DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment eIF2alpha and EIF2S1

DIOPT Version :9

Sequence 1:	NP_001285329.1	Gene:	eIF2alpha / 32617	FlyBaseID:	FBgn0261609	Length:	341	Species:	Drosophila melanogaster
Sequence 2:	NP_004085.1	Gene:	EIF2S1 / 1965	HGNCID:	3265	Length:	315	Species:	Homo sapiens

Alignment Length:	305	Identity:	190/305 - (62%)
Similarity:	236/305 - (77%)	Gaps:	1/305 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LTSRFYNERYPEIEDVVMVNVLSIAEMGAYVHLLEYNNIEGMILLSELSRRRIRSINKLIRVGKT 67
            |:.|||..::||:||||||||.|||||||||.|||||||||||||||||||||||||||||:|:.
Human     4 LSCRFYQHKFPEVEDVVMVNVRSIAEMGAYVSLLEYNNIEGMILLSELSRRRIRSINKLIRIGRN 68

  Fly    68 EPVVVIRVDKEKGYIDLSKRRVSPEDVEKCTERFAKAKAINSLLRHVADILGFEGNEKLEDLYQK 132
            |.|||||||||||||||||||||||:..||.::|.|:|.:.|:|||||::|.:..:|:||.|:|:
Human    69 ECVVVIRVDKEKGYIDLSKRRVSPEEAIKCEDKFTKSKTVYSILRHVAEVLEYTKDEQLESLFQR 133

  Fly   133 TAWHFEKKYNNKTV-AYDIFKQSVTDPTVFDECNLEPETKEVLLSNIKRKLVSPTVKIRADIECS 196
            |||.|:.||..... |||.||.:|:||::.|..:|..:.:|||::||.|:|....||||||||.:
Human   134 TAWVFDDKYKRPGYGAYDAFKHAVSDPSILDSLDLNEDEREVLINNINRRLTPQAVKIRADIEVA 198

  Fly   197 CYGYEGIDAVKASLTKGLELSTEELPIRINLIAPPLYVMTTSTTKKTDGLKALEVAIEHIRAKTS 261
            |||||||||||.:|..||..|||.:||:|||||||.|||||:|.::|:||..|..|:..|:.|..
Human   199 CYGYEGIDAVKEALRAGLNCSTENMPIKINLIAPPRYVMTTTTLERTEGLSVLSQAMAVIKEKIE 263

  Fly   262 EYDGEFKVIMAPKLVTAIDEADLARRLERAEAENAQVAGDDDEED 306
            |..|.|.|.|.||:||..||.:|||::||.|.|||:|.||||.|:
Human   264 EKRGVFNVQMEPKVVTDTDETELARQMERLERENAEVDGDDDAEE 308

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eIF2alpha	NP_001285329.1	SUI2	6..278	CDD:224018	171/272 (63%)
		S1_IF2_alpha	13..88	CDD:239899	67/74 (91%)
		EIF_2_alpha	130..239	CDD:284872	63/109 (58%)
EIF2S1	NP_004085.1	PTZ00248	4..315	CDD:240329	190/305 (62%)
EIF2S1	NP_004085.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	293..315		10/16 (63%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165156521
Domainoid	1	1.000	133	1.000	Domainoid score	I5096
eggNOG	1	0.900	-	-		E1_COG1093
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3020
Inparanoid	1	1.050	376	1.000	Inparanoid score	I2104
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG62227
OrthoDB	1	1.010	-	-		D1093186at2759
OrthoFinder	1	1.000	-	-		FOG0003112
OrthoInspector	1	1.000	-	-		oto90050
orthoMCL	1	0.900	-	-		OOG6_101220
Panther	1	1.100	-	-	LDO	PTHR10602
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1812
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.770