DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment eIF2alpha and tif211

DIOPT Version :9

Sequence 1:	NP_001285329.1	Gene:	eIF2alpha / 32617	FlyBaseID:	FBgn0261609	Length:	341	Species:	Drosophila melanogaster
Sequence 2:	NP_594081.1	Gene:	tif211 / 2543455	PomBaseID:	SPAC3G9.09c	Length:	306	Species:	Schizosaccharomyces pombe

Alignment Length:	319	Identity:	166/319 - (52%)
Similarity:	223/319 - (69%)	Gaps:	18/319 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MALTS-RFYNERYPEIEDVVMVNVLSIAEMGAYVHLLEYNNIEGMILLSELSRRRIRSINKLIRV 64
            |:.|| |.|..|:||::::|:|||..|.||||||.||||:|||||:||||||||||||:.|.|||
pombe     1 MSTTSCRMYENRFPEVDELVVVNVRQIQEMGAYVKLLEYDNIEGMVLLSELSRRRIRSVQKHIRV 65

  Fly    65 GKTEPVVVIRVDKEKGYIDLSKRRVSPEDVEKCTERFAKAKAINSLLRHVADILGFEGNEKLEDL 129
            |:.|.|||:|||||||||||||||||||||.||.|||.|:||::|::||:|:    :.|..||.:
pombe    66 GRNEVVVVLRVDKEKGYIDLSKRRVSPEDVVKCEERFNKSKAVHSIMRHIAE----KHNVPLETM 126

  Fly   130 YQKTAWHFEKKYNNKTVAYDIFKQSVTDPT-VFDECNLEPETKEV---LLSNIKRKLVSPTVKIR 190
            |....|...:||.:   |||.||.::::|. ||:  .|||....|   ||:.|.|:|....:|||
pombe   127 YTTIGWPLYRKYGH---AYDAFKLAISNPDHVFE--GLEPPKSGVINDLLAQISRRLTPQPIKIR 186

  Fly   191 ADIECSCYGYEGIDAVKASLTKGLELSTEELPIRINLIAPPLYVMTTSTTKKTDGLKALEVAIEH 255
            ||:|.:|:|||||:|:||:|....::.|||:||::.|:||||||:.|:...|:.|||.||.||..
pombe   187 ADVEVTCFGYEGINAIKAALKAAEDVHTEEVPIKVKLVAPPLYVLLTNALDKSLGLKKLEEAIGA 251

  Fly   256 IRAKTSEYDGEFKVIMAPKLVTAIDEADLARRLERAEAENAQVAGDDDEEDGADQEGMQ 314
            |....:..:|...|.|.||.|:..||.:||..:::.|.|||:::|  ||||  ||.|.:
pombe   252 IEKSITASNGTCTVKMKPKAVSETDELELADLMKKFEKENAEISG--DEED--DQSGSE 306

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eIF2alpha	NP_001285329.1	SUI2	6..278	CDD:224018	147/275 (53%)
		S1_IF2_alpha	13..88	CDD:239899	56/74 (76%)
		EIF_2_alpha	130..239	CDD:284872	50/112 (45%)
tif211	NP_594081.1	PTZ00248	5..306	CDD:240329	164/313 (52%)
		S1_IF2_alpha	14..89	CDD:239899	56/74 (76%)
		EIF_2_alpha	127..235	CDD:284872	50/112 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	114	1.000	Domainoid score	I1536
eggNOG	1	0.900	-	-		E1_COG1093
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3020
Inparanoid	1	1.050	297	1.000	Inparanoid score	I616
OMA	1	1.010	-	-		QHG62227
OrthoFinder	1	1.000	-	-		FOG0003112
OrthoInspector	1	1.000	-	-		oto101285
orthoMCL	1	0.900	-	-		OOG6_101220
Panther	1	1.100	-	-	LDO	PTHR10602
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R591
SonicParanoid	1	1.000	-	-		X1812
TreeFam	1	0.960	-	-
	14	13.860