DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment eIF2alpha and eif2s1a

DIOPT Version :9

Sequence 1:	NP_001285329.1	Gene:	eIF2alpha / 32617	FlyBaseID:	FBgn0261609	Length:	341	Species:	Drosophila melanogaster
Sequence 2:	NP_955863.1	Gene:	eif2s1a / 321807	ZFINID:	ZDB-GENE-030131-526	Length:	315	Species:	Danio rerio

Alignment Length:	306	Identity:	195/306 - (63%)
Similarity:	237/306 - (77%)	Gaps:	1/306 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 ALTSRFYNERYPEIEDVVMVNVLSIAEMGAYVHLLEYNNIEGMILLSELSRRRIRSINKLIRVGK 66
            ||:||||..|:||:||||||||.|||||||||.|||||||||||||||||||||||||||||:|:
Zfish     3 ALSSRFYQHRFPEVEDVVMVNVRSIAEMGAYVSLLEYNNIEGMILLSELSRRRIRSINKLIRIGR 67

  Fly    67 TEPVVVIRVDKEKGYIDLSKRRVSPEDVEKCTERFAKAKAINSLLRHVADILGFEGNEKLEDLYQ 131
            .|.|||||||||||||||||||||||:..||.::|.|:|.:.|:|||||::|.:..:|:||.|||
Zfish    68 NECVVVIRVDKEKGYIDLSKRRVSPEEAIKCEDKFTKSKTVYSILRHVAEVLEYTKDEQLESLYQ 132

  Fly   132 KTAWHFEKKYNNKTV-AYDIFKQSVTDPTVFDECNLEPETKEVLLSNIKRKLVSPTVKIRADIEC 195
            :|||.|::||..... |||:|||:|:||.:.|...|..|.:.||:.||.|:|....||||||||.
Zfish   133 RTAWVFDEKYKRPGYGAYDVFKQAVSDPAILDCLELTEEERAVLIDNINRRLTPQAVKIRADIEV 197

  Fly   196 SCYGYEGIDAVKASLTKGLELSTEELPIRINLIAPPLYVMTTSTTKKTDGLKALEVAIEHIRAKT 260
            :|||||||||||.:|..||..|||.:||:|||||||.|||||:|.::|:||..|..|:..|:.|.
Zfish   198 ACYGYEGIDAVKEALRAGLTCSTECMPIKINLIAPPRYVMTTTTLERTEGLSVLNQAMAVIKEKI 262

  Fly   261 SEYDGEFKVIMAPKLVTAIDEADLARRLERAEAENAQVAGDDDEED 306
            .|..|.|.:.|.||:||..||.:|||:|||.|.|||:|.||||.|:
Zfish   263 EEKRGVFNIQMEPKVVTDTDETELARQLERLERENAEVDGDDDAEE 308

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eIF2alpha	NP_001285329.1	SUI2	6..278	CDD:224018	173/272 (64%)
		S1_IF2_alpha	13..88	CDD:239899	67/74 (91%)
		EIF_2_alpha	130..239	CDD:284872	65/109 (60%)
eif2s1a	NP_955863.1	PTZ00248	4..315	CDD:240329	194/305 (64%)
		S1_IF2_alpha	14..89	CDD:239899	67/74 (91%)
		EIF_2_alpha	131..241	CDD:284872	65/109 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170592144
Domainoid	1	1.000	134	1.000	Domainoid score	I4974
eggNOG	1	0.900	-	-		E1_COG1093
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3020
Inparanoid	1	1.050	381	1.000	Inparanoid score	I2018
OMA	1	1.010	-	-		QHG62227
OrthoDB	1	1.010	-	-		D1093186at2759
OrthoFinder	1	1.000	-	-		FOG0003112
OrthoInspector	1	1.000	-	-		otm24788
orthoMCL	1	0.900	-	-		OOG6_101220
Panther	1	1.100	-	-	O	PTHR10602
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R591
SonicParanoid	1	1.000	-	-		X1812
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800