Protein Alignment Mulk and SPHK1

DIOPT Version :10

• Sequence 1: NP_723549.1
• Gene: Mulk / 326168
• FlyBaseID: FBgn0260750
• Length: 408
• Species: Drosophila melanogaster
• Sequence 2: NP_892010.2
• Gene: SPHK1 / 8877
• HGNCID: 11240
• Length: 470
• Species: Homo sapiens
• Alignment Length: 386
• Identity: 98/386 - (25%)
• Similarity: 157/386 - (40%)
• Gaps: 77/386 - (19%)

  Fly    53 RPKKVLVVMNPVANKKRSEKFFKNYCEPVLHLAGYSVEILRTNHIGHAKTYV--EELATLPDAIV 115
            ||.:|||::||...|.::.:.|:::.:|:|..|..|..::.|....||:..|  |||... ||:|
Human    99 RPCRVLVLLNPRGGKGKALQLFRSHVQPLLAEAEISFTLMLTERRNHARELVRSEELGRW-DALV 162

  Fly   116 VAGGDGTSSEVVTGLMRR----RGNLCPITILPLGRSVQSASKRINIFGVKDVDYVKSLS----- 171
            |..|||...|||.|||.|    .....|:..||.|.....|:...:..|.:.|.....|:
Human   163 VMSGDGLMHEVVNGLMERPDWETAIQKPLCSLPAGSGNALAASLNHYAGYEQVTNEDLLTNCTLL 227

  Fly   172 ---KALEPMLKDESQYQSVIRFDVINEEDGSNSQLKPIFGLNGLSWGLLEDIDAAKDKYWYFGPL 233
               :.|.||             ::::....|..:|   |.:..|:||.:.|:|...:||...|.:
Human   228 LCRRLLSPM-------------NLLSLHTASGLRL---FSVLSLAWGFIADVDLESEKYRRLGEM 276

  Fly   234 RHYAS-----AASKSFADNWS-LKTDYV--YTPPCP-----GCVDCAATVQRQE------TAQPS 279
            |....     ||.:::....: |....|  .||..|     |.|| |..|..:|      |..|.
Human   277 RFTLGTFLRLAALRTYRGRLAYLPVGRVGSKTPASPVVVQQGPVD-AHLVPLEEPVPSHWTVVPD 340

  Fly   280 GLFTRGLIKYKNNPGETKRPLVKNDNCSKKFE---GSAEASQININCVQNKDNFAELESQFISSL 341
            ..|...|....::.|            |:.|.   |...|..:::..|:...:.|.|...|: ::
Human   341 EDFVLVLALLHSHLG------------SEMFAAPMGRCAAGVMHLFYVRAGVSRAMLLRLFL-AM 392

  Fly   342 QPGWEFIKQIPEVTCSKILPSLVVKSRTIQLHPDGEMGEKFYSIDGEEYDARPIKVSVVPN 402
            :.|...     |..|..::...||..|   |.|  :.|:..:::|||...:..::..|.||
Human   393 EKGRHM-----EYECPYLVYVPVVAFR---LEP--KDGKGVFAVDGELMVSEAVQGQVHPN 443

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mulk	NP_723549.1	LCB5	53..>245	CDD:441205	59/210 (28%)
		DAGK_cat	56..>146	CDD:425868	35/95 (37%)
		AGK_C	209..408	CDD:466156	50/216 (23%)
SPHK1	NP_892010.2	PLN02958	<97..431	CDD:215517	95/372 (26%)