DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mulk and AGK

DIOPT Version :9

Sequence 1:	NP_723549.1	Gene:	Mulk / 326168	FlyBaseID:	FBgn0260750	Length:	408	Species:	Drosophila melanogaster
Sequence 2:	NP_060708.1	Gene:	AGK / 55750	HGNCID:	21869	Length:	422	Species:	Homo sapiens

Alignment Length:	459	Identity:	122/459 - (26%)
Similarity:	203/459 - (44%)	Gaps:	107/459 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 YLRVIRNNWKKCTFGAAVSVYALQALKTHIEIEQH----MREFA---SNIQANWI---SDRPKKV 57
            :.:.:||:|||.|.|..:..:.     .|....:|    :|..|   :.:..|.:   :.:.||.
Human     4 FFKTLRNHWKKTTAGLCLLTWG-----GHWLYGKHCDNLLRRAACQEAQVFGNQLIPPNAQVKKA 63

  Fly    58 LVVMNPVANKKRSEKFFKNYCEPVLHLAGYSVEILRTNHIGHAKTYVEELATLPDAIVVAGGDGT 122
            .|.:||.|.|.::...|:....|:|||:|..|.|::|::.|.||..: ||....|.|:|||||||
Human    64 TVFLNPAACKGKARTLFEKNAAPILHLSGMDVTIVKTDYEGQAKKLL-ELMENTDVIIVAGGDGT 127

  Fly   123 SSEVVTGLMRRRG----NLCPITILPLGRSVQSASKRINIFGVKDVDYVKSLSKALEPMLKDESQ 183
            ..|||||::||..    :..||..:|||   :::|....:| .:..:.|:.::.|...::|.|:
Human   128 LQEVVTGVLRRTDEATFSKIPIGFIPLG---ETSSLSHTLF-AESGNKVQHITDATLAIVKGET- 187

  Fly   184 YQSVIRFDVINEEDGSNSQLKPIFGLNGLSWGLLEDIDAAKDKYWYFGPLR----HYASAASKSF 244
                :..||: :..|...|  |:|.:.||.||...|......||||.|||:    |:.|...:
Human   188 ----VPLDVL-QIKGEKEQ--PVFAMTGLRWGSFRDAGVKVSKYWYLGPLKIKAAHFFSTLKE-- 243

  Fly   245 ADNW--SLKTDYVYTPPC---PGCVDCAATVQRQET-AQPSGLF---TRGLIKYKNNP----GET 296
               |  :.:....||.|.   |.        :.:|| .|...|:   .|.|..|...|    .:.
Human   244 ---WPQTHQASISYTGPTERPPN--------EPEETPVQRPSLYRRILRRLASYWAQPQDALSQE 297

  Fly   297 KRPLVKND-----------NCSKKFEGSAEASQININCVQ----NKDNFAELESQFISSLQPGWE 346
            ..|.|..|           ..:.:.:.:::...:|| |::    :|.:|..:.|:.:.:
Human   298 VSPEVWKDVQLSTIELSITTRNNQLDPTSKEDFLNI-CIEPDTISKGDFITIGSRKVRN------ 355

  Fly   347 FIKQIPEVTCSKILPSLVVK-------SRTIQLHPDGEMGEKFYSIDGEEYDARPIKVSVVPNAI 404
                          |.|.|:       |:...|.|:|..|.  :|||.|||:|.|::|.::|..:
Human   356 --------------PKLHVEGTECLQASQCTLLIPEGAGGS--FSIDSEEYEAMPVEVKLLPRKL 404

  Fly   405 KVFC 408
            :.||
Human   405 QFFC 408

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mulk	NP_723549.1	LCB5	55..407	CDD:224513	108/394 (27%)
Mulk	NP_723549.1	DAGK_cat	56..>146	CDD:279163	39/93 (42%)
AGK	NP_060708.1	Hydrophobic. /evidence=ECO:0000305	15..31		3/20 (15%)
		DAGK_cat	62..195	CDD:395631	49/143 (34%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	249..271		6/29 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159253
Domainoid	1	1.000	74	1.000	Domainoid score	I9211
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H41239
Inparanoid	1	1.050	119	1.000	Inparanoid score	I4792
Isobase	1	0.950	-	0	Normalized mean entropy	S4975
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1312024at2759
OrthoFinder	1	1.000	-	-		FOG0006608
OrthoInspector	1	1.000	-	-		oto90759
orthoMCL	1	0.900	-	-		OOG6_108319
Panther	1	1.100	-	-	LDO	PTHR12358
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6357
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	13	12.850