Protein Alignment Nepl3 and Eef1ece2

DIOPT Version :10

• Sequence 1: NP_608904.1
• Gene: Nepl3 / 326172
• FlyBaseID: FBgn0031678
• Length: 629
• Species: Drosophila melanogaster
• Sequence 2: NP_808810.1
• Gene: Eef1ece2 / 110599584
• MGIID: 6121518
• Length: 910
• Species: Mus musculus
• Alignment Length: 794
• Identity: 150/794 - (18%)
• Similarity: 251/794 - (31%)
• Gaps: 277/794 - (34%)

  Fly     8 LSLSWLLLLLCS-----------------TVCSANPNLEIMKRMLDDMDEKVEPCHNFYNSS--- 52
            |.|:.|:|:|.:                 :.|.....:.:..::|:.:|..|.||.:||..|
Mouse   208 LVLAGLILVLAALLLGCLVALWVHRDPAHSTCVTEACIRVAGKILESLDRGVSPCQDFYQFSCGG 272

  Fly    53 --QKN------LKWHAFATVSDQFQ-LLFDGIENEVFEKHS-FEEKLQRLYKICSTMERPSLLRY 107
              ::|      .:|:.|.::.||.| :|...:||..|...| .|.|.:..|..|...||...|.
Mouse   273 WIRRNPLPNGRSRWNTFNSLWDQNQAILKHLLENTTFNSSSEAERKTRSFYLSCLQSERIEKLG- 336

  Fly   108 FELVKPGEDL-----NWPFLTPRGGKWPKEKFQWMEAL------------------ARLRRYGFN 149
               .||..||     .|...    |.|.::.|  |:.|                  |..:....|
Mouse   337 ---AKPLRDLIDKIGGWNIT----GPWDEDSF--MDVLKAVAGTYRATPFFTVYVSADSKSSNSN 392

  Fly   150 DIMFGMSIRQDPNSD--------------------------SGQPIVVFEKKYDSLFRFIESLQN 188
            .|....|....|:.|                          .|||....|:....|...|: |.|
Mouse   393 IIQVDQSGLFLPSRDYYLNRTANEKVLTAYLDYMVELGVLLGGQPTSTREQMQQVLELEIQ-LAN 456

  Fly   189 IGLPPKLAKEIAPLDNAIQEMYKSDMKFEHYARDAAPVKRISLGQLEIYGVS---------LTKY 244
            |.:|              |:..:.:.|..|         ::|:.:|:....:         |...
Mouse   457 ITVP--------------QDQRRDEEKIYH---------KMSISELQALAPAVDWLEFLSFLLSP 498

  Fly   245 LEIVFGRPFSPDFVVHVENLYYLRGLQNLMTAVPSQVVANYLTARFSFYIMFTFMKHGDSCVTTM 309
            ||:....|      |.|....||:.:..|:......::.|||        ::..::   ...:::
Mouse   499 LELGDSEP------VVVYGTEYLQQVSELINRTEPSILNNYL--------IWNLVQ---KTTSSL 546

  Fly   310 RQSMEFASNLLFEERILGRKKLRSYQNQAGKIFDAIRQQLNIRLERNVLKLPPAEISLLQKKLNG 374
            .|..|.|...|. |.:.|.||                            ...|...:.:....:.
Mouse   547 DQRFETAQEKLL-ETLYGTKK----------------------------SCTPRWQTCISNTDDA 582

  Fly   375 LSLSIGNLPGKAGHRR----FVTRYYKELEFADDEELATAHLKVLEHRTR--------AELSLLD 427
            |..::|:|..||...|    .......|:..|.:|.|  ..|..::.:||        |...::.
Mouse   583 LGFALGSLFVKATFDRQSKEIAEGMINEIRSAFEETL--GDLVWMDEKTRLAAKEKADAIYDMIG 645

  Fly   428 QPNF----KDRRYMLHSYPISNFFFETAYEENGNTIY-VAYDFLADASFDPDSHDIFKVTP---- 483
            .|:|    |:...:...|.:|    |.::.:|...:| .:...:||....|.|.|.:.:||
Mouse   646 FPDFILEPKELDDVYDGYEVS----EDSFFQNMLNLYNFSAKVMADQLRKPPSRDQWSMTPQTVN 706

  Fly   484 ----------------------------------LGIRFGLEMLKSFDLFNCKHHKVNMLQLFDD 514
                                              :|:..|.|:..:||....::.|...|:.:..
Mouse   707 AYYLPTKNEIVFPAGILQAPFYAHNHPKALNFGGIGVVMGHELTHAFDDQGREYDKEGNLRPWWQ 771

  Fly   515 NQITTAGDECVSAWTQDNLLSQRDQYLV-------------------VLHLVHEAYFAEGSKFSQ 560
            |:..||.....:...:     |..||.|                   .|...:.||.|...|..:
Mouse   772 NESLTAFQNHTACMEE-----QYSQYQVNGERLNGLQTLGENIADNGGLKAAYNAYKAWLRKHGE 831

  Fly   561 RQP-NFTTMSLRELFFFRFGQ--------SSFGQTLYFGSDFVEGGSP-----INSLTRLPVFVR 611
            .|| ....::..:|||..|.|        .|..:.|     ..:..||     :.:|:....|:|
Mouse   832 EQPLPAVGLTNHQLFFVGFAQVWCSVRTPESSHEGL-----VTDPHSPARFRVLGTLSNSRDFLR 891

  Fly   612 TFNC-----LAPGE 620
            .|.|     :.||:
Mouse   892 HFGCPVGSPMNPGQ 905

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl3	NP_608904.1	GluZincin	42..>434	CDD:472708	93/478 (19%)
Eef1ece2	NP_808810.1	UbiG	46..>128	CDD:441829
		M13	259..908	CDD:341056	142/743 (19%)