DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mulk and Agk

DIOPT Version :9

Sequence 1:	NP_723549.1	Gene:	Mulk / 326168	FlyBaseID:	FBgn0260750	Length:	408	Species:	Drosophila melanogaster
Sequence 2:	NP_076027.1	Gene:	Agk / 69923	MGIID:	1917173	Length:	421	Species:	Mus musculus

Alignment Length:	444	Identity:	118/444 - (26%)
Similarity:	199/444 - (44%)	Gaps:	78/444 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 YLRVIRNNWKKCTFGAAVSVYALQALKTHIEIEQH----MREFA---SNIQANWI---SDRPKKV 57
            :.:.:||:|||.|.|..:..:.     .|....:|    :|..|   :.:..|.:   :.:.||.
Mouse     4 FFKTLRNHWKKTTAGLCLLTWG-----GHWLYGKHCDNLLRRAACQEAQVFGNQLIPPNAQVKKA 63

  Fly    58 LVVMNPVANKKRSEKFFKNYCEPVLHLAGYSVEILRTNHIGHAKTYVEELATLPDAIVVAGGDGT 122
            .|.:||.|.|.::...|:....|:|||:|..|.:::|::.|.||..: ||....|.|:|||||||
Mouse    64 TVFLNPAACKGKARTLFEKNAAPILHLSGMDVTVVKTDYEGQAKKLL-ELMESTDVIIVAGGDGT 127

  Fly   123 SSEVVTGLMRRRG----NLCPITILPLGRSVQSASKRINIFGVKDVDYVKSLSKALEPMLKDESQ 183
            ..|||||::||..    :..||..:|||   |::|....:| .:..:.|:.::.|...::|.|:
Mouse   128 LQEVVTGVLRRTDEATFSKIPIGFIPLG---QTSSLSHTLF-AESGNKVQHITDATLAIVKGET- 187

  Fly   184 YQSVIRFDVINEEDGSNSQLKPIFGLNGLSWGLLEDIDAAKDKYWYFGPLR----HYASAASKSF 244
                :..||: :..|...|  |::.:.||.||...|......||||.|||:    |:.|...:
Mouse   188 ----VPLDVL-QIKGEKEQ--PVYAMTGLRWGSFRDAGVKVSKYWYLGPLKTKAAHFFSTLQE-- 243

  Fly   245 ADNW--SLKTDYVYT-----PPCPGCVDCAATVQRQETAQPSGLF---TRGLIKYKNNPGETK-- 297
               |  :.:....||     ||          ::.:||.....|:   .|.|..:...|.:..
Mouse   244 ---WPQTHQASISYTGPRERPP----------IEPEETPPRPSLYRRILRRLASFWAQPQDASSR 295

  Fly   298 --RPLVKNDNCSKKFEGSAEASQININCVQNKDNFAE--LESQFISSLQPGWEFI----KQIPEV 354
              .|.|..|......|.|.......:: :.:|::|..  :|...:|.    .:||    |::.:.
Mouse   296 EVSPEVWKDVQLSTIELSITTRNTQLD-LMSKEDFMNICIEPDTVSK----GDFIIIGSKKVRDP 355

  Fly   355 TCSKILPSLVVKSRTIQLHPDGEMGEKFYSIDGEEYDARPIKVSVVPNAIKVFC 408
            .........:..|....:.|:|..|.  :|||.|||:|.|::|.::|..::.||
Mouse   356 GLRAAGTECLQASHCTLVLPEGTEGS--FSIDSEEYEAMPVEVKLLPRKLRFFC 407

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mulk	NP_723549.1	LCB5	55..407	CDD:224513	104/379 (27%)
Mulk	NP_723549.1	DAGK_cat	56..>146	CDD:279163	38/93 (41%)
Agk	NP_076027.1	Hydrophobic. /evidence=ECO:0000250\|UniProtKB:Q53H12	15..31		3/20 (15%)
		DAGK_cat	62..195	CDD:279163	49/143 (34%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	252..271		6/28 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167849621
Domainoid	1	1.000	74	1.000	Domainoid score	I9177
eggNOG	1	0.900	-	-		E1_COG1597
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H41239
Inparanoid	1	1.050	120	1.000	Inparanoid score	I4770
Isobase	1	0.950	-	0	Normalized mean entropy	S4975
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006608
OrthoInspector	1	1.000	-	-		oto94343
orthoMCL	1	0.900	-	-		OOG6_108319
Panther	1	1.100	-	-	LDO	PTHR12358
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2949
SonicParanoid	1	1.000	-	-		X6357
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.730