Protein Alignment Nepl3 and nep-23

DIOPT Version :10

• Sequence 1: NP_608904.1
• Gene: Nepl3 / 326172
• FlyBaseID: FBgn0031678
• Length: 629
• Species: Drosophila melanogaster
• Sequence 2: NP_503004.2
• Gene: nep-23 / 178472
• WormBaseID: WBGene00013785
• Length: 714
• Species: Caenorhabditis elegans
• Alignment Length: 708
• Identity: 132/708 - (18%)
• Similarity: 250/708 - (35%)
• Gaps: 188/708 - (26%)

  Fly    17 LCSTVCSANPNLEIMKRMLDDMDEKVEPCHNFYNSSQKNLKWHAFATVSDQFQLLFDGIENEVFE 81
            |...||.....:.:..::.:..|...:||.|||.|.......|:..:...:..|:...:..|...
 Worm    71 LKKNVCQTPECITLAHQLHNYHDPSADPCDNFYQSVCGKQHEHSLKSGLAKKHLILRNLIRETIT 135

  Fly    82 KHSF------EEKLQRLYKICSTMERPS--------LLRYFELVKPGEDL-NWPFLTPRGGK-WP 130
            ....      |.::::.:.|||..:|.:        .||  ::.:..:.: :|    |.|.: |.
 Worm   136 NRKVTPTSKSENEMRKFHGICSKYQRANSSSDIAQQALR--DIFRDVQSIGSW----PAGSRNWN 194

  Fly   131 KEKFQWMEALARLRRYGFNDI-MFGMSIRQDPNSDSGQPIVVFEKKYDSLFRFIESLQNI----G 190
            :..|...|.|..|.:.|..:. :|.:|.:.     ..|.::..|:...:..:...::.||    |
 Worm   195 ESDFNLNEMLNNLVKLGQRNFGLFQISFKY-----RDQLLISAEEHRRNYSKLEPTILNIFETNG 254

  Fly   191 LPP---KLAKEI---APLDNAIQEMYKSDM--KFEHYARD---------------AAPVKRISLG 232
            |.|   :|.|::   |.|:..::..|..|.  |.:....|               .:|.|...:.
 Worm   255 LVPDRIQLLKDLEGFASLEALLKNHYYLDNMDKMKPAVLDDLVPSVDFMGLVKAMISPGKEHLMP 319

  Fly   233 QLEIYGVSLTKYLEIVFGRPFSPDFVVHVENLYYLRGLQNLMTAVPSQVVANYLTARFSF----- 292
            ::|:....|.:.|             .:.||:    .|:.::...|.:.:||||.  |:|
 Worm   320 KIELKTSVLNQTL-------------FNDENM----NLEAIILDTPKRTLANYLI--FNFIDSSL 365

  Fly   293 -YIMF-TFMKHGDSCVTTMRQSMEFASNLLFEERILGRKKLRSYQNQAGK-IFDAIRQQLNIRLE 354
             :::| |..:.|::|...:...:..||..:|         :|:|.::..: :...:.::..|.|.
 Worm   366 DHLVFETTSQKGNTCEDKVITYLPRASLRVF---------IRNYVDKENRDLITQLAEKTRIALH 421

  Fly   355 RNV-----LKLPPAEISLLQKKLNGLSLSIG-----NLPGKAGHRRFVTRYYKELEFADDEELAT 409
            ..|     ||....:::|  .|:|.:...||     ..||.      :...:|.|.....:...|
 Worm   422 TLVQNSTWLKAESKQLAL--DKINAMGKMIGYPDFFEPPGT------LDGMFKNLNLDSSDTYYT 478

  Fly   410 AHLKVLEHRTRAELSLLDQPNFKD---RRYMLHSYPISNFFFETAYEENGNTIYVAYDFLADASF 471
            |..|:..:....::....:....|   |.:.:::|          |...||.:.....|..|..|
 Worm   479 ALNKLERYFVEQKMDYFAEETPLDPDLRVFEMNAY----------YYIPGNQLNFLAPFFDDPMF 533

  Fly   472 DPDSHDIFKVTPLGIRFGLEMLKSFD----LFNCKHHKV------------------NMLQLFDD 514
            |....|...:...|...|.||..:|.    |...:..:|                  |....:||
 Worm   534 DSTYPDYVNIAMSGNIIGHEMGHAFGPHAILRTVRGREVWMKPEELAEYESRAQCLANQYSEYDD 598

  Fly   515 ---NQITTAG---DECVS-------AWTQDNLLSQRDQYLVV---LHLVHEAYFAEGSKFSQRQP 563
               .::...|   ||.|:       :|.....|...:...::   .:.:.:.||..|:     ..
 Worm   599 PDFGRVFDGGKVIDELVADNIGREVSWKMFKSLDLTNATRIIGFEDYDIDQLYFRVGA-----LT 658

  Fly   564 NFTTMSLRELFFFRFGQSSFGQTLYFGSDFVEGGSP-----INSL-TRLPVFVRTFNC 615
            :.|..::|:|               .||  :|...|     :|.: ..||.|.|.|||
 Worm   659 HCTPHAMRDL---------------KGS--IESSHPRKAFRVNGVYANLPEFARAFNC 699

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl3	NP_608904.1	GluZincin	42..>434	CDD:472708	84/456 (18%)
nep-23	NP_503004.2	M13	96..711	CDD:341056	128/683 (19%)