DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mulk and Sphk2

DIOPT Version :9

Sequence 1:	NP_723549.1	Gene:	Mulk / 326168	FlyBaseID:	FBgn0260750	Length:	408	Species:	Drosophila melanogaster
Sequence 2:	NP_001166032.1	Gene:	Sphk2 / 56632	MGIID:	1861380	Length:	617	Species:	Mus musculus

Alignment Length:	231	Identity:	55/231 - (23%)
Similarity:	96/231 - (41%)	Gaps:	39/231 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    53 RPKKVLVVMNPVANKKRSEKFFKNYCEPVLHLAGYSVEILRTNHIGHAKTYVEELATLP-DAIVV 116
            |..::|:::||...:..:.:...::..|::..||.|..:::|....||:..|:.|:... :.||.
Mouse   144 RKPRLLILVNPFGGRGLAWQRCMDHVVPMISEAGLSFNLIQTERQNHARELVQGLSLSEWEGIVT 208

  Fly   117 AGGDGTSSEVVTGLMRR----RGNLCPITILPLGRSVQSASKRINIFG----VKDVDYVKSLSKA 173
            ..|||...||:.||:.|    .....||.:||.| |..:.:..:|..|    |..||.:.:.|..
Mouse   209 VSGDGLLYEVLNGLLDRPDWEDAVRMPIGVLPCG-SGNALAGAVNHHGGFEQVVGVDLLLNCSLL 272

  Fly   174 L-----EPMLKDESQYQSVIRFDVINEEDGSNSQLKPIFGLNGLSWGLLEDIDAAKDKYWYFGPL 233
            |     .|:             |:::....|.|:   .|....::||.|.|:|...:::...|..
Mouse   273 LCRGGSHPL-------------DLLSVTLASGSR---CFSFLSVAWGFLSDVDIHSERFRALGSA 321

  Fly   234 RHYASAASKSFADNWSLKTDYVYTP-------PCPG 262
            | :...|....|...:.:....|.|       |.||
Mouse   322 R-FTLGAVLGLASLHTYRGRLSYLPATTEPALPIPG 356

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mulk	NP_723549.1	LCB5	55..407	CDD:224513	54/229 (24%)
Mulk	NP_723549.1	DAGK_cat	56..>146	CDD:279163	26/94 (28%)
Sphk2	NP_001166032.1	Required for binding to sulfatide and phosphoinositides and for membrane localization. /evidence=ECO:0000250	1..140
		NLS. /evidence=ECO:0000269\|PubMed:12954646	87..95
		PLN02958	<142..608	CDD:215517	55/231 (24%)
		Substrate binding. /evidence=ECO:0000250\|UniProtKB:Q9NYA1	210..213		1/2 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	371..472
		NES. /evidence=ECO:0000250\|UniProtKB:Q9NRA0	381..390
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1597
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810