Protein Alignment Nepl3 and Ecel1

DIOPT Version :10

• Sequence 1: NP_608904.1
• Gene: Nepl3 / 326172
• FlyBaseID: FBgn0031678
• Length: 629
• Species: Drosophila melanogaster
• Sequence 2: NP_067281.2
• Gene: Ecel1 / 13599
• MGIID: 1343461
• Length: 775
• Species: Mus musculus
• Alignment Length: 727
• Identity: 135/727 - (18%)
• Similarity: 255/727 - (35%)
• Gaps: 191/727 - (26%)

  Fly    18 CSTVCSANPNLEIMKRMLD-DMDEKVEPCHNFYNSS-----------QKNLKWHAFATVSDQFQL 70
            |...|..........|.|. ::|..::||.:||:.:           ...|.:...|.:.:|
Mouse    96 CPEGCPERKAFARAARFLSANLDASIDPCQDFYSFACGGWLRRHAIPDDKLTYGTIAAIGEQ--- 157

  Fly    71 LFDGIENEVFEKHSFEEKLQRL-------------------YKICSTME-------RPSLLRYFE 109
                          .||:|:||                   ::.|..|.       ||.|    |
Mouse   158 --------------NEERLRRLLARPTGGPGGAAQRKVRAFFRSCLDMREIERLGPRPML----E 204

  Fly   110 LVKP--GEDLNWPFLTPRGGKWPKE----KFQWMEALARLRRYGFNDIMFGMSIRQDPNSDSGQP 168
            :::.  |.||......|...:|...    |.|.:.:.|.|         |.:::..|..:.|...
Mouse   205 VIEDCGGWDLGGAADRPGAARWDLNRLLYKAQGVYSAAAL---------FSLTVSLDDRNSSRYV 260

  Fly   169 IVVFE------------------KKYDSLFR-FIESLQNI---GLPPKLAKEIAPLDNAIQEMYK 211
            |.:.:                  :|..:.:| |::.|..:   ....:.|:||..|:..:..:..
Mouse   261 IRIDQDGLTLPERTLYLAQDEESEKILAAYRVFMQRLLRLLGADAVEQKAQEILQLEQRLANISV 325

  Fly   212 SDMKFEHYARD-AAPVKRISLGQLE--IYGVSLTKYLEIVFGRPFSPDFVVHVENLYYLRGLQNL 273
            |:  ::...|| ::...:::||||:  |..:.....|:.:|...||.:..|.:....|::.:..|
Mouse   326 SE--YDDLRRDVSSAYNKVTLGQLQKIIPHLQWKWLLDQIFQEDFSEEEEVVLLATDYMQQVSQL 388

  Fly   274 MTAVPSQVVANYLTAR----FSFYIMFTF----------MKHGDS-------CVTTMRQSMEFAS 317
            :.:.|.:::.|||..|    .|.::...|          |:..|.       |:....:....|.
Mouse   389 IRSTPRRILHNYLVWRVVVVLSEHLSSPFREALHELAKEMEGNDKPQELARVCLGQANRHFGMAL 453

  Fly   318 NLLF-EERILGRKKLRSYQNQAGKIFDAIRQQLNIRLERNVLKLPPAEI-SLLQKKLNGLSLSIG 380
            ..|| .|......|.:..|     :.:.|:..|..|||.  |....|:. :..:.||..:.:.:
Mouse   454 GALFVHEHFSAASKAKVQQ-----LVEDIKYILGQRLEE--LDWMDAQTKAAARAKLQYMMVMV- 510

  Fly   381 NLPGKAGHRRFVTR---YYKELEFADDEELATAHLKVLEHRTRAELSL--------LDQPNFKDR 434
                  |:..|:.:   ..||.||...|:   .:.|.:.:..|..:.|        :|:.::...
Mouse   511 ------GYPDFLLKPEAVDKEYEFEVHEK---TYFKNILNSIRFSIQLSVKKIRQEVDKSSWLLP 566

  Fly   435 RYMLHSYPISNFFFETAYEENGNTIYVAYDFLADASFDPDSHDIFKVTPLGIRFGLEMLKSFDLF 499
            ...|::|          |..|.|.:......|....:|||.........:|...|.|:...:|.:
Mouse   567 PQALNAY----------YLPNKNQMVFPAGILQPTLYDPDFPQSLNYGGIGTIIGHELTHGYDDW 621

  Fly   500 NCKHHKV-NMLQLFDDNQIT--TAGDECVSAWTQDNLLSQRDQYLVVLHLVHE----------AY 551
            ..::.:. |:|..:.:...:  ....||: ....|| .:..:|.:...|.:.|          ||
Mouse   622 GGQYDRSGNLLHWWTETSYSHFLRKAECI-VRLYDN-FTVYNQRVNGKHTLGENIADMGGLKLAY 684

  Fly   552 FAEGSKFSQRQPNFTTMSLR----ELFFFRFGQS----SFGQTLYFGSDFVEGGSP-----INSL 603
            :|......:..|......|:    :|||..|.|:    ...|::|. ....:..:|     :.|:
Mouse   685 YAYQKWVREHGPEHPLHRLKYTHNQLFFIAFAQNWCIKRRSQSIYL-QVLTDKHAPEHYRVLGSV 748

  Fly   604 TRLPVFVRTFNC 615
            ::...|.|.|:|
Mouse   749 SQFEEFGRAFHC 760

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl3	NP_608904.1	GluZincin	42..>434	CDD:472708	90/493 (18%)
Ecel1	NP_067281.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	30..52
		M13	121..773	CDD:341056	130/702 (19%)