DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nepl3 and EEF1AKMT4-ECE2

DIOPT Version :9

Sequence 1:	NP_608904.1	Gene:	Nepl3 / 326172	FlyBaseID:	FBgn0031678	Length:	629	Species:	Drosophila melanogaster
Sequence 2:	NP_055508.3	Gene:	EEF1AKMT4-ECE2 / 110599583	HGNCID:	53615	Length:	883	Species:	Homo sapiens

Alignment Length:	703	Identity:	137/703 - (19%)
Similarity:	230/703 - (32%)	Gaps:	237/703 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MMESRSYLSL-----SWL---LLLLC-------------STVCSANPNLEIMKRMLDDMDEKVEP 44
            ::.||:.|.|     |.|   |||.|             .:.|.....:.:..::|:.:|..|.|
Human   170 LLGSRTQLELVLAGASLLLAALLLGCLVALGVQYHRDPSHSTCLTEACIRVAGKILESLDRGVSP 234

  Fly    45 CHNFYNSS-----QKN------LKWHAFATVSDQFQ-LLFDGIENEVFEKHS-FEEKLQRLYKIC 96
            |.:||..|     ::|      .:|:.|.::.||.| :|...:||..|...| .|:|.||.|..|
Human   235 CEDFYQFSCGGWIRRNPLPDGRSRWNTFNSLWDQNQAILKHLLENTTFNSSSEAEQKTQRFYLSC 299

  Fly    97 STMERPSLLRYFELVKPGEDL-----NWPFLTPRGGKWPKEKFQWMEALARLRRYGFNDIMFGMS 156
            ..:||...|.    .:|..||     .|...    |.|.::.|  ||.|..:.........|.:.
Human   300 LQVERIEELG----AQPLRDLIEKIGGWNIT----GPWDQDNF--MEVLKAVAGTYRATPFFTVY 354

  Fly   157 IRQDPNSDSGQPIVV------------------FEKKYDSLFRFIESL----------------Q 187
            |..|..|.:...|.|                  .||...:...::|.|                |
Human   355 ISADSKSSNSNVIQVDQSGLFLPSRDYYLNRTANEKVLTAYLDYMEELGMLLGGRPTSTREQMQQ 419

  Fly   188 NIGLPPKLAKEIAPLDNAIQEMYKSDMKFEHYARDAAPVKRISLGQLEIYGVS---------LTK 243
            .:.|..:||....|     |:..:.:.|..|         ::|:.:|:....|         |..
Human   420 VLELEIQLANITVP-----QDQRRDEEKIYH---------KMSISELQALAPSMDWLEFLSFLLS 470

  Fly   244 YLEIVFGRPFSPDFVVHVENLYYLRGLQNLMTAVPSQVVANYLTARFSFYIMFTFMKHGDSCVTT 308
            .||:....|      |.|..:.||:.:..|:......::.|||        ::..::   ...::
Human   471 PLELSDSEP------VVVYGMDYLQQVSELINRTEPSILNNYL--------IWNLVQ---KTTSS 518

  Fly   309 MRQSMEFASNLLFEERILGRKK--LRSYQNQAGKIFDAIRQQLNIRLERNVLKLPPAEISLLQKK 371
            :.:..|.|...|. |.:.|.||  :..:|.......||
Human   519 LDRRFESAQEKLL-ETLYGTKKSCVPRWQTCISNTDDA--------------------------- 555

  Fly   372 LNGLSLSIGNLPGKAGHRRFVTRYYKELEFADDEELATA------HLKVLEHRTR--------AE 422
               |..::|:|..||    ...|..||:......|:.||      .|..::.:||        |.
Human   556 ---LGFALGSLFVKA----TFDRQSKEIAEGMISEIRTAFEEALGQLVWMDEKTRQAAKEKADAI 613

  Fly   423 LSLLDQPNF----KDRRYMLHSYPISNFFFETAYEENGNTIY-VAYDFLADASFDPDSHDIFKVT 482
            ..::..|:|    |:...:...|.||    |.::.:|...:| .:...:||....|.|.|.:.:|
Human   614 YDMIGFPDFILEPKELDDVYDGYEIS----EDSFFQNMLNLYNFSAKVMADQLRKPPSRDQWSMT 674

  Fly   483 P--------------------------------------LGIRFGLEMLKSFDLFNCKHHKVNML 509
            |                                      :|:..|.|:..:||....::.|...|
Human   675 PQTVNAYYLPTKNEIVFPAGILQAPFYARNHPKALNFGGIGVVMGHELTHAFDDQGREYDKEGNL 739

  Fly   510 QLFDDNQITTAGDECVSAWTQDNLLSQRDQYLVVLHLVHEAYFAEGSKFSQRQ 562
            :                .|.|:..|:....:...:...:..|...|.:.:.||
Human   740 R----------------PWWQNESLAAFRNHTACMEEQYNQYQVNGERLNGRQ 776

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl3	NP_608904.1	GluZincin	42..581	CDD:301352	124/641 (19%)
EEF1AKMT4-ECE2	NP_055508.3	Methyltransferase-like region. /evidence=ECO:0000305	1..160
		Methyltransf_25	62..>128	CDD:316196
		S-adenosyl-L-methionine binding. /evidence=ECO:0000250\|UniProtKB:P0DPD7	88..89
		S-adenosyl-L-methionine binding. /evidence=ECO:0000250\|UniProtKB:P0DPD7	113..114
		M13	232..881	CDD:189000	124/641 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150960
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740