DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment eIF2alpha and eif-2alpha

DIOPT Version :9

Sequence 1:	NP_001285329.1	Gene:	eIF2alpha / 32617	FlyBaseID:	FBgn0261609	Length:	341	Species:	Drosophila melanogaster
Sequence 2:	NP_001368001.1	Gene:	eif-2alpha / 171769	WormBaseID:	WBGene00021351	Length:	342	Species:	Caenorhabditis elegans

Alignment Length:	344	Identity:	170/344 - (49%)
Similarity:	238/344 - (69%)	Gaps:	13/344 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 RFYNERYPEIEDVVMVNVLSIAEMGAYVHLLEYNNIEGMILLSELSRRRIRSINKLIRVGKTEPV 70
            |||..::|::|:.|:.||..||:|||||.|.|||:.||||||||||||||||:|||||||::|.|
Worm     4 RFYENQFPDVEETVVANVKMIADMGAYVRLSEYNDKEGMILLSELSRRRIRSVNKLIRVGRSESV 68

  Fly    71 VVIRVDKEKGYIDLSKRRVSPEDVEKCTERFAKAKAINSLLRHVADILGFEGNEKLEDLYQKTAW 135
            |||||||:|||||||||||..:|:::|.||||.||.:||:|||||:.:|:..:|:||||||||||
Worm    69 VVIRVDKDKGYIDLSKRRVYQKDLKQCDERFANAKMVNSILRHVAEQVGYTTDEELEDLYQKTAW 133

  Fly   136 HFEKKYNNKTVAYDIFKQSVTDPTVFDECNLEPETKEVLLSNIKRKLVSPTVKIRADIECSCYGY 200
            ||::|...|..:||.||:::|:||:.|||::..:.||.||.:|::||....||||||||.||:.|
Worm   134 HFDRKEKRKAASYDAFKKAITEPTILDECDISADIKEKLLEDIRKKLTPQAVKIRADIEVSCFDY 198

  Fly   201 EGIDAVKASLTKGLELSTEELPIRINLIAPPLYVMTTSTTKKTDGLKALEVAIEHIRAKTSEYDG 265
            :|||||||:|..|...|....||:|||||.|.:|:||.|..:..|::|:...::.|:.....:.|
Worm   199 DGIDAVKAALIAGKNCSNGTFPIKINLIAAPHFVVTTQTLDREGGIEAVNSILDTIKNAIEGFKG 263

  Fly   266 EFKVIMAPKLVTAIDEADLARRLERAEAENAQVAGDDDEEDGADQEGM--------QFDPEKEFN 322
            :|.:....::||.||:.......:..|.|:.:   |:|||:..|.:|:        |.|.|:...
Worm   264 KFTIKEEARIVTDIDDEKKKGDGDEDEEESEE---DEDEEEDEDDDGLMAPKGLDQQVDAEEASR 325

  Fly   323 HKGSGAGRANEEDEEEEED 341
            .....||  ::||.:||:|
Worm   326 DNRKKAG--DDEDSDEEDD 342

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eIF2alpha	NP_001285329.1	SUI2	6..278	CDD:224018	149/271 (55%)
		S1_IF2_alpha	13..88	CDD:239899	56/74 (76%)
		EIF_2_alpha	130..239	CDD:284872	59/108 (55%)
eif-2alpha	NP_001368001.1	PTZ00248	3..276	CDD:240329	149/271 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160164551
Domainoid	1	1.000	133	1.000	Domainoid score	I3167
eggNOG	1	0.900	-	-		E1_COG1093
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3020
Inparanoid	1	1.050	332	1.000	Inparanoid score	I1430
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG62227
OrthoDB	1	1.010	-	-		D1093186at2759
OrthoFinder	1	1.000	-	-		FOG0003112
OrthoInspector	1	1.000	-	-		oto18922
orthoMCL	1	0.900	-	-		OOG6_101220
Panther	1	1.100	-	-	LDO	PTHR10602
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R591
SonicParanoid	1	1.000	-	-		X1812
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	16	15.840