Protein Alignment Mulk and AGK

DIOPT Version :10

• Sequence 1: NP_723549.1
• Gene: Mulk / 326168
• FlyBaseID: FBgn0260750
• Length: 408
• Species: Drosophila melanogaster
• Sequence 2: NP_060708.1
• Gene: AGK / 55750
• HGNCID: 21869
• Length: 422
• Species: Homo sapiens
• Alignment Length: 459
• Identity: 122/459 - (26%)
• Similarity: 203/459 - (44%)
• Gaps: 107/459 - (23%)

  Fly     3 YLRVIRNNWKKCTFGAAVSVYALQALKTHIEIEQH----MREFA---SNIQANWI---SDRPKKV 57
            :.:.:||:|||.|.|..:..:.     .|....:|    :|..|   :.:..|.:   :.:.||.
Human     4 FFKTLRNHWKKTTAGLCLLTWG-----GHWLYGKHCDNLLRRAACQEAQVFGNQLIPPNAQVKKA 63

  Fly    58 LVVMNPVANKKRSEKFFKNYCEPVLHLAGYSVEILRTNHIGHAKTYVEELATLPDAIVVAGGDGT 122
            .|.:||.|.|.::...|:....|:|||:|..|.|::|::.|.||..: ||....|.|:|||||||
Human    64 TVFLNPAACKGKARTLFEKNAAPILHLSGMDVTIVKTDYEGQAKKLL-ELMENTDVIIVAGGDGT 127

  Fly   123 SSEVVTGLMRRRG----NLCPITILPLGRSVQSASKRINIFGVKDVDYVKSLSKALEPMLKDESQ 183
            ..|||||::||..    :..||..:|||   :::|....:| .:..:.|:.::.|...::|.|:
Human   128 LQEVVTGVLRRTDEATFSKIPIGFIPLG---ETSSLSHTLF-AESGNKVQHITDATLAIVKGET- 187

  Fly   184 YQSVIRFDVINEEDGSNSQLKPIFGLNGLSWGLLEDIDAAKDKYWYFGPLR----HYASAASKSF 244
                :..||: :..|...|  |:|.:.||.||...|......||||.|||:    |:.|...:
Human   188 ----VPLDVL-QIKGEKEQ--PVFAMTGLRWGSFRDAGVKVSKYWYLGPLKIKAAHFFSTLKE-- 243

  Fly   245 ADNW--SLKTDYVYTPPC---PGCVDCAATVQRQET-AQPSGLF---TRGLIKYKNNP----GET 296
               |  :.:....||.|.   |.        :.:|| .|...|:   .|.|..|...|    .:.
Human   244 ---WPQTHQASISYTGPTERPPN--------EPEETPVQRPSLYRRILRRLASYWAQPQDALSQE 297

  Fly   297 KRPLVKND-----------NCSKKFEGSAEASQININCVQ----NKDNFAELESQFISSLQPGWE 346
            ..|.|..|           ..:.:.:.:::...:|| |::    :|.:|..:.|:.:.:
Human   298 VSPEVWKDVQLSTIELSITTRNNQLDPTSKEDFLNI-CIEPDTISKGDFITIGSRKVRN------ 355

  Fly   347 FIKQIPEVTCSKILPSLVVK-------SRTIQLHPDGEMGEKFYSIDGEEYDARPIKVSVVPNAI 404
                          |.|.|:       |:...|.|:|..|.  :|||.|||:|.|::|.::|..:
Human   356 --------------PKLHVEGTECLQASQCTLLIPEGAGGS--FSIDSEEYEAMPVEVKLLPRKL 404

  Fly   405 KVFC 408
            :.||
Human   405 QFFC 408

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mulk	NP_723549.1	LCB5	53..>245	CDD:441205	68/199 (34%)
		DAGK_cat	56..>146	CDD:425868	39/93 (42%)
		AGK_C	209..408	CDD:466156	54/237 (23%)
AGK	NP_060708.1	Hydrophobic. /evidence=ECO:0000305	15..31		3/20 (15%)
		DAGK_cat	62..195	CDD:425868	49/143 (34%)
		AGK_C	206..421	CDD:466156	56/239 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	249..271		6/29 (21%)