DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nepl3 and kel

DIOPT Version :9

Sequence 1:	NP_608904.1	Gene:	Nepl3 / 326172	FlyBaseID:	FBgn0031678	Length:	629	Species:	Drosophila melanogaster
Sequence 2:	XP_005157998.1	Gene:	kel / 101882278	ZFINID:	ZDB-GENE-110411-118	Length:	759	Species:	Danio rerio

Alignment Length:	491	Identity:	86/491 - (17%)
Similarity:	168/491 - (34%)	Gaps:	145/491 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 NPNLEIMKRMLDDMDEKVEPCHNFYNSSQKNLKWHAFATVSDQFQLLFDGIE------NEVFEKH 83
            |.:.|:..|.|.:|....:.    ::.|...||     |..|:...|...|:      :|.....
Zfish   127 NKHSEVRTRGLIEMRRGTDG----WSKSDGQLK-----TFPDRQTALLTAIKEILEAPDEAVSMG 182

  Fly    84 SFEEKLQRLYKICSTMERPSLLRYFELVKPGEDLNWPFLT--------PRGGKWPKEKFQWMEAL 140
            :.|:|.:..:|.|...|...        |.|.:   ||||        ...|.|.:..|....||
Zfish   183 AAEQKAKNFFKSCMNAESRE--------KMGSE---PFLTLLQQLGGWAVSGVWNQTDFNSTLAL 236

  Fly   141 --ARLRRYGFNDIMFGMSIRQDPNSDSGQPIVVFE-------------KKYDSLFRFI------- 183
              .:...:.|.::..|....::.::.:...|.:.|             :|..:..|::
Zfish   237 LMGQYSTFPFFNVYVGPEPSEEQSASNRHYIQIDEPHFQFPIEWNSKTQKAKANTRYLRPFYSAC 301

  Fly   184 ------------ESLQNIG---------------LPPKLAKEIAPLDNAIQEMYKSDMKFEHYAR 221
                        .:.|:.|               ||.:|::::......|||:           :
Zfish   302 GQYLVLLGVPSDRTTQHCGLFVSLSTTLAVATFPLPYRLSQKLLYRRTTIQEL-----------Q 355

  Fly   222 DAAP-VKRISLGQLEIYGVSLTKY-LEIVFGRPFSPDFVVHVENLYYLRGLQN------------ 272
            ..|| |..::..|.....:.::|. :.:|...|    :::|:....:|..:|:
Zfish   356 TLAPAVDWLACLQATFQPLLISKSDIVLVHNLP----YIIHMSKTIHLWQVQHELMGTGPLNTYM 416

  Fly   273 ----LMTAVPSQVVANYLTARFSFYIMFTF---------MKHGDSCVTTMRQSMEFASNLLFEER 324
                |.|.:|:      |.:|| |.||..:         |.|...||    |..|...:.|....
Zfish   417 IFSLLQTLIPA------LDSRF-FQIMRNYSIATGDTQEMPHWWRCV----QQTERGFDTLLSHA 470

  Fly   325 ILGRKKLRSYQNQAGKIFDAIRQQLNIRLERNVLKLPPAEISLLQKKLNGLSLSIGNLPGKAGHR 389
            |..:...:..:.....::.:::::|.....|:     ..|...:..|:|.|:..|........:.
Zfish   471 IREKHAQKEAEELIQDVYSSLKKKLTDLSWRD-----EKESDFILNKINSLNPRISTNTNNLSYT 530

  Fly   390 RFVTRYYKELEFADDEELATAHLKV--LEHRTRAEL 423
            .....|.|.:  .::|:..:.:|::  ||.::||.|
Zfish   531 ELNHLYEKVI--LNEEDFFSNYLQILLLEQKSRARL 564

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl3	NP_608904.1	GluZincin	42..581	CDD:301352	81/474 (17%)
kel	XP_005157998.1	GluZincin	99..>620	CDD:301352	86/491 (18%)
kel	XP_005157998.1	GluZincin	583..>721	CDD:301352
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170585555
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.930