Protein Alignment ZnT33D and SLC30A4

DIOPT Version :9

• Sequence 1: NP_723732.2
• Gene: ZnT33D / 326167
• FlyBaseID: FBgn0051860
• Length: 701
• Species: Drosophila melanogaster
• Sequence 2: NP_037441.2
• Gene: SLC30A4 / 7782
• HGNCID: 11015
• Length: 429
• Species: Homo sapiens
• Alignment Length: 488
• Identity: 146/488 - (29%)
• Similarity: 247/488 - (50%)
• Gaps: 79/488 - (16%)

  Fly   191 WKRPTPVVLKSNQNYSANKNSENALDAKPQTATNTEETHGCINILKVPFQSNLYYVPEKPSRQDK 255
            |||...::.|.:.....|..|  |.|...:..   :|.....|.|:|....:....||:|..
Human     7 WKRLKSMLRKDDAPLFLNDTS--AFDFSDEAG---DEGLSRFNKLRVVVADDGSEAPERPVN--- 63

  Fly   256 GSGTSDFQPGA-PETPIVENSAVDSDRKAVEIMPENVKNSE-EKKIDNSDSTKTVTITGHSHITA 318
                     || |.....::|.:|.|      :|  :.||: ..|:|:.|:..
Human    64 ---------GAHPTLQADDDSLLDQD------LP--LTNSQLSLKVDSCDNCS------------ 99

  Fly   319 KWDGHCHFKERETGVDKAARRVLIIACILCTIFLILEVIGGILSNSLAIATDAAHLLTDLASFLI 383
                    |:||....:..:..|.||.:|..:|:|.|::||.::|||||.|||.|:||||::.::
Human   100 --------KQREILKQRKVKARLTIAAVLYLLFMIGELVGGYIANSLAIMTDALHMLTDLSAIIL 156

  Fly   384 SISALHLAGRPSSERLNYGWHRAEVIGAMVSIFFIWVVTGILVYMAIMRWVNQDFELDAKIMLIT 448
            ::.||.|:.:..::|..:|:||.||:.||:|:..::::.|.|:|.|:.|.::.::|::..|||||
Human   157 TLLALWLSSKSPTKRFTFGFHRLEVLSAMISVLLVYILMGFLLYEAVQRTIHMNYEINGDIMLIT 221

  Fly   449 SALAILFNVIMAMQL-----QHGHSHSLPGVHKMSKDAGSVLGSKMILLLGKSVSMQYAAKGHEN 508
            :|:.:..||||...|     :|.||||||. :..::.:|....                 .|.::
Human   222 AAVGVAVNVIMGFLLNQSGHRHSHSHSLPS-NSPTRGSGCERN-----------------HGQDS 268

  Fly   509 INVRAAIIHVVGDIIQSFGVFVAALIIFFWPEWAFMDSVCTFVFSVLVLVVTFKILRDVLMVLME 573
            :.||||.:|.:||::||.||.:||.||.|.||:...|.:||:|||:||...||:|:.|.:::::|
Human   269 LAVRAAFVHALGDLVQSVGVLIAAYIIRFKPEYKIADPICTYVFSLLVAFTTFRIIWDTVVIILE 333

  Fly   574 ATPDFMDYEEVKQTFLSISGVEHVHNLRIWALSINKVALSAHLAI-----SKDADPQLILEEATT 633
            ..|..::.:.:|:..:.|..|..|.:|.||:|:..|.....|:.:     ||..:.|   .:|..
Human   334 GVPSHLNVDYIKEALMKIEDVYSVEDLNIWSLTSGKSTAIVHIQLIPGSSSKWEEVQ---SKANH 395

  Fly   634 LIHKRFKFFETTIQIEEYSPGME-NCGQCLSPS 665
            |:...|..:..|||::.|...:: .|..|.|.|
Human   396 LLLNTFGMYRCTIQLQSYRQEVDRTCANCQSSS 428

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ZnT33D	NP_723732.2	CDF	350..651	CDD:273544	107/310 (35%)
		Cation_efflux	350..572	CDD:279834	86/226 (38%)
SLC30A4	NP_037441.2	CDF	123..413	CDD:273544	107/310 (35%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	186	1.000	Domainoid score	I3351
eggNOG	1	0.900	-	-		E1_COG1230
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D351752at33208
OrthoFinder	1	1.000	-	-		FOG0000470
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100508
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.720