DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nepl3 and Gm49333

DIOPT Version :9

Sequence 1:	NP_608904.1	Gene:	Nepl3 / 326172	FlyBaseID:	FBgn0031678	Length:	629	Species:	Drosophila melanogaster
Sequence 2:	NP_808810.1	Gene:	Gm49333 / 110599584	MGIID:	6121518	Length:	910	Species:	Mus musculus

Alignment Length:	794	Identity:	150/794 - (18%)
Similarity:	251/794 - (31%)	Gaps:	277/794 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LSLSWLLLLLCS-----------------TVCSANPNLEIMKRMLDDMDEKVEPCHNFYNSS--- 52
            |.|:.|:|:|.:                 :.|.....:.:..::|:.:|..|.||.:||..|
Mouse   208 LVLAGLILVLAALLLGCLVALWVHRDPAHSTCVTEACIRVAGKILESLDRGVSPCQDFYQFSCGG 272

  Fly    53 --QKN------LKWHAFATVSDQFQ-LLFDGIENEVFEKHS-FEEKLQRLYKICSTMERPSLLRY 107
              ::|      .:|:.|.::.||.| :|...:||..|...| .|.|.:..|..|...||...|.
Mouse   273 WIRRNPLPNGRSRWNTFNSLWDQNQAILKHLLENTTFNSSSEAERKTRSFYLSCLQSERIEKLG- 336

  Fly   108 FELVKPGEDL-----NWPFLTPRGGKWPKEKFQWMEAL------------------ARLRRYGFN 149
               .||..||     .|...    |.|.::.|  |:.|                  |..:....|
Mouse   337 ---AKPLRDLIDKIGGWNIT----GPWDEDSF--MDVLKAVAGTYRATPFFTVYVSADSKSSNSN 392

  Fly   150 DIMFGMSIRQDPNSD--------------------------SGQPIVVFEKKYDSLFRFIESLQN 188
            .|....|....|:.|                          .|||....|:....|...|: |.|
Mouse   393 IIQVDQSGLFLPSRDYYLNRTANEKVLTAYLDYMVELGVLLGGQPTSTREQMQQVLELEIQ-LAN 456

  Fly   189 IGLPPKLAKEIAPLDNAIQEMYKSDMKFEHYARDAAPVKRISLGQLEIYGVS---------LTKY 244
            |.:|              |:..:.:.|..|         ::|:.:|:....:         |...
Mouse   457 ITVP--------------QDQRRDEEKIYH---------KMSISELQALAPAVDWLEFLSFLLSP 498

  Fly   245 LEIVFGRPFSPDFVVHVENLYYLRGLQNLMTAVPSQVVANYLTARFSFYIMFTFMKHGDSCVTTM 309
            ||:....|      |.|....||:.:..|:......::.|||        ::..::   ...:::
Mouse   499 LELGDSEP------VVVYGTEYLQQVSELINRTEPSILNNYL--------IWNLVQ---KTTSSL 546

  Fly   310 RQSMEFASNLLFEERILGRKKLRSYQNQAGKIFDAIRQQLNIRLERNVLKLPPAEISLLQKKLNG 374
            .|..|.|...|. |.:.|.||                            ...|...:.:....:.
Mouse   547 DQRFETAQEKLL-ETLYGTKK----------------------------SCTPRWQTCISNTDDA 582

  Fly   375 LSLSIGNLPGKAGHRR----FVTRYYKELEFADDEELATAHLKVLEHRTR--------AELSLLD 427
            |..::|:|..||...|    .......|:..|.:|.|  ..|..::.:||        |...::.
Mouse   583 LGFALGSLFVKATFDRQSKEIAEGMINEIRSAFEETL--GDLVWMDEKTRLAAKEKADAIYDMIG 645

  Fly   428 QPNF----KDRRYMLHSYPISNFFFETAYEENGNTIY-VAYDFLADASFDPDSHDIFKVTP---- 483
            .|:|    |:...:...|.:|    |.::.:|...:| .:...:||....|.|.|.:.:||
Mouse   646 FPDFILEPKELDDVYDGYEVS----EDSFFQNMLNLYNFSAKVMADQLRKPPSRDQWSMTPQTVN 706

  Fly   484 ----------------------------------LGIRFGLEMLKSFDLFNCKHHKVNMLQLFDD 514
                                              :|:..|.|:..:||....::.|...|:.:..
Mouse   707 AYYLPTKNEIVFPAGILQAPFYAHNHPKALNFGGIGVVMGHELTHAFDDQGREYDKEGNLRPWWQ 771

  Fly   515 NQITTAGDECVSAWTQDNLLSQRDQYLV-------------------VLHLVHEAYFAEGSKFSQ 560
            |:..||.....:...:     |..||.|                   .|...:.||.|...|..:
Mouse   772 NESLTAFQNHTACMEE-----QYSQYQVNGERLNGLQTLGENIADNGGLKAAYNAYKAWLRKHGE 831

  Fly   561 RQP-NFTTMSLRELFFFRFGQ--------SSFGQTLYFGSDFVEGGSP-----INSLTRLPVFVR 611
            .|| ....::..:|||..|.|        .|..:.|     ..:..||     :.:|:....|:|
Mouse   832 EQPLPAVGLTNHQLFFVGFAQVWCSVRTPESSHEGL-----VTDPHSPARFRVLGTLSNSRDFLR 891

  Fly   612 TFNC-----LAPGE 620
            .|.|     :.||:
Mouse   892 HFGCPVGSPMNPGQ 905

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl3	NP_608904.1	GluZincin	42..581	CDD:301352	131/692 (19%)
Gm49333	NP_808810.1	AdoMet_MTases	63..>128	CDD:302624
		PepO	248..901	CDD:226118	142/748 (19%)
		M13	259..908	CDD:189000	142/743 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167841076
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740