIRFGLEMLKSFDLFNC----KHH-----KVNMLQLFDDNQIT 518
            ...:....||....:...:..:|.....|:.:|.|....    |.|     |...|:.||:|
 Worm   652 APIIDGPYFDTSYPNYVNIFFMGFIISRELGRSLDSVRIRKDEKGHTENWLKSESLKRFDNN--- 713

  Fly   519 TAGDECVSAW----TQDNLLSQRDQYLVVLHLVHEAYFAEGSKFSQRQPN---------FTTMSL 570
                  |..|    |....|::    ::..|:.|||.|....|: :::.|         :.:|::
 Worm   714 ------VKCWRKKITGTRFLNE----MLADHVGHEASFMALKKW-EKEMNGTIVEKIRGYESMTM 767

  Fly   571 RELFFFRFGQSSFGQTLYFGSDFVEGGSP---------------IN-SLTRLPVFVRTFNCLAPG 619
            .::||..       |.|||...  .|||.               :| :...:|.|.:.|.| :..
 Worm   768 EQIFFHL-------QALYFCRP--PGGSTGELTAKDARQHYSTRVNEAFKNMPQFAKAFGC-SSN 822

  Fly   620 EQLTTTQKST 629
            :.:.:..|.|
 Worm   823 QNMNSKTKCT 832

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl3	NP_608904.1	GluZincin	42..>434	CDD:472708	86/442 (19%)
nep-20	NP_001317749.1	PHA02030	<71..139	CDD:222843
		GluZincin	238..832	CDD:472708	134/682 (20%)