DRSC/TRiP Functional Genomics Resources

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Protein Alignment Mulk and CERK

DIOPT Version :9

Sequence 1:NP_723549.1 Gene:Mulk / 326168 FlyBaseID:FBgn0260750 Length:408 Species:Drosophila melanogaster
Sequence 2:NP_073603.2 Gene:CERK / 64781 HGNCID:19256 Length:537 Species:Homo sapiens


Alignment Length:308 Identity:77/308 - (25%)
Similarity:124/308 - (40%) Gaps:58/308 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly     5 RVIRNNWKKCTFGAAVSVYALQALKTHIEIEQHMREFASNIQANWISDRPKKVLVVMNPVANKKR 69
            |..|:.||    .|.|:.:..:....|:.: |.:||....     ::.|||.:||.:||...|.:
Human    91 RARRHRWK----WAQVTFWCPEEQLCHLWL-QTLREMLEK-----LTSRPKHLLVFINPFGGKGQ 145

  Fly    70 SEKFFKNYCEPVLHLAGYSVEILRTNHIGHAKTYVEEL-ATLPDAIVVAGGDGTSSEVVTGLMRR 133
            .::.::....|:..||..:.:|:.|.|...||..:.|: ....|.||..||||..|||:.||:.|
Human   146 GKRIYERKVAPLFTLASITTDIIVTEHANQAKETLYEINIDKYDGIVCVGGDGMFSEVLHGLIGR 210

  Fly   134 ------------RGNLCP----ITILPLGRSVQSASKRINIFGVKDVDYVKSLSKALEPMLKDES 182
                        |..|.|    |.|:|.|.:.......:   |..|.:     :.||..::.|. 
Human   211 TQRSAGVDQNHPRAVLVPSSLRIGIIPAGSTDCVCYSTV---GTSDAE-----TSALHIVVGDS- 266

  Fly   183 QYQSVIRFDVINEEDGSNSQLKPIFGLNGLSWGLLEDIDAAKDKYWYFGPLRHYASAASKSFADN 247
                 :..||.:..  .||.|.. :.::.|.:|...||....:|..:.| |..|..:..|:|..:
Human   267 -----LAMDVSSVH--HNSTLLR-YSVSLLGYGFYGDIIKDSEKKRWLG-LARYDFSGLKTFLSH 322

  Fly   248 WSLKTDYVYTP------------PC-PGCVDCAATVQRQETAQPSGLF 282
            ...:....:.|            || .||..|..:.|:.|..|...|:
Human   323 HCYEGTVSFLPAQHTVGSPRDRKPCRAGCFVCRQSKQQLEEEQKKALY 370

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MulkNP_723549.1 LCB5 55..407 CDD:224513 65/258 (25%)
DAGK_cat 56..>146 CDD:279163 33/106 (31%)
CERKNP_073603.2 Required for binding to sulfatide and phosphoinositides. /evidence=ECO:0000269|PubMed:19168031 1..125 10/38 (26%)
Essential for enzyme activity. /evidence=ECO:0000269|PubMed:16269826 1..115 7/27 (26%)
PLN02204 55..528 CDD:215126 77/308 (25%)
Substrate binding. /evidence=ECO:0000250|UniProtKB:Q9NYA1 195..198 2/2 (100%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG1597
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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