DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl3 and Ece2

DIOPT Version :9

Sequence 1:	NP_608904.1	Gene:	Nepl3 / 326172	FlyBaseID:	FBgn0031678	Length:	629	Species:	Drosophila melanogaster
Sequence 2:	NP_647454.2	Gene:	Ece2 / 107522	MGIID:	1101356	Length:	763	Species:	Mus musculus

Alignment Length:	794	Identity:	150/794 - (18%)
Similarity:	251/794 - (31%)	Gaps:	277/794 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LSLSWLLLLLCS-----------------TVCSANPNLEIMKRMLDDMDEKVEPCHNFYNSS--- 52
            |.|:.|:|:|.:                 :.|.....:.:..::|:.:|..|.||.:||..|
Mouse    61 LVLAGLILVLAALLLGCLVALWVHRDPAHSTCVTEACIRVAGKILESLDRGVSPCQDFYQFSCGG 125

  Fly    53 --QKN------LKWHAFATVSDQFQ-LLFDGIENEVFEKHS-FEEKLQRLYKICSTMERPSLLRY 107
              ::|      .:|:.|.::.||.| :|...:||..|...| .|.|.:..|..|...||...|.
Mouse   126 WIRRNPLPNGRSRWNTFNSLWDQNQAILKHLLENTTFNSSSEAERKTRSFYLSCLQSERIEKLG- 189

  Fly   108 FELVKPGEDL-----NWPFLTPRGGKWPKEKFQWMEAL------------------ARLRRYGFN 149
               .||..||     .|...    |.|.::.|  |:.|                  |..:....|
Mouse   190 ---AKPLRDLIDKIGGWNIT----GPWDEDSF--MDVLKAVAGTYRATPFFTVYVSADSKSSNSN 245

  Fly   150 DIMFGMSIRQDPNSD--------------------------SGQPIVVFEKKYDSLFRFIESLQN 188
            .|....|....|:.|                          .|||....|:....|...|: |.|
Mouse   246 IIQVDQSGLFLPSRDYYLNRTANEKVLTAYLDYMVELGVLLGGQPTSTREQMQQVLELEIQ-LAN 309

  Fly   189 IGLPPKLAKEIAPLDNAIQEMYKSDMKFEHYARDAAPVKRISLGQLEIYGVS---------LTKY 244
            |.:|              |:..:.:.|..|         ::|:.:|:....:         |...
Mouse   310 ITVP--------------QDQRRDEEKIYH---------KMSISELQALAPAVDWLEFLSFLLSP 351

  Fly   245 LEIVFGRPFSPDFVVHVENLYYLRGLQNLMTAVPSQVVANYLTARFSFYIMFTFMKHGDSCVTTM 309
            ||:....|      |.|....||:.:..|:......::.|||        ::..::   ...:::
Mouse   352 LELGDSEP------VVVYGTEYLQQVSELINRTEPSILNNYL--------IWNLVQ---KTTSSL 399

  Fly   310 RQSMEFASNLLFEERILGRKKLRSYQNQAGKIFDAIRQQLNIRLERNVLKLPPAEISLLQKKLNG 374
            .|..|.|...|. |.:.|.||                            ...|...:.:....:.
Mouse   400 DQRFETAQEKLL-ETLYGTKK----------------------------SCTPRWQTCISNTDDA 435

  Fly   375 LSLSIGNLPGKAGHRR----FVTRYYKELEFADDEELATAHLKVLEHRTR--------AELSLLD 427
            |..::|:|..||...|    .......|:..|.:|.|  ..|..::.:||        |...::.
Mouse   436 LGFALGSLFVKATFDRQSKEIAEGMINEIRSAFEETL--GDLVWMDEKTRLAAKEKADAIYDMIG 498

  Fly   428 QPNF----KDRRYMLHSYPISNFFFETAYEENGNTIY-VAYDFLADASFDPDSHDIFKVTP---- 483
            .|:|    |:...:...|.:|    |.::.:|...:| .:...:||....|.|.|.:.:||
Mouse   499 FPDFILEPKELDDVYDGYEVS----EDSFFQNMLNLYNFSAKVMADQLRKPPSRDQWSMTPQTVN 559

  Fly   484 ----------------------------------LGIRFGLEMLKSFDLFNCKHHKVNMLQLFDD 514
                                              :|:..|.|:..:||....::.|...|:.:..
Mouse   560 AYYLPTKNEIVFPAGILQAPFYAHNHPKALNFGGIGVVMGHELTHAFDDQGREYDKEGNLRPWWQ 624

  Fly   515 NQITTAGDECVSAWTQDNLLSQRDQYLV-------------------VLHLVHEAYFAEGSKFSQ 560
            |:..||.....:...:     |..||.|                   .|...:.||.|...|..:
Mouse   625 NESLTAFQNHTACMEE-----QYSQYQVNGERLNGLQTLGENIADNGGLKAAYNAYKAWLRKHGE 684

  Fly   561 RQP-NFTTMSLRELFFFRFGQ--------SSFGQTLYFGSDFVEGGSP-----INSLTRLPVFVR 611
            .|| ....::..:|||..|.|        .|..:.|     ..:..||     :.:|:....|:|
Mouse   685 EQPLPAVGLTNHQLFFVGFAQVWCSVRTPESSHEGL-----VTDPHSPARFRVLGTLSNSRDFLR 744

  Fly   612 TFNC-----LAPGE 620
            .|.|     :.||:
Mouse   745 HFGCPVGSPMNPGQ 758

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl3	NP_608904.1	GluZincin	42..581	CDD:301352	131/692 (19%)
Ece2	NP_647454.2	M13	112..761	CDD:189000	142/743 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167841078
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840