DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment eIF2alpha and eif2s1

DIOPT Version :9

Sequence 1:	NP_001285329.1	Gene:	eIF2alpha / 32617	FlyBaseID:	FBgn0261609	Length:	341	Species:	Drosophila melanogaster
Sequence 2:	NP_001005630.1	Gene:	eif2s1 / 448087	XenbaseID:	XB-GENE-989630	Length:	315	Species:	Xenopus tropicalis

Alignment Length:	306	Identity:	190/306 - (62%)
Similarity:	235/306 - (76%)	Gaps:	1/306 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 ALTSRFYNERYPEIEDVVMVNVLSIAEMGAYVHLLEYNNIEGMILLSELSRRRIRSINKLIRVGK 66
            ||:.|||..::||::|||||||.|||||||||.|||||||||||||||||||||||||||||:|:
Frog     3 ALSCRFYQHKFPEVDDVVMVNVRSIAEMGAYVSLLEYNNIEGMILLSELSRRRIRSINKLIRIGR 67

  Fly    67 TEPVVVIRVDKEKGYIDLSKRRVSPEDVEKCTERFAKAKAINSLLRHVADILGFEGNEKLEDLYQ 131
            .|.||||||||:||||||||||||||:..||.::|.|:|.:.|:|||||::|.:..:|:||.|||
Frog    68 NECVVVIRVDKDKGYIDLSKRRVSPEEALKCEDKFTKSKTVYSILRHVAEVLEYTKDEQLESLYQ 132

  Fly   132 KTAWHFEKKYNNKTV-AYDIFKQSVTDPTVFDECNLEPETKEVLLSNIKRKLVSPTVKIRADIEC 195
            :|||.|::||..... |||.||.:|:||.|.|..:|..:.:.||:.||.|:|....||||||||.
Frog   133 RTAWVFDEKYKKPGYGAYDAFKHAVSDPDVLDGLDLNEDERRVLIDNINRRLTPQAVKIRADIEV 197

  Fly   196 SCYGYEGIDAVKASLTKGLELSTEELPIRINLIAPPLYVMTTSTTKKTDGLKALEVAIEHIRAKT 260
            :|||||||||||.:|..||..|||.:||:|||||||.|||||:|.::|:||..|..|:..|:.:.
Frog   198 ACYGYEGIDAVKDALRAGLSCSTENMPIKINLIAPPRYVMTTTTLERTEGLSVLNQAMSVIKERI 262

  Fly   261 SEYDGEFKVIMAPKLVTAIDEADLARRLERAEAENAQVAGDDDEED 306
            .|..|.|.|.|.||:||..||.:|||:|||.|.|||:|.||||.|:
Frog   263 EEKRGVFNVQMEPKVVTDTDETELARQLERLEKENAEVDGDDDAEE 308

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eIF2alpha	NP_001285329.1	SUI2	6..278	CDD:224018	169/272 (62%)
		S1_IF2_alpha	13..88	CDD:239899	65/74 (88%)
		EIF_2_alpha	130..239	CDD:284872	64/109 (59%)
eif2s1	NP_001005630.1	PTZ00248	4..315	CDD:240329	189/305 (62%)
eif2s1	NP_001005630.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	292..315		11/17 (65%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	133	1.000	Domainoid score	I5021
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3020
Inparanoid	1	1.050	374	1.000	Inparanoid score	I2059
OMA	1	1.010	-	-		QHG62227
OrthoDB	1	1.010	-	-		D1093186at2759
OrthoFinder	1	1.000	-	-		FOG0003112
OrthoInspector	1	1.000	-	-		otm48573
Panther	1	1.100	-	-	LDO	PTHR10602
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R591
SonicParanoid	1	1.000	-	-		X1812
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	12.110